Effects of Long-Term Neuroleptic Treatment on Serum Levels of Prolactin, TSH, LH, and Norepinephrine and on α-Adrenergic and Dopaminergic Receptor Sensitivity

Relations to Tardive Dyskinesia
  • Dieter Naber
  • Franz Müller


Neuroendocrine effects of catecholamine receptor-blocking neuroleptic drugs have been investigated in numerous studies (Ackenheil, 1981; Brambilla et al., 1979a; Burt et al., 1977; Carlsson, 1978, Collu et al., 1977; Ettigi et al., 1976; Meltzer et al., 1978; Pandey et al., 1977; Sachar, 1978); in particular, the increase of serum prolactin (PRL) after acute neuroleptic treatment is well documented (Gruen et al., 1978; Langer et al., 1977; Rubin and Hays, 1980, Wode-Helgodt, et al., 1977). There are, however, only a few studies dealing with the neuroendocrine effects of chronic neuroleptic treatment. As both differ distinctly, inferring long-term effects from short-term effects is inappropriate (Ler-ner et al., 1977). Moreover, there are striking differences in the reactivity of the tuberoinfundibular, nigrostrial, mesolimbic, and mesocortical dopaminergic systems to long-term treatment with neuroleptics (Bowers and Rozitis, 1974; Julou et al., 1977).


Schizophrenic Patient Tardive Dyskinesia Drug Withdrawal Neuroleptic Drug Neuroleptic Treatment 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Dieter Naber
    • 1
  • Franz Müller
    • 1
  1. 1.Psychiatric Hospital of the University of MunichMunichGermany

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