Abstract
Antigen-specific T cells play a major role in the complex network of cellular interactions which regulate the immune response. These cellular interactions are mediated by soluble factors which may represent antigen-specific T cell recognition structures. T cell factors induced by different antigens have several features in common: they are antigen-specific, bear I-region encoded and idiotypic determinants, lack immunoglobulin constant region determinants and their molecular weight is usually in the range of 50,000 – 70,000 daltons. However, the structural definition and the precise immunoregulatory function of the antigen-specific T cell receptor is still unclear largely because, until recently, antigen-specific, functional T cell clones were not available. Substantial progresses towards the biochemical and functional characterization of antigen-specific T cell products cannot be achieved by studies of conventional T cell populations because of the low frequency of antigen-specific T cells, the short life span of lymphocytes and the heterogeneity of T cell subsets.
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Adorini, L., Miller, A., and Sercarz, E.E., 1979a, The fine specificity of regulatory T cells. I. Hen egg-white lysozyme-induced suppressor T cells in a genetically non responder mouse strain do not recognize a closely related immunogenic lysozyme, J. Immunol., 122:871.
Adorini, L., Harvey, M., Miller, A., and Sercarz, E.E., 1979b, The fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme (HEL) in a gentically non responder mouse strain, J. Exp. Med., 150:293.
Adorini, L., Harvey, M.A., Rozyka-Jackson, D., Miller, A., and Sercarz, E.E., 1980, Differential major histocompatibility complex-related activation of idiotypic suppressor T cells. Suppressor T cells cross-reactive to two distantly related lysozyme are not induced by one of them,J. Exp. Med., 152:521.
Adorini, L., Doria, G. and Ricciardi-Castagnoli, P., 1981, Biochemical and functional analysis of antigen-specific products obtained from virus-transformed, lysozyme-specific suppressor T cell lines, Lymphokines, in press.
Finn, O.J., Boniver, J., and Kaplan, H.S., 1979, Induction, establishment “in vitro”, and characterization of functional, antigen-specific, carrier-primed murine T cell lymphomas, Proc. Natl. cad. Sci., USA, 76:4033.
Fresno, M., McVay-Boudreau, L., Furthmayer, H., and Cantor, H., 1981, Antigen-specific T lymphocyte clones. II. Purification and biological characterization of an antigen-specific suppressive protein synthesized by cloned T cells, J. Exp. Med., 153:1260.
Germain, R.N., and Benacerraf, B., 1980, Helper and suppressor T cell factors, Springer Semin. Immunopathol., 3:93.
Harvey, M.A., Adorini, L., Miller, A., and Sercarz, E.E., 1979, Lysozyme induced T suppressor cells and antibodies bear a predominant idiotype, Nature, 281:594.
Hill, S.W., and Sercarz, E.E., 1975, Fine specificity of the H-2 linked immune response gene for the gallinaceous lysozyme, Eur. J. Immunol., 5:317.
Ricciardi-Castagnoli, P., Lieberman, M., Finn, O., and Kaplan, H.S., 1978, T-cell lymphoma induction by radiation leukemia virus in athymic nude mice, J. Exp. Med., 148:1292.
Ricciardi-Castagnoli, P., Doria, G., and Adorini, L., 1981, Production of antigen-specific suppressive T cell factor by radiation leukemia virus-transformed suppressor T cells, Proc. Natl. Acad. Sci., USA, in press.
Sercarz, E.E., Yowell, R.L., Turkin, D., Miller, A., Araneo, B.A., and Adorini, L., 1978, Different functional specificity repertoire for suppressor and helper T cells, Immunological Rev., 39:108.
Taniguchi, M., Takei, I., and Tada, T., 1980, Functional and molecular organization of an antigen-specific suppressor factor from a T-cell hybridoma, Nature, 283:227.
Yowell, R.L., Araneo, B.A., Miller, A., and Sercarz, E.E., 1979, Amputation of a suppressor determinant on lysozyme reveals underlying T-cell reactivity to other determinants, Nature, 279:70.
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© 1983 Plenum Press, New York
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Adorini, L., Pini, C., Mancini, C., Doria, G., Ricciardi-Castagnoli, P. (1983). Fine Specificity of H-2-Restricted, Lysozyme Specific Suppressor T Cell Factor. In: Fabris, N., Garaci, E., Hadden, J., Mitchison, N.A. (eds) Immunoregulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4547-3_10
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DOI: https://doi.org/10.1007/978-1-4684-4547-3_10
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