Vasopressin in Neuropsychiatric Disorders

  • J. J. Legros
  • Ioana Lancranjan


Increasing evidence has been accumulated in the past decade indicating that the neurohormones and/or neuropeptides synthesized by neurons located in the hypothalamus and in extrahypothalamic areas of the brain influence the brain functions, the “peptidergic” neurons being an integral part of the working of the mammalian CNS (Guillemin, 1977).


Schizophrenic Patient Diabetes Insipidus Neuropsychiatric Disorder Posttraumatic Amnesia Korsakoff Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adolfsson, R., Bucht, G., Lancranjan, I., Said, S., Seif, S., Svennerholm, L., and Winblad, B., 1983, Endocrine and metabolic effects of vasopressin in patients with multiinfarct dementia, in: Neuropeptide and Hormone Modulation of Brain Function and Homeostasis (J. M. Orday, J. R. Sladek, and B. Reisberg, eds.), Raven Press, New York, in press.Google Scholar
  2. Anderson, L. T., David, R., Bonnet, K., and Daneis, J., 1979, Passive avoidance learning in Leasch-Nyhan disease: Effect of l-desamino-8-arginine-vasopressin, Life Sci. 24:905.PubMedCrossRefGoogle Scholar
  3. Bargmann, W., and Scharrer, E., 1951, The site of origin of the hormones of the posterior pituitary, Am. Sci. 39:255.Google Scholar
  4. Barker, J. L., 1976, Peptides: Roles in neuronal excitability, Physiol. Rev. 56:435.PubMedGoogle Scholar
  5. Bentley, P. J., 1969, The effect of valinomycin on the toad bladder: Antagonism to vasopressin and aldosterone, J. Endocrinol. 45:287.PubMedCrossRefGoogle Scholar
  6. Berl, S., Puszkin, S., Nicklas, W. J., 1973, Actomyosin-like protein may function in the release of transmitter material at synaptic endings. Science 179:441.PubMedCrossRefGoogle Scholar
  7. Brambilla, F., and Penati, G., 1978, Schizophrenia: Endocrinological review, in: Perspectives in Endocrine Psychobiology (F. Brambilla, P. K. Bridges, E. Endroczi, and G. Heuser, eds.), pp. 309–421, Wiley, New York.Google Scholar
  8. Bucht, G., Adolfsson, R., Lancranjan, I., and Winblad, B., 1983, Vasopressin in multiinfarct dementia and other neuropsychiatric disorders, in: Neuropeptide and Hormone Modulation of Brain Function and Homeostasis (J. M. Ordy, J. R. Sladek, and B. Reisberg, eds.), Raven Press, New York, in press.Google Scholar
  9. Buijs, R. M., Swaab, D. F., Dogterom, J., and van Leeuwen, F. W., 1978, Intra- and extrahy-pothalamic vasopressin and oxytocin pathways in the rat, Cell Tissue Res. 186:423.PubMedCrossRefGoogle Scholar
  10. Burford, G. D., Jones, C. W., and Pickering, B. T., 1971, Tenative identification of a vasopressin-neurophysin and an oxytocin neurophysin in the rat, Biochem. J. 124:809.PubMedGoogle Scholar
  11. Chase, T. N., Durso, R., Fedio, P., and Tamminga, C. A., 1981, Vasopressin treatment of cognitive déficits in Alzheimer’s disease, in: Alzheimer’s Disease: A Report of Progress in Research (S. Corkin, K. L. Davis, J. H. Growdon, E. Usdin, and R. J. Wurtman, eds.), Raven Press, New York.Google Scholar
  12. Delwaide, P. J., Devoitille, J. M., and Ylieff, M., 1980, Acute effect of drugs upon memory of patients with senile dementia, Acta Psychiatr. Belg. 80:748.PubMedGoogle Scholar
  13. de Wied, D., 1965, The influence of the posterior and intermediate lobe of the pituitary and pituitary peptides on the maintenance of a conditioned avoidance response in rats, Int. J. Neuropharmacol. 4:157.CrossRefGoogle Scholar
