Immunogenetic Determinants Controlling the Metastatic Properties of Tumor Cells
The generation of metastases by tumor cells is preceeded by a sequence of processes, each of which is controlled by different properties of the invading cells. Thus, the detachment of tumor cells from its local population might be associated with alterations in cell-to-cell recognition patterns, its metastatic penetration through the basement membrane of blood capillaries might require the synthesis of specific enzymes capable of degrading membrane proteins (Liotta et al., 1977; Strauli and Weiss, 1977), its “homing” to specific organs might be determined by specific adherance to the normal cells of the target organ (Kramer and Nicolson, 1979), whereas its growth at its new site might require the secretion of angiogenic factors (Folkman and Hochberg, 1973; Folkman and Handeschild, 1981).
KeywordsLung Metastasis Metastatic Property Experimental Lung Metastasis Subcutaneous Transplantation Clone Tumor Cell
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