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Calcitonin as an Anorectic Agent

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Psychoneuroendocrine Dysfunction

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Abstract

Calcitonin is a peptide hormone secreted by the C cells of the thyroid gland. Its primary physiological effect is to decrease plasma calcium and phosphorus concentrations. This action of calcitonin is particularly pronounced whenever plasma calcium becomes elevated (cf. Anast and Conaway, 1972; Copp et al., 1962; Copp, 1969; Hirsch et al., 1963; Munson and Gray, 1970). Calcitonin was discovered in 1962, after Copp and his colleagues (1962) found that perfusion of the thyroid-parathyroid complex with hypercalcemic solutions caused a lowering of plasma calcium concentrations. These results could not be explained in terms of decreased secretion of parathyroid hormone, which increases plasma calcium. Thus, it eventually became established that the thyroid secretes calcitonin, a hormone that decreases plasma calcium (Anast and Conaway, 1972; Copp, 1969; Talmage et al., 1980).

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References

  • Allan, W., and Tepperman, H. M., 1969, Stimulation of insulin secretion in the rat by glucagon, secretin, and pancreozymin: Effect of aminophylline, Life Sci. 8:307.

    Article  PubMed  CAS  Google Scholar 

  • Anast, C. S., and Conaway, H. H., 1972, Calcitonin, Clin. Orthop. Relax. Res. 84:207.

    Article  CAS  Google Scholar 

  • Ardaillou, R., 1975, Kidney and calcitonin, Nephron 15:250.

    Article  PubMed  CAS  Google Scholar 

  • Arnaud, C. D., and Tenenhouse, A., 1970, Parathyroid hormone, in: International Encyclopedia of Pharmacology and Therapeutics, Section 51, Vol. 1, Parathyroid Hormone, Thyrocalci-tonin, and Related Drugs (H. Rasmussen, ed.), pp. 197–235, Pergamon Press, Elmsford, N.Y.

    Google Scholar 

  • Avioli, L. V., Birge, S. J., Scott, S., and Shieber, W., 1969, Role of the thyroid gland during glucagon-induced hypocalcemia in the dog, Am. J. Physiol. 216:939.

    PubMed  CAS  Google Scholar 

  • Barker, L. M., Smith, J. C., and Suarez, E. M., 1977, “Sickness” and the backward conditioning of taste aversions, in: Learning Mechanisms in Food Selection (L. M. Barker, M. R. Best, and M. Doonjan, eds.), pp. 533–553, Baylor University Press, Waco, Tex.

    Google Scholar 

  • Becker, H. D., Konturek, S. J., Reeder, D. D., and Thompson, J. C., 1973, Effect of calcium and calcitonin on gastrin and gastric secretion in cats, Am. J. Physiol. 225:277.

    PubMed  CAS  Google Scholar 

  • Becker, K. L., Snider, R. H., Moore, C. F., Monoghan, K. G., and Silva, O., 1979, Calcitonin in extrathyroidal tissues of man, Acta Endocrinologica 92:746.

    PubMed  CAS  Google Scholar 

  • Becker, K. L., Silva, O. L., Post, R. M., Ballenger, J. C., Carmen, J. S., Snider, R. H., and Moore, C. F., 1980, Immunoreactive calcitonin in cerebrospinal fluid of man, Brain Res. 194:598.

    Article  PubMed  CAS  Google Scholar 

  • Bell, N. H., 1970, Effects of glucagon, dibutyryl cyclic 3’,5’-adenosine monophosphate, and theophylline on calcitonin secretion in vitro, J. Clin. Invest, 49:1368.

    Article  PubMed  CAS  Google Scholar 

  • Bennett, H. P. J., and McMartin, C., 1979, Peptide hormones and their analogues: Distribution, clearance from the circulation, and inactivation in vivo, Pharmacol. Rev. 30:247.

    Google Scholar 

  • Berger, B. D., 1972, Conditioning of food aversions by injections of psychoactive drugs, J. Comp. Physiol. Psychol. 81:21.

