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Enzootic Bovine Leukosis and Bovine Leukemia Virus

  • G. Marbaix
  • R. Kettmann
  • J. Deschamps
  • D. Couez
  • M. Mammerickx
  • A. Burny

Abstract

Enzootic bovine leukosis (EBL) is a lymphoproliferative disease of cattle characterized by persistent lymphocytosis (too high number of lymphocytes) and (or) by the development of lymph nodes tumours (1). EBL is contagious among cattle and experimentally transmissible to cattle, sheep and some other animal species. It affects B lymphocytes and is induced by a virus called Bovine Leukemia Virus (BLV) (2).

Keywords

Integration Site Bovine Leukemia Virus Avian Leukosis Virus Bovine Leukemia Virus Infection Avian Sarcoma Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    BURNY, A., BRUCK, C., CHANTRENNE, H., CLEUTER, Y., DEKEGEL, D., GHYSDAEL, J., KETTMANN, R., LECLERCQ, M., LEUNEN, J., MAMMERICKX, M. and PORTETELLE, D. (1980). Bovine Leukemia virus: molecular biology and epidemiology. In: Viral Oncology (ed. G. Klein), p. 231, Raven Press, New York.Google Scholar
  2. 2).
    MUSCOPLAT, C.C., JOHNSON, D.W., POMEROY, K.A., OLSON, J.M., LARSON, V.L., STEVENS, J.B., and SORENSEN, D.K. (1974). Lymphocyte surface immunoglobin: Frequency in normal and lymphocytotic cattle. Am. J. Vet. Res., 35, 593.Google Scholar
  3. 3).
    KETTMANN, R., PORTETELLE, D., MAMMERICKX, M., CLEUTER, Y., DEKEGEL, D., GALOUX, M., GHYSDAEL, J., BURNY, A. and CHANTRENNE, H. (1976). Bovine Leukemia virus: an exogenous RNA oncogenic virus. Proc. Natl. Acad. Sci. USA, 73, 1014.PubMedCrossRefGoogle Scholar
  4. 4).
    VAN DER MAATEN, M.J. and MILLER, J.M. (1976). Replication of bovine leukemia virus in monolayer cell cultures. Bibl. Haematol., 43, 360.Google Scholar
  5. 5).
    GHYSDAEL, J., KETTMANN, R. and BURNY, A. (1979). Translation of BLV virion RNAs in heterologous protein synthesizing systems. J. Virology, 29, 1087.PubMedGoogle Scholar
  6. 6).
    HAYWARD, W.S. and NEEL, B.C. (1981). Retroviral gene expression. In: Current Topics in Microbiology and Immunology, 91, 217, Springer-Verlag, Berlin.CrossRefGoogle Scholar
  7. 7).
    STEHELIN, D., VARMUS, H.E., BISHOP, J.M. and VOGT, P.K. (1976). DNA related to transforming gene(s) of avian sarcoma virus is present in normal avian DNA. Nature, 260, 170.PubMedCrossRefGoogle Scholar
  8. 8).
    HAYWARD, W.S., NEEL, B.C. and ASTRIN, S.M. (1981). Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature, 290, 475.PubMedCrossRefGoogle Scholar
  9. 9).
    PAYNE, G.S., COURTNEIDGE, S.A., CRITTENDEN, L.B., FADLY, A.M., BISHOP, J.M. and VARMUS, H.E. (1981). Analysis of Avian Leukosis Virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumour state. Cell, 23, 311.PubMedCrossRefGoogle Scholar
  10. 10).
    BEX, F., BRUCK, C., MAMMERICKX, M., PORTETELLE, D., GHYSDAEL, J., CLEUTER, Y., LECLERCQ, M., DEKEGEL, D. and BURNY, A. (1979). Humoral antibody response to Bovine Leukemia Virus infection in cattle and sheep. Cancer Research, 39, 1118.PubMedGoogle Scholar
  11. 11).
    MAMMERICKX, M., PORTETELLE, D., BURNY, A. and LEUNEN, J. (1980). Detection by immunodifusion- and radioimmunoassay-tests of antibodies to bovine leukemia virus antigens in sera of experimentally infected sheep and cattle. Zentralbl. Veterinaermed. Reihe B, 27, 291.Google Scholar
  12. 12).
    PORTETELLE, D., BRUCK, C., MAMMERICKX, M. and BURNY, A. (1980). In animals infected by Bovine Leukemia Virus, antibodies to envelope glycoprotein gp51 are directed against the carbohydrate moiety. Virology, 105, 223.PubMedCrossRefGoogle Scholar
  13. 13).
    BRUCK, C., PORTETELLE, D., BURNY, A. and ZAVADA, J. (1982). Topographical analysis of monoclonal antibodies of BLV-gp51 epitopes involved in viral functions. Virology, in press.Google Scholar
  14. 14).
    BURNY, A., BEX, F., CHANTRENNE, H., CLEUTER, Y., DEKEGEL, D., GHYSDAEL, J., KETTMANN, R., LECLERCQ, M., LEUNEN, J., MAMMERICKX, M. and PORTETELLE, D. (1978). Bovine Leukemia Virus involvement in enzootic bovine leukosis. Adv. Cancer Res., 28, 251.PubMedCrossRefGoogle Scholar
