Neuroendocrine Studies in Schizophrenia
An alteration in the function of dopamine (DA) has been related to the pathophysiology of schizophrenic illness and has led to the so-called “dopamine hypothesis of schizophrenia.” Although there has been only indirect evidence to support this hypothesis (see Meltzer and Stahl, 1976), this has stimulated extensive clinical research for investigating the role of DA in schizophrenic illness. The initial research was directed either toward studying the levels of DA and its metabolites in urine, plasma, and CSF or examining the enzymes associated with the biosynthesis and metabolism of DA in schizophrenic patients. In particular, these studies attempted to elucidate the role of presynaptic dopaminergic mechanisms in schizophrenia. However, in recent years the role of postsynaptic mechanisms such as DA receptor response or DA receptor density has been studied in patients with schizophrenic illness. Such studies have been primarily stimulated by the observations that the potency of antipsychotic drugs is related to their ability to block DA receptors in the brain.
KeywordsSchizophrenic Patient Tardive Dyskinesia Growth Hormone Release Acute Schizophrenia Chronic Schizophrenic Patient
Unable to display preview. Download preview PDF.
- Ettigi, P., Nair, N. P. V., Lal, S., Cervantes, P., and Guyda, H., 1976, Effect of apomorphine on growth hormone and prolactin secretion in schizophrenic patients, with or without oral dyskinesia, withdrawn from chronic neuroleptic therapy, J. Neurol. Neurosurg. Psychiatry 39:870.PubMedCrossRefGoogle Scholar
- Garver, D. L., 1981, Patterns of illness in lithium responsive patients, Scientific Proceedings of the American Psychiatric Association.Google Scholar
- Pandey, G. N., Casper, R. C., Davis, J. M., Ali, S. I., and Garver, D. L., 1979, Elevated Growth Hormone Response in Schizophrenia: Syllabus and Scientific Proceedings, American Psychiatric Association, p. 345.Google Scholar
- Randrup, A., and Munkvard, I., 1970, Biochemical, anatomical and psychological investigations of stereotyped behavior induced by amphetamines, in: Amphetamines and Related Compounds (E. Costa and S. Garattini, eds.), pp. 695–713, Raven Press, New York.Google Scholar
- Seeman, P., 1981, Brain dopamine receptors, Pharmacol. Rev. 32:229.Google Scholar