Accelerated Aging in Down’s Syndrome: The Concept of Hierarchical Homeostasis in Relation to Local and Global Failure

  • Roy L. Walford
  • Faramarz Naeim
  • Kathleen Y. Hall
  • C. F. Tam
  • Richard A. Gatti
  • Michael A. Medici


A number of diseases are known to manifest various features of accelerated aging, including progeria, Werner’s syndrome, most of the chromosomal instability syndromes (Gatti and Walford, 1981), various other maladies (Martin, 1978) and — reflecting our own particular interests — systemic lypus erythematosus (SLE) (Barnett et al., 1981) and Down’s syndrome (DS) (Walford et al., 1981). Table 1 lists a number of the non-immune hallmarks of aging as seen normally and in various diseases characterized in part by accelerated aging. DS demonstrates many features of accelerated aging: premature greying of hair, degenerative vascular disease, amyloidosis, hypogonadism, senile dementia of the Alzheimer’s type, immune dysfunction, possibly an increased susceptibility to diabetes, and decreased replicative capacity of fibroblasts, among others.


Accelerate Aging Energy Charge Purine Nucleoside Phosphorylase Systemic Lupus Erythe Thymic Hormone 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Roy L. Walford
    • 1
  • Faramarz Naeim
  • Kathleen Y. Hall
  • C. F. Tam
  • Richard A. Gatti
  • Michael A. Medici
  1. 1.The Department of Pathology, UCLA Medical School and Pediatric OncologyCedars-Saint HospitalLos AngelesUSA

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