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Immunoendocrinology : Endocrine Aspects of Autoimmune Disease

  • Norman Talal

Abstract

There are important bidirectional relationships between the immune and endocrine systems (Talal, 1978). Our laboratory became interested in these relationships through investigations seeking an explanation for the marked female predominance of autoimmune disorders such as systemic lupus erythematosus (SLE). The female to male ratio in SLE is 15:1 during the childbearing ages and decreases to 2:1 after menopause (Talal, 1979). Furthermore, in Klinefelter’s syndrome (XXY) in which genetic males develop gynecomastia and sparse body hair, there is an increased incidence of autoimmune disorders such as SLE and myasthenia gravis (Michalski et al., 1978). These clinical observations led us to speculate that sex hormones might play an important role in the pathogenesis of autoimmune disease.

Keywords

Systemic Lupus Erythematosus Murine Lupus Human Systemic Lupus Erythematosus Thymic Epithelium Endocrine Aspect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andrews, B.S., Eisenberg, R.A., Theofilopoulos, A.N., Izui, S., Wilson, C.B., McConahey, P.J., Murphy, E.D., Roths, J.B., and Dixon, F.J., 1978, Spontaneous murine lupus-like syndromes: I. Clinical and immunopathological manifestations in several strains, J. Exp. Med., 148:1148.CrossRefGoogle Scholar
  2. Besedovsky, H., and Sorkin, E., 1977, Network of immune-neuroendocrine interactions, Clin. Exp. Immunol., 27:1.PubMedGoogle Scholar
  3. Conn, D.A., 1979, High sensitivity to androgen as a contributing factor in sex differences in the immune response, Arthritis Rheum., 22:1218.CrossRefGoogle Scholar
  4. Creighton, W.D., Katz, D.H., and Dixon, F.J., 1979, Antigen-specific immunocompetency, B cell function, and regulatory helper and suppressor T cell activities in spontaneously autoimmune mice, J. Immunol., 123:2627.Google Scholar
  5. Dauphinee, M.J., Kipper, S.B., Wofsy, D., and Talal, N., Interleukin-2 deficiency is a common feature of autoimmune mice, manuscript submitted.Google Scholar
  6. Dauphinee, M.J., Kipper, S.B., Roskos, K., Wofsy, D., and Talal, N., 1980, Androgen treatment of autoimmune NZB/W mice enhances IL-2 production, Arthritis Rheumatism Association Meeting, Boston, MA, abstr.Google Scholar
  7. Farrar, J.J., Simon, P.L., Koopman, W.J., and Fuller-Bonar, J., 1978, Biochemical relationship of thymocyte mitogenic factor and factors enhancing humoral and cell-mediated immune responses, J. Immunol., 121:1353.PubMedGoogle Scholar
  8. Gershon, R.K., Horowitz, M., Kemp, J.D., Murphy, D.B., and Murphy, E.D., 1978, The cellular site of immunoregulatory breakdown in the lpr mutant mouse, in “Genetic Control of Autoimmune Disease,” N.R. Rose, P.E. Bigazzi, and N.L. Warner, eds, Elsevier, North Holland, New York, p. 223.Google Scholar
  9. Gillis, S., Ferm, M.M., Ou, W., and Smith, K.S., 1978, T cell growth factor parameters of production and a quantitative microassay for activity, J. Immunol., 120:2027.PubMedGoogle Scholar
  10. Gillis, S., Baker, P.E., Ruscetti, F.W., and Smith, K.A., 1978, Long-term culture of human antigen-specific cytotoxic T-cell lines, J. Exp. Med., 148:1093.PubMedCrossRefGoogle Scholar
  11. Glimcher, L.H., Steinberg, A.D., House, S.B., and Green, I., 1980, The autologous mixed lymphocyte reaction in strains of mice with autoimmune disease, J. Immunol., 124:1832.Google Scholar
