Fine Specificity of H-2-Restricted, Lysozyme Specific Suppressor T Cell Factor
Antigen-specific T cells play a major role in the complex network of cellular interactions which regulate the immune response. These cellular interactions are mediated by soluble factors which may represent antigen-specific T cell recognition structures. T cell factors induced by different antigens have several features in common: they are antigen-specific, bear I-region encoded and idiotypic determinants, lack immunoglobulin constant region determinants and their molecular weight is usually in the range of 50,000 – 70,000 daltons. However, the structural definition and the precise immunoregulatory function of the antigen-specific T cell receptor is still unclear largely because, until recently, antigen-specific, functional T cell clones were not available. Substantial progresses towards the biochemical and functional characterization of antigen-specific T cell products cannot be achieved by studies of conventional T cell populations because of the low frequency of antigen-specific T cells, the short life span of lymphocytes and the heterogeneity of T cell subsets.
KeywordsLymphoma Leukemia Phenylalanine Lysozyme Thymoma
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