Myasthenia Gravis: Thymic and Peripheral Blood Cell Interactions in Specific Antibody Production

  • John Newsom-Davis


Myasthenia gravis is a disorder of neuromuscular transmission in which antibody is produced to the skeletal muscle receptor for the neurotransmitter acetylcholine. It is thus one of a group of autoimmune disorders predicted by Lennon and Carnegie (1971) and now increasingly being recognised, in which cell surface receptors to peptide hormones or neurotransmitters become the target for autoantibodies. Other examples of diseases which show this feature are thyrotoxicosis and some forms of diabetes.


Acetylcholine Receptor Antibody Production Germinal Centre Pokeweed Mitogen Thymic Hyperplasia 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John Newsom-Davis
    • 1
  1. 1.Department of Neurological ScienceRoyal Free Hospital School of MedicineLondonEngland

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