    Article  PubMed  CAS  Google Scholar 

  • Berger, M., Muller, W. A., and Renold, A. E., 1978, Relationship of obesity to diabetes: Some facts, many questions, in: Advances in Modern Nutrition, Vol. 2, Diabetes, Obesity, and Vascular Disease (H. M. Katzen and R. J. Mahler, eds.), pp. 211–228, Wiley, New York.

    Google Scholar 

  • Bieberdorf, F. A., Gray, T. K., Walsh, J. H., and Fordtran, J. S., 1974, Effect of calcitonin on meal-stimulated gastric acid secretion and serum gastrin concentration, Gastroenterology 66:343.

    PubMed  CAS  Google Scholar 

  • Bradbury, M., 1979, The Concept of a Blood-Brain Barrier, Wiley, New York.

    Google Scholar 

  • Braga, P., Ferri, S., Santagostino, A., Olgiati, V. R., and Pecile, A., 1978, Lack of opiate receptor nvolvement in centrally induced calcitonin analgesia, Life Sci. 22:971.

    Article  PubMed  CAS  Google Scholar 

  • Bryson, G., and Bischoff, F., 1980, Long-term estrogenization in mammals. III. Vasopressin and alcitonin in the regulation of water intake in estrogenized Marsh mice, Res. Commun. Chem. Pathol. Pharmacol. 29:499.

    PubMed  CAS  Google Scholar 

  • Care, A. D., Bates, R. F., and Gitelman, H. J., 1970, A possible role for the adenyl cyclase system in calcitonin release, J. Endocrinol. 48:1.

    Article  PubMed  CAS  Google Scholar 

  • Care, A. D., Bruce, J. B., Boelkins, J., Kenny, A. D., Conaway, H., and Anast, C. S., 1971, Role of pancreozymin-cholecystokinin and structurally related compounds as calcitonin secretogogues, Endocrinology 89:262.

    Article  PubMed  CAS  Google Scholar 

  • Carey, R. J., 1973, Long-term aversion to a saccharin solution induced by repeated amphetamine injections, Pharmacol. Biochem. Behav. 1:265.

    Article  PubMed  CAS  Google Scholar 

  • Carman, J. S., and Wyatt, R. J., 1977, Reduction of serum-prolactin after subcutaneous salmon calcitonin, Lancet 1:1267.

    Article  PubMed  CAS  Google Scholar 

  • Carman, J. S., and Wyatt, R. J., 1979a, Use of calcitonin in psychotic agitation or mania, Arch. Gen. Psychiatry 36:72.

    Article  PubMed  CAS  Google Scholar 

  • Carman, J. S., and Wyatt, R. J., 1979b, Calcium: Bivalent cation in the bivalent psychoses, Bio. Psychiatry 14:295.

    CAS  Google Scholar 

  • Clark, N. B., and Wideman, R. F., Jr., 1980, Calcitonin stimulation of urine flow and sodium excretion in the starling, Am. J. Physiol. 238:406.

    Google Scholar 

  • Clifton-Bligh, P., Robinson, B., Poon, T., and Posen, S., 1980 Calcitonin and the kidney, Prog. Biochem. Pharmacol. 17:204.

    PubMed  CAS  Google Scholar 

  • Cooper, C. W., Schwesinger, W. H., Mahgoub, A. M., and Ontijes, D. A., 1971, Thyrocalcitonin: Stimulation of secretion by pentagastrin, Science 172:1238.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, C. W., Obie, J. F., Toverud, S. U., and Munson, P. L., 1977, Elevated serum calcitonin and serum calcium during suckling in the baby rat, Endocrinology 101:1657.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, C. W., Bolman, R. M., III, Linehan, W. M., and Wells, S. A., Jr., 1978, Interrelationships between calcium, calcémie hormones and gastrointestinal hormones, Recent Prog. Horm. Res. 34:259.