  14. de Wied, D., Bohus, B., Gispen, W. H., van Ree, J. M., Urban, I., and van Wimersma Greidanus, T. B., 1977, Neurohypophyseal hormones and behavior, in: Neurohypophysis (A. M. Moses and L. Share, eds.) pp. 201–210, Karger, Basel.Google Scholar
  15. Dierickx, K., and Vandersande, F., 1977, Immunocytochemical localization of the vasopressinergic and the oxytocinergic nerves in the human hypothalamus, Cell Tissue Res. 184:15.PubMedCrossRefGoogle Scholar
  16. Dousa, T. P., Barnes, L. D., and Kim, J. K., 1977, The role of the cyclic AMP-dependent protein phosphorylations and microtubules in the cellular action of vasopressin in mammalian kidney, in: Neurohypophysis (A. M. Moses and L. Share, eds.), pp. 220–235, Karger, Basel.Google Scholar
  17. Drago, F., Rapisarda, V., Calandra, C., Filetti, S., and Scapagnini, U., 1981, A clinical evaluation of the effects of vasopressin on memory disorders, Acta Ther. 7:345.Google Scholar
  18. Ferris, S. H., and Reisber, B., 1981, Treating dementia with neuropeptides and piracetam, in: Alzheimer’s Disease: A Report of Progress in Research (S. Corkin, K. L. Davis, J. H. Growdon, E. Usdin, and R. J. Wurtman, eds.), Raven Press, New York.Google Scholar
  19. Forizs, L., 1952, The use of pitressin in the treatment of schizophrenia with deterioration, N.C. Med. J. 13:76.PubMedGoogle Scholar
  20. Gainer, H., Same, Y., and Brownstein, M. J., 1977, Neurophysin biosynthesis: Conversion of a putative precursor during axonal transport, Science 195:1354.PubMedCrossRefGoogle Scholar
  21. Gilot, P., Crabbe, J., and Legros, J. J., 1979, Bilan mnesique chez 5 sujets presentant und diabète insipide, central idiopathique familial, Acta. Psychiatr. Belg. 80:755.Google Scholar
  22. Gold, P. W., Reuss, V. I., and Goodwin, F. K., 1978, Vasopressin in affective illness, Lancet I:1233.CrossRefGoogle Scholar
  23. Gold, P. W., Weingartner, H., Ballenger, J. C., Goodwin, F. K., and Post, R. M., 1979, Effects of l-desamino-8-D-arginine vasopressin on behaviour and cognition in primary affective disorder, Lancet II:992.CrossRefGoogle Scholar
  24. Grantham, J. J., and Burg, M. B., 1966, Effect of vasopressin and cyclic AMP on permeability of isolated collecting tubules, Am. J. Physiol. 211:255.PubMedGoogle Scholar
  25. Guillemin, R., 1977, The expanding significance of hypothalamic peptides, or, is endocrinology a branch of neuroendocrinology?, Recent Prog. Horm. Res. 33:1.Google Scholar
  26. Jenkins, J. S., Mather, H. M., and Ang, V., 1980, Vasopressin in human cerebrospinal fluid, J. Clin. Endocrinol. Metab. 50:364.PubMedCrossRefGoogle Scholar
  27. Jenkins, J. S., Mather, H. M., Coughlan, A. K., and Jenkins, D. G., 1981, Desmopressin and desglycinamide vasopressin in post-traumatic amnesia, Lancet I:39.CrossRefGoogle Scholar
  28. Korsgaard, S., Casey, D. E., Pacersen, N. E. D., Jorgensen, A., and Gerlach, G., 1980, Vasopressin in anergic schizophrenia, Commun. XIth Int. Congr. Int. Soc. Psychoneuroendocrinol., Florence.Google Scholar
  29. Kovács, G. L., Bohus, B., Versteeg, D. H., de Kloet, E. R., and de Wied, D., 1979, Effect of oxytocin and vasopressin on memory consolidation: Sites of action and catecholaminergic correlates after local microinjection into limbic-midbrain structures, Brain Res. 175:303.PubMedCrossRefGoogle Scholar
  30. Krieger, D. T., and Luria, M., 1977, Plasma ACTH and Cortisol responses to TRF, vasopressin of hypoglycemia in Cushing’s disease and Nelson’s syndrome, J. Clin. Endocrinol. Metab. 44:361.PubMedCrossRefGoogle Scholar
