Muscular Dystrophies and Thymic Deficiency

  • David F. Horrobin


The association between the thymus and the muscle has been intensively investigated in the case of “myasthenia gravis”. The evidence that in some patients with “myasthenia gravis” there may be an excess of thymic function tended to point investigators in the direction of looking for excess thymic activity in muscular dystrophy also. However, in 1964, Walker demonstrated that neonatal thymectomy failed to influence the course of murine muscular dystrophy. This was thought to rule out the idea that excess thymus activity might be involved, at least in the mouse model of muscular dystrophy. It was a decade before interest was again aroused in the muscular dystrophy/thymus relationship.


Muscular Dystrophy Duchenne Dystrophy Myotonic Dystrophy Dwarf Mouse Thymus Atrophy 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • David F. Horrobin
    • 1
  1. 1.Efamol Research InstituteKentvilleCanada

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