    PubMed  CAS  Google Scholar 

  • Cooper, C. W., Peng, T. C., Obie, J. F., and Garner, S. C., 1980a, Calcitonin-like immunoreactivity in rat and human pituitary glands: Histochemical, in vitro and in vivo studies, Endocrinology 107:98.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, C. W., Obie, J. F., Margules, D. L., Flynn, J. J., and Walker, J., 1980b, Differences in the ability of calcitonins to inhibit food consumption in the rat, in: Abstracts of the 2nd Annual Meeting of the American Society for Bone and Mineral Research, p. 7A.

    Google Scholar 

  • Copp, D. H., 1969, Endocrine control of calcium homeostasis, J. Endocrinol. 43:137.

    Article  PubMed  CAS  Google Scholar 

  • Copp, D. H., Cameron, E. C., Cheney, B. A., Davidson, A. G., and Henze, K. G., 1962, Evidence for calcitonin—A new hormone from the parathyroid that lowers blood calcium, Endocrinology 70:638.

    Article  PubMed  CAS  Google Scholar 

  • Corcoran, M. E., Bolotow, I., Amit, Z., and McCaughran, J. A., 1974, Conditioned taste aversions produced by active and inactive cannabinoids, Pharmacol. Biochem. Behav. 2:725.

    Article  PubMed  CAS  Google Scholar 

  • Deftos, L. J., Burton, D., Bone, H. G., Catherwood, B. D., Parthemore, J. G., Moore, R. Y., Minick, S., and Guillemin, R., 1978, Immunoreactive calcitonin in the intermediate lobe of the pituitary gland, Life Sci. 23:743.

    Article  PubMed  CAS  Google Scholar 

  • Deftos, L. J., Burton, D. W., Watkins, W. B., and Catherwood, B. D., 1980, Immunohistological studies of ariodactyl and teleost pituitaries with antisera to calcitonin, Gen. Comp. Endocrinol. 42:9.

    Article  PubMed  CAS  Google Scholar 

  • Deutsch, J. A., and Hardy, W. T., 1977, Cholecystokinin produces bait shyness in rats, Nature (London) 266:196.

    Article  CAS  Google Scholar 

  • Domjan, M., and Gregg, B., 1977, Long-delay backward taste-aversion conditioning with lithium, Physiol. Behav. 18:59.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, R. S., and Smith, W. C., 1978, Chlordiazepoxide-fluoxetine interactions on food intake in free-feeding rats, Pharmacol. Biochem. Behav. 8:749.

    Article  PubMed  CAS  Google Scholar 

  • Findlay, D. M., deLuise, M., Michelangeli, V. P., Ellison, M., and Martin, T. J., 1980, Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line, Cancer Res. 40:1311.

    PubMed  CAS  Google Scholar 

  • Fischer, J. A., Sagar, S. M., and Martin, J. B., 1981, Characterization and regional distribution of calcitonin binding sites in the rat brain, Life Sci. 29:663.

    Article  PubMed  CAS  Google Scholar 

  • Forslund, K., Slanina, P., Stridsberg, M., and Appelgren, L. E., 1980, Whole body autoradiography of 3H- and 125I-labelled calcitonin in young rats, Acta Pharmacol. Toxicol. 46:398.

    Article  CAS  Google Scholar 

  • Freed, W. J., Perlow, M. J., and Wyatt, R. J., 1979, Calcitonin: Inhibitory effect on eating in rats, Science 206:850.

    Article  PubMed  CAS  Google Scholar 

  • Freed, W. J., Bing, L. A., and Wyatt, R. J., 1981, Calcitonin: Aversive effects in rats? Science 211:733.

    Article  Google Scholar 

  • Garcia, J., Hankins, W. G., and Rusiniak, K. W., 1974, Behavioral regulation of the milieu interne in man and rat: Food preferences set by delayed visceral effects facilitate memory research and predator control, Science 185:824.

