Osmoregulatory (Osm) Genes and Osmoprotective Compounds

  • A. R. Strøm
  • D. LeRudulier
  • M. W. Jakowec
  • R. C. Bunnell
  • R. C. Valentine
Part of the Basic Life Sciences book series (BLSC, volume 26)


A series of compounds, including glycine betaine and proline, known to accumulate in plants during osmotic stress, have been found to function as osmoprotective compounds for bacteria. In fulfilling “Koch’s Postulates” for the biological activity of these compounds, they have been found to protect against osmotic stress when added to the growth medium in relatively low concentration, or when synthesized in the cell. Cells may accumulate very high intracellular levels corresponding to the osmolarity of the medium using uptake systems that appear to be osmotically modulated. A proline overproducing mutation conferring osmotic tolerance has been constructed. Molecular cloning of an osmotic tolerance gene has been achieved. A unified concept of osmoregulation in microorganisms, animals and plants is discussed with some possible applications being pointed out.


Osmotic Stress Glycine Betaine Betaine Glycine Enteric Bacterium Osmotic Tolerance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • A. R. Strøm
    • 2
  • D. LeRudulier
    • 3
  • M. W. Jakowec
    • 1
  • R. C. Bunnell
    • 1
  • R. C. Valentine
    • 1
  1. 1.Plant Growth LaboratoryUniversity of CaliforniaDavisUSA
  2. 2.Institute of FisheriesUniversity of TromsøTromsøNorway
  3. 3.Laboratoire de Physiologie VégétaleUniverité de Rennes IRennes CedexFrance

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