  12. Horn, J.T., and Talal, N., Disordered immunologic regulation, in: “Immuno-Dynamics,” III. R.S. Krakauer, ed., Elsevier, North Holland/NY, in press.Google Scholar
  13. Izui, S., and Eisenberg, R.A., 1980, Circulating anti-DNA rheumatoid factor complexes in MRL/1 mice, Clin. Immunol. Immunopathol., 15:535.CrossRefGoogle Scholar
  14. Kruisbeck, A.M., Zijlstra, J.J., and Krose, T.J.M., 1980, Distinct effects of T cell growth factors and thymic epithelial factors on the generation of cytotoxic T lymphocytes by thymocyte sub-populations, J. Immunol., 125:995.Google Scholar
  15. Lahita, R.G., Bradlow, H.L., Kunkel, H.., and Fishman, J., 1979, Alterations of estrogen metabolism in systemic lupus erythematosus, Arthritis Rheum., 22: 1195.PubMedCrossRefGoogle Scholar
  16. Michalski, J.P., Synder, S.M., McLeod, R.L., and Talal, N., 1978, Monozygotic twins with Klinefelter’s syndrome discordant for systemic lupus erythematosus and symptomatic myasthenia gravis, Arthritis Rheum., 21:306.PubMedCrossRefGoogle Scholar
  17. Murphy, E.D., and Roths, J.B., 1978, Autoimmunity and lymphoproliferation: Induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB, in: “Genetic Control of Autoimmune Disease,” N.R. Rose, P.E. Bigazzi, and N.L. Warner, eds., Elsevier, North Holland/New York, p. 207.Google Scholar
  18. Nicol, T., Vernon-Roberts, B., and Quantock, D.C., 1966, Estrogenic and anti-estrogenic effect of estriol, 16-epioestriol, 2-metho-cytosterone and 2-hydroeyoestradiol, 17-beta on the reticuloendothelial system and reproductive tract, J. Endocrinol., 35:119.PubMedCrossRefGoogle Scholar
  19. Pierpaoli, W., and Maestroni, J.M., 1978, Pharmacologic control of the hormonally modulated immune response. III. Prolongation of allogeneic skin graft rejection and prevention of runt disease by a combination of drugs acting on neuroendocrine functions, J. Immunol., 120:1600.PubMedGoogle Scholar
  20. Rogers, M.P., Dubey, D., Reich, P., 1979, The influence of psyche and the brain on immunity and disease susceptibility: A critical review, Psychosom. Med., 41:147.Google Scholar
  21. Roubinian, J.R., Papoian, R., and Talal, N., 1977, Androgenic hormones modulate autoantibody responses and improve survival in murine lupus, J. Clin. Invest., 59:1066.PubMedCrossRefGoogle Scholar
  22. Roubinian, J.R., Talal, N., Greenspan, J.S., Goodman, J.R., and Siiteri, P.K., 1978, Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F mice, J. Exp. Med., 147:1568.PubMedCrossRefGoogle Scholar
  23. Roubinian, J.R., and Talal, N., Greenspan, J.S., Goodman, J.R., and Siiteri, P.K., 1979, Delayed androgen treatment prolongs survival in murine lupus, J. Clin. Invest, 63:902.PubMedCrossRefGoogle Scholar
  24. Roubinian, J.R., Talal, N., Greenspan, J.S., Goodman, J.R., and Nussenzweig, V., 1979, Danazol’s failure to suppress autoimmunity in NZB/NZW F mice, Arthritis Rheum., 22:1399.PubMedCrossRefGoogle Scholar
  25. Sawada, S., and Talal, N., 1979, Evidence for a helper cell promoting anti-DNA antibody production in murine lupus, Arthritis Rheum., 22:655, abstr.Google Scholar
  26. Shaw, J., Monticone, V., Mills, G., and Paetkau, V., 1978, Effects of costimulator on immune responses in vitro, J. Immunol., 120:1974.PubMedGoogle Scholar