    Article  PubMed  CAS  Google Scholar 

  • Garel, J. M., and Besnard, P., 1979, Milk factors controlling the plasma calcitonin level in the newborn rat, Endocrinology 104:1617.

    Article  PubMed  CAS  Google Scholar 

  • Garel, J. M., and Jullienne, A., 1977, Plasma calcitonin levels in pregnant and newborn rats, J. Endocrinol. 75:373.

    Article  CAS  Google Scholar 

  • Goltzman, D., 1980, Examination of interspecies differences in renal and skeletal receptor binding and adenylate cyclase stimulation with human calcitonin, Endocrinology 106:510.

    Article  PubMed  CAS  Google Scholar 

  • Goudie, A. J., and Dickins, D. W., 1978, Nitrous oxide-induced conditioned taste aversions in rats: The role of duration of drug exposure and its relation to the taste aversion-self-administration “paradox,” Pharmacol. Biochem. Behav. 9:587.

    Article  PubMed  CAS  Google Scholar 

  • Grote, F. W., and Brown, R. T., 1971, Conditioned taste aversions: Two-stimulus tests are more sensitive than one-stimulus tests, Behav. Res. Methods Instrum. 3:311.

    Article  Google Scholar 

  • Grubb, S. A., Decker, S. A., Taft, T. N., and Talmage, R. V., 1979, Effect of long-term thyroidectomy on post-prandial plasma calcium changes in man, J. Endocrinol. Invest. 2:75.

    PubMed  CAS  Google Scholar 

  • Habener, J. F., Singer, F. R., Deftos, L. J., Neer, R. J., and Potts, J. T., Jr., 1971, Explanation for unusual potency of salmon calcitonin, Nature New Biol. 232:91.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., Jr., Birge, S. J., and Avioli, L. V., 1970, Effects of prolonged thyrocalcitonin administration on Paget’s disease of bone, N. Engl. J. Med. 283:549.

    Article  PubMed  Google Scholar 

  • Hesch, R. D., Hiifner, M., Hausenhager, B., and Creutzfield, W., 1971, Inhibition of gastric secretion by calcitonin in man, Horm. Metab. Res. 3:140.

    Article  PubMed  CAS  Google Scholar 

  • Hirsch, P. F., 1967, Thyrocalcitonin inhibition of bone resorption induced by parathyroid extract in thryoparathyroidectomized rats, Endocrinology 80:539.

    Article  PubMed  CAS  Google Scholar 

  • Hirsch, P. F., Gauthier, G. F., and Munson, P. L., 1963, Thyroid hypocalcemic principle and recurrent laryngeal nerve injury as factors affecting the response to parathyroidectomy in rats, Endocrinology 73:244.

    Article  PubMed  CAS  Google Scholar 

  • Hoebel, B. G., 1977, Pharmacologic control of feeding, Annu. Rev. Pharmacol. Toxicol. 17: 605.

    Article  PubMed  CAS  Google Scholar 

  • Holtrop, M. E., Raisz, L. G., and Simmons, H. A., 1974, The effects of parathyroid hormone, colchicine, and calcitonin on the ultrastructure and the activity of osteoclasts in organ culture, J. Cell Biol. 60:346.

    Article  PubMed  CAS  Google Scholar 

  • Hsiao, S., and Pertsulakes, W., 1970, Feeding-drinking interaction: Food rationing and intake of liquids varying in taste, caloric and osmotic properties, Physiol. Behav. 5:1495.

    Article  PubMed  CAS  Google Scholar 

  • Huwyler, R., Born, W., Ohnhaus, E. E., and Fischer, J. A., 1979, Plamsa kinetics and urinary excretion of exogenous human and salmon calcitonin in man, Am. J. Physiol. 236:E15.

    PubMed  CAS  Google Scholar 

  • Ionescu, E., and Buresová, O., 1977, Failure to elicit conditioned taste aversion by severe poisoning, Pharmacol. Biochem. Behav. 6:251.

