Cellular Systems and Aspects of Protein Synthesis in the Study of Muscle Cell Differentiation

  • R. G. Whalen


Among those systems that molecular biologists have chosen to study terminal differentiation, the genesis of skeletal muscle cells provides many of the advantages required to facilitate experimentation. Mononucleate cells can be grown in cell culture, and the dynamic process of cell fusion followed microscopically. The fusion of these mononucleate cells into multinucleate structures known as myotubes provides a dramatic visual indication that terminal differentiation is taking place (1). The fact that this process takes place in cell culture, allows the experimenter to intervene to modify culture conditions and thus attempt to modify the processes of myogenesis. This is crucial to the dissection of the relations between cell proliferation and cell differentiation. These two phenomena are mutually exclusive in the case of skeletal muscle cells and their myogenic precursors, the myoblasts.


Fibroblast Growth Factor Myosin Heavy Chain Myosin Light Chain Contractile Protein Myogenic Cell 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. G. Whalen
    • 1
  1. 1.Département de Biologie MoléculaireInstitut PasteurParisFrance

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