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Fine Specificity of H-2-Restricted, Lysozyme Specific Suppressor T Cell Factor

  • Luciano Adorini
  • Carlo Pini
  • Camillo Mancini
  • Gino Doria
  • Paola Ricciardi-Castagnoli

Abstract

Antigen-specific T cells play a major role in the complex network of cellular interactions which regulate the immune response. These cellular interactions are mediated by soluble factors which may represent antigen-specific T cell recognition structures. T cell factors induced by different antigens have several features in common: they are antigen-specific, bear I-region encoded and idiotypic determinants, lack immunoglobulin constant region determinants and their molecular weight is usually in the range of 50,000 – 70,000 daltons. However, the structural definition and the precise immunoregulatory function of the antigen-specific T cell receptor is still unclear largely because, until recently, antigen-specific, functional T cell clones were not available. Substantial progresses towards the biochemical and functional characterization of antigen-specific T cell products cannot be achieved by studies of conventional T cell populations because of the low frequency of antigen-specific T cells, the short life span of lymphocytes and the heterogeneity of T cell subsets.

Keywords

Fine Specificity BDF1 Mouse Antigen Priming Factor Injection Idiotypic Determinant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Luciano Adorini
    • 1
  • Carlo Pini
    • 2
  • Camillo Mancini
    • 1
  • Gino Doria
    • 1
  • Paola Ricciardi-Castagnoli
    • 3
  1. 1.Laboratory of Radiopathology, C.N.S. CasacciaCNEN-Euratom Immunogenetics GroupRomaItaly
  2. 2.Laboratory of Cell Biology and ImmunologyIstituto Superiore di SanitàRomaItaly
  3. 3.CNR Center of Cytopharmacology, Department of PharmacologyUniversity of MilanoMilanoItaly

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