  27. Shear, H.L., Roubinian, J.R., Gil, P., and Talal, N., 1981, Clearance of sensitized erythrocytes in NZB/NZW mice. Effects of castration and sex hormone treatment, Eur. J. Immunol., in press.Google Scholar
  28. Steinberg, A.D., Melez, K.A., Raveche, E.S., Reeves, J.P., Boegel, W.A., Smathers, P.A., Taurog, J.D., Weinlein, L., and Duvic, M., 1979, Approach to the study of the role of sex hormones in autoimmunity, Arthritis Rheum., 22:1170.PubMedCrossRefGoogle Scholar
  29. Steinberg, A.D., Roths, J.B., Murphy, E.D., Steinberg, R.T., and Raveche, E.S., 1980, Effects of thymectomy or androgen administration upon the auto-immune disease of MRL/Mp-lpr/lpr mice, J. Immunol., 125:871.PubMedGoogle Scholar
  30. Stumpf, W.E., and Sar, M., 1976, Receptors and mechanism of action of steroid hormones, in: “Modern Pharmacology-Toxicology,” J. Pasqualini, ed., Marcel Dekker, New York, p. 41.Google Scholar
  31. Talal, N., 1978, Autoimmunity and the immunologic network, Arthritis Rheum., 21:853.PubMedCrossRefGoogle Scholar
  32. Talal, N., 1979, Systemic lupus erythematosus, autoimmunity, sex and inheritance, N. Engl. J. Med., (editorial), 301:838.PubMedCrossRefGoogle Scholar
  33. Talal, N., 1976, Discordered immunologic regulation and autoimmunity. Transplant. Rev., 31:240.PubMedGoogle Scholar
  34. Talal, N., Roubinian, J.R., Daupinee, M.J., Jones, L.A., and Siiteri, P.K., 1981, Effects of sex hormones on spontaneous autoimmune disease in NZB/NZW hybrid mice, in: “Advances in Immunopharmacology,” J. Hadden et al., eds., Pergamon Press, Oxford and New York, p. 127.Google Scholar
  35. Talal, N., Roubinian, J.R., Shear, H., Horn, J.T., Miyasaka, N., 1980, Progress in the mechanisms of autoimune disease, in: “Immunology-1980,” M. Fougereau, ed., Academic Press, Inc., London Ltd., p. 889.Google Scholar
  36. Theofilopoulos, A.N., Eisenberg, R.A., Bourdon, M., Crowell, J.S., Jr., and Dixon, F.G., 1979, Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes, J. Exp. Med., 149:516.PubMedCrossRefGoogle Scholar
  37. Theofilopoulos, A. N., Shawler, D.L., Eisenberg, R.A., and Dixon, F.J., 1980, Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice, J. Exp. Med., 151:446.PubMedCrossRefGoogle Scholar
  38. Watson, J., Gillis, S., Marbrook, J., Mochizuki, D., amd Smith, K.A., 1979, Biochemical and biological characterization of lymphocyte regulatory molecules, I. Purification of a class of murine lym. phokines, J. Exp. Med., 150:849.PubMedCrossRefGoogle Scholar
  39. Watson, J., Aarden, L.A., Shaw, J., and Paetkau, V., 1979, Molecular and quantitative analysis of helper T cell-replacing factors on the induction of antigen-sensitive B lymphocytes, J. Immunol., 122:1633.PubMedGoogle Scholar
  40. Watson, J., 1979, Continuous proliferation of murine antigen-specific helper T lymphocytes in culture, J. Exp. Med., 150:1510.PubMedCrossRefGoogle Scholar
  41. Wofsy, D., Dauphinee, M.J., Kipper, S.B., Roths, J.B., Murphy, E.D., and Talal, N., 1981, Deficient Interleukin-2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene, manuscript submitted.Google Scholar
  42. Wybran, J., Apperboom, T., Famaey, J-P., and Govaerts, A., 1979, Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes, J. Immunol., 122:1068.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Norman Talal
    • 1
  1. 1.Medical CentreClinical Division ImmunologySan FranciscoUSA

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