Lymphokines and the Lymphoendothelial System : An Illustration of Immunoregulatory Integration

  • D. C. Dumonde
  • Anne S. Hamblin
  • Eva Kasp-Grochowska
  • Melanie S. Pulley
  • R. A. Wolstencroft


The possibility that non-antibody products of lymphocyte activation might be involved in the expression and regulation of lymphocyte function arose indirectly from consideration of the role of lymphocytes and macrophages in experimental delayed hypersensitivity (Dumonde, 1967; Dumonde et al., 1968). Analysis of experimental cell-mediated immune phenomena had pointed to the role of cellular interactions between a few specifically sensitized lymphocytes and the majority of other host cells participating in these responses (see Turk, 1967). These features were consistent with the concept that special ‘mediators’ of cellular immunity could well facilitate such interactions; and that this would bring the cellular immune system into line with other biological systems in which differentiated cell products (for example endocrine and neurotransmitter substances) were known to mediate complex physiological events.


Acute Phase Protein Lymphocyte Activation Advanced Cancer Patient Lymphoid Cell Line Ciba Foundation Symposium 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • D. C. Dumonde
    • 1
  • Anne S. Hamblin
    • 1
  • Eva Kasp-Grochowska
    • 1
  • Melanie S. Pulley
    • 1
  • R. A. Wolstencroft
    • 1
  1. 1.Department of ImmunologySt Thomas’s Hospital and Medical SchoolLondonUK

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