    Article  PubMed  CAS  Google Scholar 

  • Isaac, R., Merceron, R., Caillens, G., Raymond, J. P., and Ardaillou, R., 1980, Effects of calcitonin on basal and thyrotropin-releasing hormone-stimulated prolactin secretion in man, J. Clin. Endocrinol. Metab. 50:1011.

    Article  PubMed  CAS  Google Scholar 

  • Iwasaki, Y., Chihara, K., Iwasaki, J., Abe, H., and Fujita, T., 1979, Effect of calcitonin on prolactin release in rats, Life Sci. 25:1243.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, H. L., 1964, The interaction of hunger and thirst: Experimental separation of osmotic and oral-gastric factors in the regulation of caloric intake, in: Thirst First International Symposium on Thirst in the Regulation of Body Water (M. J. Wagner, ed.), pp. 117–137, Pergamon Press, Elmsford, N.Y.

    Google Scholar 

  • Koida, M., Nakamuta, H., Furukawa, S., and Orlowski, R. C., 1980, Abundance and location of 125I-salmon calcitonin binding site in rat brain, Jpn. J. Pharmacol. 30:575.

    Article  PubMed  CAS  Google Scholar 

  • Levine, A. S., and Morley, J. E., 1981, Reduction of feeding in rats by calcitonin, Brian Res. 22:187.

    Article  Google Scholar 

  • Lorenz, D. N., Kreielsheimer, G., and Smith, G. P., 1979, Effect of cholecystokinin, gastrin, secretin, and GIP on sham feeding in the rat, Physiol. Behav. 23:1065.

    Article  PubMed  CAS  Google Scholar 

  • Maddison, S., 1977, Intraperitoneal and intracranial cholecystokinin depress operant responding for food, Physiol. Behav. 19:819.

    Article  PubMed  CAS  Google Scholar 

  • Manaker, S., Ackerman, S. H., and Weiner, H., 1979, Intracerebroventricular pentagastrin fails to affect feeding and acid secretion in the rat, Physiol. Behav. 23:395.

    Article  PubMed  CAS  Google Scholar 

  • Margules, D. L., Flynn, J. J., Walker, J., and Cooper, C. W., 1979, Elevation of calcitonin immunoreactivity in the pituitary and thyroid glands of genetically obese rats (fa/fa)Brain Res. Bull. 4:589.

    Article  PubMed  CAS  Google Scholar 

  • Martin, C. R., 1976, Textbook of Endocrine Physiology, Oxford University Press, London.

    Google Scholar 

  • Martin, J. R., and Novin, D., 1977, Decreased feeding in rats following hepatic-portal infusion of glucagon, Physiol. Behav. 19:461.

    Article  PubMed  CAS  Google Scholar 

  • Marx, S. J., Woodard, C. J., and Aurbach, G. D., 1972, Calcitonin receptors of kidney and bone, Science 178:999.

    Article  PubMed  CAS  Google Scholar 

  • Marx, S. J., Aurbach, G. D., Gavin, J. R., III, and Buell, D. W., 1974, Calcitonin receptors on cultured human lymphocytes, J. Biol. Chem. 249:6812.

    PubMed  CAS  Google Scholar 

  • Mattheij, J. A. M., Sterrenberg, L., and Swarts, H. J., 1980, Current concepts. III. Prolactin and calcium metabolism in the rat, Life Sci. 27:2031.

    Article  PubMed  CAS  Google Scholar 

  • Metz, S. A., Deftos, L. J., Baylink, D. J., and Robertson, R. P., 1978, Neuroendocrine modulation of calcitonin and parathyroid hormone in man, J. Clin. Endocrinol. Metab. 47:151.

    Article  PubMed  CAS  Google Scholar 

  • Morley, J. E., and Levine, A. S., 1981, Intraventricular calcitonin inhibits gastric acid secretion, Science 214:671.

    Article  PubMed  CAS  Google Scholar 

  • Morley, J. E., Levine, A. S., and Kneip, J., 1981, Muscimol induced feeding: A model to study the hypothalamic regulation of appetite, Life Sci. 29:1213.

