Neuroendocrine Changes during the Course of Neuroleptic Treatment of Schizophrenic Patients

  • Norbert Nedopil
  • Johannes Weiss-Brummer
  • Eckart Rüther


The blockade of postsynaptic dopaminergic receptors is considered to be the most important biological factor in the action of neuroleptic drugs for the treatment of schizophrenia (Carlsson, 1978; Johnstone et al., 1978). A wide variety of indirect evidence (Crow et al., 1976; Van Kammen, 1979; Snyder, 1976; Meltzer and Stahl, 1976) and some direct evidence in postmortem brains of schizophrenic patients (Lee and Seeman, 1977) supported the dopamine hypothesis of schizophrenia, i.e., that the productive symptoms of schizophrenia are associated with a relative excess of dopaminergic activity in certain subcortical brain structures.


Schizophrenic Patient Growth Hormone Secretion Human Growth Hormone Growth Hormone Response Neuroleptic Drug 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Norbert Nedopil
    • 1
  • Johannes Weiss-Brummer
    • 1
  • Eckart Rüther
    • 1
  1. 1.Psychiatric Hospital of the University of MunichMunich 2Germany

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