The association between the thymus and the muscle has been intensively investigated in the case of “myasthenia gravis”. The evidence that in some patients with “myasthenia gravis” there may be an excess of thymic function tended to point investigators in the direction of looking for excess thymic activity in muscular dystrophy also. However, in 1964, Walker demonstrated that neonatal thymectomy failed to influence the course of murine muscular dystrophy. This was thought to rule out the idea that excess thymus activity might be involved, at least in the mouse model of muscular dystrophy. It was a decade before interest was again aroused in the muscular dystrophy/thymus relationship.
KeywordsMuscular Dystrophy Duchenne Dystrophy Myotonic Dystrophy Dwarf Mouse Thymus Atrophy
Unable to display preview. Download preview PDF.
- Basch, K., 1906, Beitrage zur Physiologie und Pathologie der Thymus, Jahrb, Kinderhilk, 64:285.Google Scholar
- Colby-Germinario, S., Martial, E., and Livett, B.G., 1981, Delayed graft rejection in murine muscular dystrophy: a hypothesis concerning the role of the thymus in neuromuscular disease, J. Neuroimmunol., in press.Google Scholar
- Comsa, J., 1938, Consequences de la thymectomie totale chez le cobaye male, C.R. Soc. Biol., 27:903.Google Scholar
- Harms, J.W., 1952, Experimentell-morphologische Untersuchungen uber den Thymus von Xenopus leavis, Daudin. Gegemb. Morphol. Jahrb., 92:256.Google Scholar
- Horrobin, D.F., and Karmali, R.A., 1975, Effects of bromocriptine and prolactin on thymus growth and thymus uptake of tritiated thymidine in mice of the Swiss and Bar Harbor 129 strains, J. Endocr., 67:58.Google Scholar
- Horrobin, D.F., and Lieb, J., 1981, A biochemical basis for the actions of lithium on behaviour and on immunity, Med. Hypotheses, 7:899.Google Scholar
- Karim, S.M.M., Sandler, M., and Williams, E.D., 1967, Distribution of prostaglandis in human tissues, Br. J. Pharmacol., 31:340.Google Scholar
- Livett, B.G., Colby-Germinario, S.P., Mizobe, F., and Martial, E., 1981, Plasma membrane and immunocyte involvement in the muscular dystrophies: evidence for a developmental abnormality in cell mediated immunity, International Conference Series, Vol. 146, Excerpta Medica Foundation, Amsterdam, in press.Google Scholar
- Miller, J.F.A.P., 1962, Effect of thymic ablation and replacement, in: “The Thymus in Immunobiology,” R.A. Good and A.E. Gabrielsen, eds., Hoeber, New York, p. 436.Google Scholar
- Parrott, D.M.V., and East, J., 1962, Studies on a fatal wasting syndrome of mice thymectomized at birth, in: “The Thymus in Immubiology,” R.A. Good and A.E. Gabrielsen, eds., Hoeber, New York, p. 523.Google Scholar
- Pora, E., and Toma, V.V., 1960, Action des extraits de thymus sur le gastrocremien de grenouille intoxique aux acides lactiques our monoiodoacetiques ou par le fatigue, Stud. Cercet. Biol. Ser. Zool., 12:285.Google Scholar
- Szewcuk, M.R., 1980, Abnormal age-associated immunoregulation in muscular dystrophic mice, Canad. J. Neurol. Sci., 7: 124.Google Scholar
- Walker, B.E., 1964, Mast cells, thymectomy and tumor rejection in dystrophic mice, Texas Rep. Biol. Med., 22:640.Google Scholar