Neuroendocrine Immunoregulation

  • Hugo O. Besedovsky
  • Adriana del Rey
  • Ernst Sorkin


Considerable advances have been made in understanding the cellular elements of the immune system, antibody structure, and the generation of antibody diversity at the genetic and somatic level. How immunological cells, antibodies and other cell products interact and how these interactions are regulated have now become major issues. In view of the enormous complexity of the immune system, it is hardly surprising that different levels of regulation exist such as antibody feedback, idiotypic-anti-idiotypic responses, suppressor and helper T-cells, lymphokine signals and genetic requirements. The common feature of these control mechanisms is that they are based on interactions involving elements of the immune system itself.


Firing Rate Accessory Cell Hypothalamic Neuron Plaque Form Cell Serum Corticosterone Level 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Hugo O. Besedovsky
    • 1
  • Adriana del Rey
    • 1
  • Ernst Sorkin
    • 1
  1. 1.Medical DepartmentSwiss Research InstituteDavosSwitzerland

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