A Study of Circadian Variation of Platelet Serotonin Uptake and Serum Cortisol in Patients with Major Depression

  • Jeffrey L. Rausch
  • Nandkumar S. Shah
  • Earl A. Burch
  • Alexander G. Donald
  • Ethan V. Munson


The blood platelet shares many characteristics in common with synaptosomes, and has been suggested as a model for central serotoninergic neuronal functioning (Murphy et al., 1970; Stahl, 1977). Serotonin (5HT) has been indirectly implicated in the pathophysiology of depression (van Praag and Korf, 1971) and, as such, the uptake of 5HT into the platelet assumes potential importance as a possible indicator of central 5HT uptake activity, as both platelets and synaptosomes share similar Michaelis constants (K m ) for 5HT uptake to the nearest order of magnitude (Stahl and Meltzer, 1978; Smith et al., 1978).


Serum Cortisol Blood Platelet Circadian Variation Serotonin Uptake Endogenous Depression 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Jeffrey L. Rausch
    • 1
    • 2
  • Nandkumar S. Shah
    • 3
  • Earl A. Burch
    • 4
  • Alexander G. Donald
    • 4
  • Ethan V. Munson
    • 2
  1. 1.Ensor Foundation Research LaboratoryWilliam S. Hall Psychiatric InstituteColumbiaUSA
  2. 2.Department of PsychiatryUniversity of California at San DiegoLa JollaUSA
  3. 3.Ensor Research FoundationUSA
  4. 4.William S. Hall Psychiatric Institute, and Department of Neuropsychiatry and Behavioral SciencesUniversity of South Carolina School of MedicineColumbiaUSA

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