Abstract
Although supported by a lot of data it is fair to say that the idiotype network hypothesis is not universally accepted. This is partly due to the fact that many people do not talk about the same things even when they use the same words. Furthermore, different contradictory models have been put forward.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Binz, H., Frischknecht, H., Wigzell, H.,1979, Some studies on idiotypes and antiidiotypic reactions and receptors in antiallo-MHC T cells immunity, Ann. Immunol. (Inst.Pasteur), 130C.-272.
Bona, C., Paul, W.E., 1979, Cellular basis of expression of idiotypes, J. Exp. Med., 149:532.
Bona, C., Hiernaux, J. 1981, Immune response: idiotype anti-idiotype network, CRC Crit. Rev. Immunol.. 2:33.
Bothwell, A., Paskino, M., Reth, M., Imanishi, T., Rajewsky, K., Baltimore, A., 1981, Heavy-chain variable region contribution to the NP family of antibodies somatic mutation evident in a 2a variable region, Cell, 24:625.
Bretscher, P., Conn, M., 1970, A theory of self-non self discrimination, Science., 169:1042.
Cazenave, P.A., 1977, Idiotypic antiidiotypic regulation of antibody synthesis in rabbits, Proc. Natl. Acad. Sci., USA, 74:5122.
Cohn, M. 1981, Commentary. Conversation with N.K. Jerne on Immune Regulation: associative versus network recognition, Cellular Immunology, 61: 425.
Doria, G., Schiaffini, G., Garavini, H., Mancini, C., 1972, The rise and fall of antibody avidity at the level of single immunocytes, J. Immunol., 109:1245.
Flood, P., Kripke, M., Fowley, D., Schreiber, H., 1980, Suppression of tumor rejection by autologous antiidiotypic immunity. Proc. Natl. Acad. Sci., USA, 77:2209.
Jerne, N.K., 1974, Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur), 125C:373.
Schaaf-Lafontaine, N., 1978, Separation of lymphoid cells with a suppression effect on the activity of cytotoxic cells in vitro during the growth of a syngeneic mouse tumor, Int. J. Cancer, 21:329.
Tasiaux, N., Leuwenkroon, R., Bruyns, C., Urbain, J., 1978, Possible occurrence and meaning of lymphocytes bearing auto-anti-idiotypic receptors during the immune response, Eur. J. Immunol., 8:464.
Tilkin, A.F., Schaaf-Lafontaine, N., Van Acker, A., Boccadoro, M., Urbain, J., 1981, Reduced tumor growth after low dose irradiation or immunization against blastic suppressor T cell, Proc. Natl. Acad. Sci., USA, 78:1809.
Urbain, J., Van Acker, A., De Vos-Cloetens, C., Urbain-Vansanten, G., 1972, Increase and decrease in binding affinity of antido-dies during the immune response, Immunochemistry, 9:121.
Urbain, J., 1974, Cellular recognition and evolution, Arch. Biol., 85:139.
Urbain, J., Wikler, M., Franssen, J.D., Collignon, C., 1977, Idiotypic regulation of the immune system by the induction of antibodies against antiidotypic antibodies, Proc. Natl. Acad. Sci., USA, 74:5126.
Urbain, J., Cazenave, P.A., Wikler, M., Franssen, J.D., Mariame, B., Leo, O., 1980, Idiotypic induction and immune networks, in: “Immunology 1980”, Dausset, J. and Fougereau M., eds., Acad. Press., New York, p. 81.
Urbain, J., Wuilmart, C., Cazenave, P.A., 1981, Idiotypic networks in immune regulation, Contemp. Topics in Molecular Immunology, 8:113.
Wikler, M., Franssen, J.D., Collignon, C., Leo, O., Mariame, B., Van de Walle, P., De Groote, D., Urbain, J., 1979, Idiotypic regulation of the immune system, J. Exp. Med., 150:184.
Wikler, M., Demeur, C., Dewasme, G., Urbain, J., 1980, Immunore-gulatory role of maternal idiotypes. Ontogeny of immune networks, J. Exp. Med., 152:1024.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Plenum Press, New York
About this chapter
Cite this chapter
Urbain, J. (1983). Is the Immune System a Functional Idiotypic Network?. In: Fabris, N., Garaci, E., Hadden, J., Mitchison, N.A. (eds) Immunoregulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4547-3_7
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4547-3_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4549-7
Online ISBN: 978-1-4684-4547-3
eBook Packages: Springer Book Archive