Is the Immune System a Functional Idiotypic Network?

  • J. Urbain


Although supported by a lot of data it is fair to say that the idiotype network hypothesis is not universally accepted. This is partly due to the fact that many people do not talk about the same things even when they use the same words. Furthermore, different contradictory models have been put forward.


Somatic Mutation Germ Line Immune Network Associative Recognition Germ Line Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Binz, H., Frischknecht, H., Wigzell, H.,1979, Some studies on idiotypes and antiidiotypic reactions and receptors in antiallo-MHC T cells immunity, Ann. Immunol. (Inst.Pasteur), 130C.-272.Google Scholar
  2. Bona, C., Paul, W.E., 1979, Cellular basis of expression of idiotypes, J. Exp. Med., 149:532.Google Scholar
  3. Bona, C., Hiernaux, J. 1981, Immune response: idiotype anti-idiotype network, CRC Crit. Rev. Immunol.. 2:33.Google Scholar
  4. Bothwell, A., Paskino, M., Reth, M., Imanishi, T., Rajewsky, K., Baltimore, A., 1981, Heavy-chain variable region contribution to the NP family of antibodies somatic mutation evident in a 2a variable region, Cell, 24:625.PubMedCrossRefGoogle Scholar
  5. Bretscher, P., Conn, M., 1970, A theory of self-non self discrimination, Science., 169:1042.PubMedCrossRefGoogle Scholar
  6. Cazenave, P.A., 1977, Idiotypic antiidiotypic regulation of antibody synthesis in rabbits, Proc. Natl. Acad. Sci., USA, 74:5122.Google Scholar
  7. Cohn, M. 1981, Commentary. Conversation with N.K. Jerne on Immune Regulation: associative versus network recognition, Cellular Immunology, 61: 425.PubMedCrossRefGoogle Scholar
  8. Doria, G., Schiaffini, G., Garavini, H., Mancini, C., 1972, The rise and fall of antibody avidity at the level of single immunocytes, J. Immunol., 109:1245.PubMedGoogle Scholar
  9. Flood, P., Kripke, M., Fowley, D., Schreiber, H., 1980, Suppression of tumor rejection by autologous antiidiotypic immunity. Proc. Natl. Acad. Sci., USA, 77:2209.Google Scholar
  10. Jerne, N.K., 1974, Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur), 125C:373.Google Scholar
  11. Schaaf-Lafontaine, N., 1978, Separation of lymphoid cells with a suppression effect on the activity of cytotoxic cells in vitro during the growth of a syngeneic mouse tumor, Int. J. Cancer, 21:329.PubMedCrossRefGoogle Scholar
  12. Tasiaux, N., Leuwenkroon, R., Bruyns, C., Urbain, J., 1978, Possible occurrence and meaning of lymphocytes bearing auto-anti-idiotypic receptors during the immune response, Eur. J. Immunol., 8:464.Google Scholar
  13. Tilkin, A.F., Schaaf-Lafontaine, N., Van Acker, A., Boccadoro, M., Urbain, J., 1981, Reduced tumor growth after low dose irradiation or immunization against blastic suppressor T cell, Proc. Natl. Acad. Sci., USA, 78:1809.Google Scholar
  14. Urbain, J., Van Acker, A., De Vos-Cloetens, C., Urbain-Vansanten, G., 1972, Increase and decrease in binding affinity of antido-dies during the immune response, Immunochemistry, 9:121.PubMedCrossRefGoogle Scholar
  15. Urbain, J., 1974, Cellular recognition and evolution, Arch. Biol., 85:139.Google Scholar
  16. Urbain, J., Wikler, M., Franssen, J.D., Collignon, C., 1977, Idiotypic regulation of the immune system by the induction of antibodies against antiidotypic antibodies, Proc. Natl. Acad. Sci., USA, 74:5126.Google Scholar
  17. Urbain, J., Cazenave, P.A., Wikler, M., Franssen, J.D., Mariame, B., Leo, O., 1980, Idiotypic induction and immune networks, in: “Immunology 1980”, Dausset, J. and Fougereau M., eds., Acad. Press., New York, p. 81.Google Scholar
  18. Urbain, J., Wuilmart, C., Cazenave, P.A., 1981, Idiotypic networks in immune regulation, Contemp. Topics in Molecular Immunology, 8:113.Google Scholar
  19. Wikler, M., Franssen, J.D., Collignon, C., Leo, O., Mariame, B., Van de Walle, P., De Groote, D., Urbain, J., 1979, Idiotypic regulation of the immune system, J. Exp. Med., 150:184.Google Scholar
  20. Wikler, M., Demeur, C., Dewasme, G., Urbain, J., 1980, Immunore-gulatory role of maternal idiotypes. Ontogeny of immune networks, J. Exp. Med., 152:1024.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. Urbain
    • 1
  1. 1.Lab. of Animal Physiology 67Université Libre de BruxellesRhode-St-GèneseBelgium

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