Immunoregulation of “In Vitro” Antibody Response to Azobenzenearsonate (ABA)-Proteins
The impact of exogenous antigen on the immune system activates a complex series of events which determine the onset, intensity, and duration of the antibody response. This antigen-induced perturbation of the immune system, which leads to antibody production by B cells, involves antigen-presentation by accessory cells and activation of immunoregulatory T cells with helper, suppressor, or amplifier function. Idiotypes and anti-idiotypes are major recognition structures shared by cells and soluble factors interacting in each immunoregulatory circuit (Herzenberg et al., 1980). The intriguing complexity of immunoregulation stimulated the interest of several outstanding immunologists who have produced in recent years an enormous amount of information on a few immunoregulation system. The immune response to azoben-zenearsonate (ABA) is one of these well defined systems which has been intensively investigated “in vivo” by Nisonoff’s and Bena-cerraf’s groups, at the levels of both antibody production and delayed-type hypersensibility (Nisonoff and Greene, 1980).
KeywordsAntibody Response Spleen Cell Keyhole Limpet Hemocyanin Popliteal Lymph Node Thymic Involution
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