Proteins Affected by Chromosome 21 and Ageing In Vitro

  • M. L. Van Keuren
  • C. R. Merril
  • D. Goldman


An extra copy of chromosome 21 is the cause of the disorder known as Down syndrome. The mechanisms underlying the pathogenesis of this syndrome are unknown. Some of the features of Down syndrome are mental retardation, a high incidence of cardiac defects and predisposition for development of acute myeloblasts and acute lymphocytic leukemia (1). Individuals with this disorder display features of premature ageing (2, 3); those who survive into their 30’s and 40’s express dementia, accompanied by neuropathological features identical to those found in Alzheimer’s disease (4–6).


Down Syndrome Late Passage Gene Dosage Effect Hybrid Cell Line Mouse Cell Line 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • M. L. Van Keuren
    • 1
  • C. R. Merril
    • 1
  • D. Goldman
    • 2
  1. 1.Laboratory of General and Comparative BiochemistryBethesdaUSA
  2. 2.Laboratory of Clinical ScienceNational Institute of Mental HealthBethesdaUSA

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