Subpopulations of Human Lymphocytes and their Alterations in Immunodeficiency Diseases

  • Max D. Cooper
  • Toru Abo
  • Willem A. Kamps
  • Patricia L. Haber
  • Charles M. Balch


The two major lines of immunocompetent cells, T and B cells, are thought to derive from a common lymphoid precursor or more directly from the multipotent hemopoietic stem cell. For both T and B cells, it is clear that special inductive microenvironments play important roles in the initiation of their separate differentiation pathways. The epithelial thymus serves both as a generation site for T cells and as a source of hormones that can modulate proliferation and function of T cells even after they enter the circulation to migrate through peripheral lymphoid tissues. The inductive micro-environments for the B cell pathway in mammals are not as sharply delineated, and these change during development. The fetal liver is an early site of B cell generation, and bone marrow assumes this function later. Much has been learned about the details of the development and differentiation of functionally diverse subpopulations of T and B cells in recent years, and practical markers are now available for the study of these processes in humans.


Severe Combine Immunodeficiency Primary Immunodeficiency Disease DIGEORGE Syndrome Primary Antibody Deficiency Immunoglobulin Deficiency 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Max D. Cooper
    • 1
  • Toru Abo
    • 1
  • Willem A. Kamps
    • 1
  • Patricia L. Haber
    • 1
  • Charles M. Balch
    • 1
  1. 1.The Cellular Immunobiology Unit of the Tumor Inst. Depts. of Pediatrics, Surgery and Microbiology, and The Comprehensive Cancer CenterUniversity of Alabama in BirminghamAlabamaUSA

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