    Article  PubMed  CAS  Google Scholar 

  • Munson, P. L., and Gray, T. K., 1970, Function of thyrocalcitonin in normal physiology, Fed. Proc. 29:1206.

    PubMed  CAS  Google Scholar 

  • Myers, R. D., and Bender, S. A., 1973, Action of excess calcium ions in the brain on motivated feeding in the rat: Attenuation by pharmacological antagonists, Pharmacol. Biochem. Behav. 1:569.

    Article  PubMed  CAS  Google Scholar 

  • Myers, R. D., Bender, S. A., Krstíc, M. K., and Brophy, P. D., 1972, Feeding produced in the satiated rat by elevating the concentration of calcium in the brain, Science 176:1124.

    Article  PubMed  CAS  Google Scholar 

  • Myers, R. D., Melchior, C. L., and Gisolfi, C. V., 1976, Feeding and body temperature in the rat: Diencephalic localization of changes produced by excess calcium ions, Brain Res. Bull. 1:33.

    Article  PubMed  CAS  Google Scholar 

  • Nachman, M., and Hartley, P. L., 1975, Role of illness in producing learned taste aversions in rats: A comparison of several rodenticides, J. Comp. Physiol. Psychol. 89:1010.

    Article  PubMed  CAS  Google Scholar 

  • Nakhla, A. M., 1979, Calcitonin: Effect on protein synthesis in different rat tissues, Experientia 35:1525.

    Article  PubMed  CAS  Google Scholar 

  • Nemeroff, C. B., Osbahr, A. J., III, Bissette, G., Jahnke, G., Lipton, M. A., and Prange, A. J., Jr., 1978, Cholecystokinin inhibits tail pinch-induced eating in rats, Science 200:793.

    Article  PubMed  CAS  Google Scholar 

  • Nobel, E. P., Wurtman, R. J., and Axelrod, J., 1967, A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain, Life Sci. 6:281.

    Article  Google Scholar 

  • Olgiati, U. R., Guidobono, F., Luisetto, G., Hetti, C., Bianchi, C., and Pecile, A., 1981, Calcitonin inhibition of physiological and stimulated prolactin secretion in rats, Life Sci. 29:585.

    Article  PubMed  CAS  Google Scholar 

  • Pahuja, D. N., and DeLuca, H. F., 1981, Stimulation of intestinal calcium transport and bone calcium mobilization by prolactin in vitamin D-deficient rats, Science 214:1038.

    Article  PubMed  CAS  Google Scholar 

  • Paillard, F., Ardaillou, R., Malendin, H., Fillastre, J.-P., and Prier, S., 1972, Renal effects of salmon calcitonin in man, J. Lab. Clin. Med. 80:200.

    PubMed  CAS  Google Scholar 

  • Pak, C. Y., Wills, M. R., Smith, G. W., III, and Bartter, F. C., 1968, Tretament with thyrocalcitonin of the hypercalcemia of parathyroid carcinoma, J. Clin. Endocrinol. 28:1657.

    Article  CAS  Google Scholar 

  • Parthemore, J. G., and Deftos, L. J., 1978, Calcitonin secretion in normal human subjects, J. Clin. Endocrinol. Metab. 47:184.

    Article  PubMed  CAS  Google Scholar 

  • Pavlinac, D. M., Lenhard, L. W., Parthemore, J. G., and Deftos, L. J., 1980, Immunoreactive calcitonin in human cerebrospinal fluid, J. Clin. Endocrinol. Metab. 50:717.

    Article  PubMed  CAS  Google Scholar 

  • Pecile, A., Ferri, S., Braga, P. C., and Olgiati, V. R., 1975, Effects of intracerebroventricular calcitonin in the conscious rabbit, Experientia 31:332.

