The TRH Test in the Diagnosis of Affective Disorders and Schizophrenia

  • Mark S. Gold
  • A. Carter Pottash
  • Irl Extein


An impressive body of genetic (Winokur et al., 1969; Rosenthal and Kety, 1968), biological, phenomenological, and pharmacological response (Spitzer et al., 1978; Schou et al., 1954; Casey et al., 1960; Davis, 1975, 1976; Taylor et al., 1974; Pope and Lipinski, 1978) data support the concept of affective disorders and schizophrenia as distinct entities. These data further support the division of depressive disorders into primary “major depressive disorders” and secondary “minor” and “depressive spectrum” disorders, as well as the division of major depressions into unipolar and bipolar subtypes (Spitzer et al., 1978; Schiesser et al., 1979; Goodwin and Extein, 1979). The development of specific and effective pharmacotherapies for affective disorders and schizophrenia has underlined the need for accurate diagnosis of these disorders. One strategy for augmenting clinical diagnosis is to measure biological correlates that, in addition to elucidating the biological mechanisms of psychiatric disorders, may more clearly define homogeneous groups of psychiatric patients and guide the choice of pharmacotherapy.


Bipolar Depression Unipolar Depression Minor Depression Research Diagnostic Criterion Minor Depressive Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Mark S. Gold
    • 1
    • 2
  • A. Carter Pottash
    • 1
    • 2
  • Irl Extein
    • 3
  1. 1.Research Facilities, and Psychiatric Diagnostic Laboratories of AmericaFair Oaks HospitalSummitUSA
  2. 2.Department of PsychiatryYale UniversityNew HavenUSA
  3. 3.Falkirk HospitalCentral ValleyUSA

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