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Hormonal Responses to D-Amphetamine in Schizophrenia

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Book cover Psychoneuroendocrine Dysfunction

Abstract

The effects of D-amphetamine in man and particularly in schizophrenic patients have been studied because of the hypothesized disturbance in the dopamine (DA) and norepinephrine (NE) systems in the illness. In this chapter, we incorporated several of our studies of the effects of D-amphetamine on hormonal secretion. We studied PRL, which is under tonic inhibitory control of DA (MacLeod and Lamberts, 1979; Clemens and Shaar, 1980; Meites, 1973), growth hormone (GH), which can be released by both NE (Massara and Camanni, 1972) and DA (Malas et al., 1983; Meltzer et al., 1979), and Cortisol, which is under partial control of NE (Sachar et al., 1981). Furthermore, we examined immunoreactive (i.r.) β-endorphin levels assuming that the euphoria that is experienced may be mediated by endorphin release as well as the hypothesized β-endorphin disturbance in schizophrenia (Berger et al., 1980; Davis et al., 1980; Bloom et al., 1976).

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Authors and Affiliations

  1. Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA

    Daniel P. Van Kammen & S. Charles Schulz

  2. University of Virginia Medical Center, Charlottesville, Virginia, 22908, USA

    Alan D. Rogol

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  1. Daniel P. Van Kammen
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  2. S. Charles Schulz
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  3. Alan D. Rogol
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Editors and Affiliations

  1. Ensor Foundation Research Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) (Director, Research Professor)

  2. Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) & Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Research Professor) &  (Director, Professor and Chairman)

  3. William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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© 1984 Plenum Publishing Corporation

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Van Kammen, D.P., Schulz, S.C., Rogol, A.D. (1984). Hormonal Responses to D-Amphetamine in Schizophrenia. In: Shah, N.S., Donald, A.G. (eds) Psychoneuroendocrine Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4529-9_31

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  • DOI: https://doi.org/10.1007/978-1-4684-4529-9_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4531-2

  • Online ISBN: 978-1-4684-4529-9

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