    Article  PubMed  CAS  Google Scholar 

  • Perlow, M. J., Freed, W. J., Carman, J. S., and Wyatt, R. J., 1980, Calcitonin reduces feeding in man, monkey, and rat, Pharmacol. Biochem. Behav. 12:609.

    Article  PubMed  CAS  Google Scholar 

  • Queener, S. F., Fleming, J. W., and Bell, N. H., 1975, Solubilization of calcitonin-responsive renal cortical adenylate cyclase, J. Biol. Chem. 250:7586.

    PubMed  CAS  Google Scholar 

  • Rapaport, S. I., 1976, Blood-Brain Barrier in Physiology and Medicine, Raven Press, New York.

    Google Scholar 

  • Rasmussen, H., and Pechet, M., 1970, Calcitonin and thyrocalcitonin, in: International Encyclopedia of Pharmacology and Therapeutics, Section 51, Vol. 1, Parathyroid Hormone, Thyrocalcitonin, and Related Drugs (H. Rasmussen, ed.), pp. 237–260, Pergamon Press, Elmsford, N.Y.

    Google Scholar 

  • Reaven, G. M., and Olefsky, J. M., 1978, Role of insulin resistance in the pathogenesis of hyperglycemia, in: Advances in Modern Nutrition, Vol. 2, Diabetes, Obesity, and Vascular Disease (H. M. Katzen and R. J. Mahler, eds.), pp. 229–266, Wiley, New York.

    Google Scholar 

  • Rizzo, A. J., and Goltzman, D., 1981, Calcitonin receptors in the central nervous system of the rat, Endocrinology 108:1672.

    Article  PubMed  CAS  Google Scholar 

  • Roos, B. A., and Deftos, L. J., 1976, Calcitonin secretion in vitro. II. Regulatory effects of enteric mammalian polypeptide hormones on trout C-cell cultures, Endocrinology 98:1284.

    Article  PubMed  CAS  Google Scholar 

  • Roos, B. A., Bergeron, G., Guggenheim, K., and Deftos, L. J., 1977, Maturational increase in plasma calcitonin related to gastrointestinal function, Clin. Res. 25:398a.

    Google Scholar 

  • Rozin, P., 1967, Specific aversions as a component of specific hungers, J. Comp. Physiol. Psychol. 64:237.

    Article  PubMed  CAS  Google Scholar 

  • Satoh, M., Amano, H., Nakazawa, T., and Takagi, H., 1979, Inhibition by calcium of analgesia induced by intracisternal injection of porcine calcitonin in mice, Res. Commun. Chem. Pathol. Parmacol. 26:213.

    CAS  Google Scholar 

  • Seoane, J. R., and Baile, C.A., 1973a, Feeding behavior in sheep as related to the hypnotic activities of barbiturates injected into the third ventricle, Pharmacol. Biochem. Behav. 1:47.

    Article  PubMed  CAS  Google Scholar 

  • Seoane, J. R., and Baile, C.A., 1973b, Feeding elicited by injections of Ca+ + and Mg+ + into the third ventricle of sheep, Experientia 29:61.

    Article  PubMed  CAS  Google Scholar 

  • Seoane, J. R., McLaughlin, C.L., and Baile, C. A., 1975, Feeding following intrahypothalamic injections of calcium and magnesium ions in sheep, J. Dairy Sci. 58:349.

    Article  PubMed  CAS  Google Scholar 

  • Sethi, R., Kukreja, S. C., Bowser, E. N., Hareis, G. K., and Williams, G. A., 1981, Effects of secretin on parathyroid hormone and calcitonin secretion, J. Clin. Endocrinol. Metab. 53:153.

    Article  PubMed  CAS  Google Scholar 

  • Shai, F., Baker, R. K., and Wallach, S., 1971, The clinical and metabolic effects of porcine calcitonin on Paget’s disease of bone, J. Clin. Invest. 50:1927.

    Article  PubMed  CAS  Google Scholar 

  • Smith, G. P., and Gibbs, J., 1975, Cholecystokinin: A putative satiety signal, Pharmacol. Biochem. Behav. 3:135.