  15. 15).
    FERRER, J.G. (1980). Bovine Lymphosarcoma. In: Advances in Veterinary Science and Comparative Medicine, 24, 1, Academic Press, New York.Google Scholar
  16. 16).
    COFFIN, J.M., VARMUS, H.E., BISHOP, J.M., ESSEX, M., HARDY, W.D., MARTIN, G.S., ROSENBERG, N.E., SCOLNIK, E.M., WEINBERG, R.A. and VOGT, P.K. (1981). Proposal for naming host cell-derived inserts in retrovirus genomes. J. Virol., 40, 953.PubMedGoogle Scholar
  17. 17).
    DESCHAMPS, J., KETTMANN, R. and BURNY, A. (1981). Experiments with cloned complete tumour-derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species. J. Virol., 40, 605.PubMedGoogle Scholar
  18. 18).
    KETTMANN, R., CLEUTER, Y., MAMMERICKX, M., MEUNIER-ROTIVAL, M., BERNARDI, G., BURNY, A. and CHANTRENNE, H. (1980). Genomic integration of bovine leukemia provirus: comparison of persistent lymphocytosis with lymph node tumour form of enzootic bovine leukosis. Proc. Natl. Acad. Sci. USA, 77, 2577.PubMedCrossRefGoogle Scholar
  19. 19).
    KETTMANN, R., DESCHAMPS, J., CLEUTER, Y., COUEZ, D., BURNY, A. and MARBAIX, G. (1982). Leukemogenesis by bovine leukemia virus: proviral DNA integration and lack of RNA expression of viral long terminal repeat and 3’ proximate cellular sequences. Proc. Natl. Acad. Sci. USA, 79, 2465.PubMedCrossRefGoogle Scholar
  20. 20).
    KETTMANN, R., MARBAIX, G., CLEUTER, Y., PERTETELLE, D., MAMMERICKX, M. and BURNY, A. (1980). Genomic integration of bovine leukemia provirus and lack of viral RNA expression in the target cells of cattle with different responses to BLV infection. Leukemia Research, 4, 509.PubMedCrossRefGoogle Scholar
  21. 21).
    DUESBERG, P.H. (1979). Transforming genes of retroviruses. Cold Spring Harbor Symp. Quant. Biol., 44, 13.CrossRefGoogle Scholar
  22. 22).
    COLLETT, M.S., BRUGGE, J.S. and ERIKSON, R.L. (1978). Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product. Cell, 16, 1363.CrossRefGoogle Scholar
  23. 23).
    OPPERMANN, H., LEVINSON, A.D., VARMUS, H.E., LEVINTOW, L. and BISHOP, J.M. (1979). Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc. Natl. Acad. Sci. USA, 76, 1804.PubMedCrossRefGoogle Scholar
  24. 24).
    NEEL, B.G., HAYWARD, U.S., ROBINSON, H.L., FANG, J. and ASTRIN, S.M. (1981). Avian leukosis virus-induced tumours have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion. Cell, 23, 323.PubMedCrossRefGoogle Scholar
  25. 25).
    EVA, A., ROBBINS, K.C., ANDERSEN, P.R., SRINIVASAN, A., TRONICK, S.R., REDDY, E.P., ELLMORE, N.W., GALEN, A.T., LAUTENBERGER, J.A., PAPAS, T.S., WESTIN, E.H., WONG-STAAL, F., GALLO, R.C., and AARONSON, S.A. (1982). Cellular genes analogous to retroviral one genes are transcriped in human tumour cells. Nature, 295, 116.PubMedCrossRefGoogle Scholar
  26. 26).
    WESTIN, E.H., WONG-STAAL, F., GELMANN, E., DALLA FAVERA, R., PAPAS, T.S., LAUTENBERGER, J.A., EVA, A., REDDY, E.P., TRONICK, S.R., AARONSON, S.A. and GALLO, R.C. (1982). Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc. Natl. Acad. Sci. USA, 79, 2490.PubMedCrossRefGoogle Scholar
  27. 27).
    KETTMANN, R., WESTIN, E.H., MARBAIX, G., DESCHAMPS, J., WONG-STAAL, F., GALLO, R.C. and BURNY, A. (1983). Lack of expression of cellular homologues of retroviral onc genes in bovine tumours. In: Modern Trends in Human Leukemia V (ed. R. Neth), Haematolo-by and Blood Transfusion, Springer-Verlag, Berlin, in pressGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • G. Marbaix
    • 1
  • R. Kettmann
    • 1
    • 2
  • J. Deschamps
    • 1
  • D. Couez
    • 1
  • M. Mammerickx
    • 3
  • A. Burny
    • 1
    • 2
  1. 1.Department of Molecular BiologyUniversity of Brussels (ULB)Rhode-Saint-GenèseBelgium
  2. 2.Faculty of AgronomyGemblouxBelgium
  3. 3.National Veterinary InstituteUccleBelgium

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