Calcitonin as an Anorectic Agent

  • William J. Freed
  • Lloyd A. Bing
  • Arnold E. Andersen
  • Richard Jed Wyatt


Calcitonin is a peptide hormone secreted by the C cells of the thyroid gland. Its primary physiological effect is to decrease plasma calcium and phosphorus concentrations. This action of calcitonin is particularly pronounced whenever plasma calcium becomes elevated (cf. Anast and Conaway, 1972; Copp et al., 1962; Copp, 1969; Hirsch et al., 1963; Munson and Gray, 1970). Calcitonin was discovered in 1962, after Copp and his colleagues (1962) found that perfusion of the thyroid-parathyroid complex with hypercalcemic solutions caused a lowering of plasma calcium concentrations. These results could not be explained in terms of decreased secretion of parathyroid hormone, which increases plasma calcium. Thus, it eventually became established that the thyroid secretes calcitonin, a hormone that decreases plasma calcium (Anast and Conaway, 1972; Copp, 1969; Talmage et al., 1980).


Anorexia Nervosa Gastric Acid Secretion Taste Aversion Conditioned Taste Aversion Salmon Calcitonin 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • William J. Freed
    • 1
  • Lloyd A. Bing
    • 1
  • Arnold E. Andersen
    • 2
  • Richard Jed Wyatt
    • 1
  1. 1.Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, Saint Elizabeths HospitalNational Institute of Mental HealthUSA
  2. 2.Department of PsychiatryJohns Hopkins University Medical CenterBaltimoreUSA

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