    PubMed  CAS  Google Scholar 

  • Smith, G. P., Gibbs, J., and Young, R. C., 1974, Cholecystokinin and intestinal satiety in the rat, Fed.Proc. 33:1146.

    PubMed  CAS  Google Scholar 

  • Swaminathan, R., Bates, R. F., Bloom, S. R., Ganguli, R. C., and Care, A. D., 1973, The relationship between food, gastro-intestinal hormones and calcitonin secretion, J. Endocrinol. 59:217.

    Article  PubMed  CAS  Google Scholar 

  • Talmage, R. V., Doppelt, S. H., and Cooper, C. W., 1975, Relationship of blood concentrations of calcium, phosphate, gastrin and calcitonin to the onset of feeding in the rat, Proc. Soc. Exp. Biol. Med. 149:855.

    PubMed  CAS  Google Scholar 

  • Talmage, R. V., Grubb, S. A., Norimatsu, H., and Vanderwiel, C. J., 1980, Evidence for an immportant physiological role for calcitonin, Proc. Natl. Acad. Sci. USA 77:609.

    Article  PubMed  CAS  Google Scholar 

  • Tashjian, A. H., Jr., and Warnock, D. R., 1967, Stability of the hypocalcemic activity of porcine thyrocalcitonin, Endocrinology 81:306.

    Article  PubMed  CAS  Google Scholar 

  • Tepperman, B. L., and Evered, M. D., 1980, Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats, Science 209:1142.

    Article  PubMed  CAS  Google Scholar 

  • Toszeghi, P., Tobler, I., and Borbély, A., 1978, Cerebral ventricular infusion of excess calcium in the rat: Effects on sleep states, behavior and cortical EEG, Eur. J. Pharmacol. 51:407.

    Article  PubMed  CAS  Google Scholar 

  • Vogel, J. R., and Nathan, B. A., 1975, Learned taste aversions induced by hypnotic drugs, Pharmacol. Biochem. Behav. 3:189.

    Article  PubMed  CAS  Google Scholar 

  • Watkins, W. B., Moore, R. Y., Burton, D., Bone, H. G., III, Catherwood, B. D., and Deftos, L. J., 1980, Distribution of immunoreactive calcitonin in the rat pituitary gland, Endocrinology 106:1966.

    Article  PubMed  CAS  Google Scholar 

  • Wise, R. A., Yokel, R. A., and deWit, H., 1976, Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats, Science 191:1273.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, M., Kumagai, F., Tachikawa, S., and Maeno, H., 1979, Lack of effect of levallorphan on analgesia induced by intraventricular application of porcine calcitonin in mice, Eur. J. Pharmacol. 55:211.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, M., Tachikawa, S., and Maeno, H., 1981, Evoked potential studies of porcine calcitonin in rabbits, Neuropharmacology 20:83.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, Saint Elizabeths Hospital, National Institute of Mental Health, Washington, D.C., 20032, USA

    William J. Freed, Lloyd A. Bing & Richard Jed Wyatt

  2. Department of Psychiatry, Johns Hopkins University Medical Center, Baltimore, Maryland, 21218, USA

    Arnold E. Andersen

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  1. William J. Freed
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  2. Lloyd A. Bing
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  3. Arnold E. Andersen
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  4. Richard Jed Wyatt
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Editors and Affiliations

  1. Ensor Foundation Research Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) (Director, Research Professor)

  2. Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) & Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Research Professor) &  (Director, Professor and Chairman)

  3. William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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© 1984 Plenum Publishing Corporation

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Freed, W.J., Bing, L.A., Andersen, A.E., Wyatt, R.J. (1984). Calcitonin as an Anorectic Agent. In: Shah, N.S., Donald, A.G. (eds) Psychoneuroendocrine Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4529-9_5

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  • DOI: https://doi.org/10.1007/978-1-4684-4529-9_5

  • Publisher Name: Springer, Boston, MA

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