  31. Laszlo, F. A., Laczi, F., Valkusz, Z., Jardanhazy, T., Wagner, A., Szilard, J., and de Wied, D., 1981, Effects of desglycinamide-arginine-vasopressin (DGAVP) on the memory in diabetes insipidus patients, Acta Endocrinol. Suppl. 243:97.Google Scholar
  32. Le Boeuf, A., Lodge, J., and Eames, P. G., 1978, Vasopressin and memory in Korsakoff syndrome, Lancet II:1370.Google Scholar
  33. Legros, J. J., 1975, The radioimmunoassay of human neurophysins: Contribution to the understanding of the physiopathology of neurohypophysial function, Ann. N. Y. Acad. Sci. 248:281.PubMedCrossRefGoogle Scholar
  34. Legros, J. J., and Gilot, P., 1979, Vasopressin and memory in the human, in: Brain Peptides: A New Endocrinology (A. M. Gotto, Jr., E. J. Peck, Jr., and A. E. Boyd, III, eds.), pp. 347–364, Elsevier/North-Holland, Amsterdam.Google Scholar
  35. Legros, J. J., Gilot, P., Seron, X., Ciaessens, J. J., Adam, A., Moeglen, J. M., Audibert, A., and Berchier, P., 1978, Influence of vasopressin on learning and memory, Lancet I:41.CrossRefGoogle Scholar
  36. Legros, J. J., Schmitz, S., Bruwier, M., Mantanus, H., and Timsit-Berthier, M., 1980, Neuro-hypophyseal peptides and cognitive function: A clinical approach, in: Progress in Psycho-neuroendocrinology (F. Brambilla, G. Racagni, and D. de Wied, eds.), pp. 325–337, Elsev-ier/North-Holland, Amsterdam.Google Scholar
  37. Luerssen, T. G., and Robertson, G. L., 1980, Cerebrospinal fluid vasopressin and vasotocin in health, in: Neurobiology of Cerebrospinal Fluid (J. H. Wood, ed.), pp. 613–623, Plenum Press, New York.Google Scholar
  38. McKelvy, J. F., and Epelbaum, J., 1977, Biosynthesis, packaging, transport and release of brain peptides, in: The Hypothalamus (S. Reichlin, R. Baldessarini, and J. Martin, eds.), pp. 195–211, Raven Press, New York.Google Scholar
  39. McKelvy, J. F., Glasel, J. A., and Foreman, M., 1980, Biochemical aspects of hypothalamic function, in: Handbook of the Hypothalamus: Physiology of the Hypothalamus (P. J. Morgane, and J. Panksepp, eds.), pp. 1–61, Dekker, New York.Google Scholar
  40. Mata, M. M., Gainer, H., and Klee, W. A., 1977, Effect of dehydration on the endogenous opiate content of the rat neuro-intermediate lobe, Life Sci. 21:1159.PubMedCrossRefGoogle Scholar
  41. Moore, R. Y., 1978, Central neural control of circadian rhythms, in: Frontiers in N euroendocrinology, Vol. 5 (W. F. Ganong and L. Martini, eds.), pp. 185–206, Raven Press, New York.Google Scholar
  42. Nilaver, G., Zimmerman, E. A., Wilkins, J., Michaels, J., Hoffman, D., and Silverman, A.-J., 1980, Magnocellular hypothalamic projections to the lower brain stem and spinal cord of the rat: Immunocytochemical evidence for predominance of the oxytocin-neurophysin system compared to the vasopressin-neurophysin system, Neuroendocrinology 30:150.PubMedCrossRefGoogle Scholar
  43. Oliver, C., Mical, R. S., and Porter, J. C., 1977, Hypothalamic-pituitary vasculature: evidence for retrograde blood flow in the pituitary stalk, Endocrinology 100:598.CrossRefGoogle Scholar
  44. Oliveros, J. C., Jandali, M. K., Timsit-Berthier, M., Remy, R., Benghezal, A., Audibert, A., and Moeglen, J. M., 1978, Vasopressin in amnesia, Lancet 1:42.PubMedCrossRefGoogle Scholar
  45. Orloff, J., and Handler, J. S., 1962, The similarity of effects of vasopressin, adenosine 3′-5′ phosphate (cyclic AMP) and theophylline on the toad bladder, J. Clin Invest. 41:702.PubMedCrossRefGoogle Scholar
