Cyclic Nucleotides and Related Mechanisms in Immune Regulation : A Mini Review

  • John W. Hadden


Much of the study of immune regulation over the last twenty years has focused on the dissection of cellular function and interactions “in vitro”. While clearly “in vivo” studies have supported the models of regulation which have derived, this type of extrapolative approach tells only part of the story of immune regulation. The “in vitro” studies generally employ artificial media containing a drab of serum often from different species; they do not pretend to offer a dynamic fluid environment akin to that which exists “in vivo”. It is becoming abundantly clear that the immune system operates “in vivo” within a homeostatic milieu replete with neurologic, neuroendocrine, endocrine and microenvi-ronmental regulatory influences clearly as complex as those regulating the internal network of intercommunication among the cells of the system.


Migration Inhibitory Factor Cyclic Nucleotide Guanylate Cyclase Immune Regulation Arachidonic Acid Release 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John W. Hadden
    • 1
  1. 1.Laboratory of ImmunopharmacologyMemorial Sloan Kettering Cancer CenterNew YorkUSA

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