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IgVH and MHC-Restricted Regulatory Circuit in the Immune Response

  • T. Tada
  • G. Suzuki
  • R. Abe
  • Y. Kumagai
  • K. Hiramatsu
  • S. Miyatani

Abstract

The term “immune circuit” has been used to designate a train process of regulatory cell interactions in which the initial input such as antigenic stimulation activates a consecutive series of lymphoid cells finally producing an output which neutralizes the input signal. Thus, it is supposed that antigenic stimulation induces antibody formation, but at the same time it does activate a series of cells that finally suppress the antibody formation. Such an internal regulatory system is maintained by selective interactions between one cell type and the other which are restricted by mutual recognition of polymorphic structures expressed on partner cells.

Keywords

Major Histocompatibility Complex Mutual Recognition Heavy Chain Variable Region Partner Cell Restricting Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • T. Tada
    • 1
  • G. Suzuki
    • 1
  • R. Abe
    • 1
  • Y. Kumagai
    • 1
  • K. Hiramatsu
    • 1
  • S. Miyatani
  1. 1.Department of ImmunologyFaculty of Medicine University of TokyoTokyoJapan

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