  46. Raichle, M. E., and Grubb, R. L., Jr., 1978, Regulation of brain water permeability by centrally-released vasopressin, Brain Res. 143:191.PubMedCrossRefGoogle Scholar
  47. Robinson, A. G., 1978, Neurophysins, an aid to understanding the structure and function of the neurohypophysis, in: Frontiers in Neuroendocrinology, Vol. 5 (W. F. Ganong and L. Martini, eds.), pp. 35–59, Raven Press, New York.Google Scholar
  48. Rose, S. P. R., and Haywood, J., 1977, Experience, learning and brain metabolism, in: Biochemical Correlates of Brain Structure and Function (A. N. Davison, ed.), pp. 249–292, Academic Press, New York.Google Scholar
  49. Rossier, J., Battenberg, E., Pittman, Q., Bayon, A., Koda, L., Miller, R., Guillemin, R., and Bloom, F., 1979, Hypothalamic enkephalin neurones may regulate the neurohypophysis, Nature (London) 277:653.CrossRefGoogle Scholar
  50. Rossor, M. N., Iversen, L. L., Mountjoy, C. Q., Roth, M., Hawthorn, J., Ang, V. Y., and Jenkins, J. S., 1980, Arginine vasopressin and choline acetyltransferase in brains of patients with Alzheimer type senile dementia, Lancet II:1367.CrossRefGoogle Scholar
  51. Sachs, H., Goodman, R., Osinchak, J., and McKelvy, J., 1971, Supraoptic neurosecretory neurons of the guinea pig in organ culture: Biosynthesis of vasopressin and neurophysin, Proc. Natl. Acad. Sci. USA 68:2782.PubMedCrossRefGoogle Scholar
  52. Scharrer, E., and Scharrer, B., 1954, Hormones produced by neurosecretory cells, Recent Prog. Horm. Res. 10:183.Google Scholar
  53. Simantov, R., and Snyder, S. H., 1977, Opiate receptor binding in the pituitary gland, Brain Res. 124:178.PubMedCrossRefGoogle Scholar
  54. Stillman, M. A., Recht, L. D., Rosario, S. L., Seif, S. M., Robinson, A. G., and Zimmerman, E. A., 1977, The effects of adrenalectomy and glucocorticoid replacement of vasopressin and vasopressin-neurophysin in the zona externa of the median eminence of the rat, Endocrinology 101:42.PubMedCrossRefGoogle Scholar
  55. Sunde, D. A., and Sokol, H. W., 1975, Quantification of rat neurophysins by Polyacrylamide gel electrophoresis (PAGE): Application to the rat with hereditary hypothalamic diabetes insipidus, Ann. N.Y. Acad. Sci. 248:345.PubMedCrossRefGoogle Scholar
  56. Tanaka, M., de Kloet, E. R., de Wied, D., and Versteeg, D. H. G., 1977, Arginine8-vasopressin affects cathecholamine metabolism in specific brain nuclei, Life Sci. 20:1799.PubMedCrossRefGoogle Scholar
  57. Timsit-Berthier, M., Audibert, A., and Moeglen, J. M., 1978a, Influence de la lysine-vasopressine sur l’EEG chez l’homme: Resultats préliminaires, Neuropsychobiology 4:129.PubMedCrossRefGoogle Scholar
  58. Timsit-Berthier, M., Audibert, A., and Moeglen, J. M., 1978b, Modification de l’EEG et de la VCN sous l’effect d’une hormone post-hypophysaire: la lysine Vasopressine (LVP), IIème Congrès Mondial de psychiatrie Biologique, Barcelona, Abstract 438.Google Scholar
  59. Timsit-Berthier, M., Mantanus, H., Jaques, M. C., and Legros, J. J., 1980, Use of lysine-vasopressine in the treatment of post-traumatic amnesia, Acta Psychiatr. Belg. 80:353.Google Scholar
  60. Tinklenberg, J. R., Pfefferbaum, A., and Berger, P. A., 1981, 1-Desamino-D-arginine vasopressin (DDAVP) in cognitively impaired patients Psychopharmacol. Bull. 17:206.Google Scholar
  61. Tinklenberg, J. R., Pigache, R., Pfefferbaum, A., and Berger, P. A., 1982, Vasopressin peptides and dementia, in: Alzheimer’s Disease: A Report of Progress in Research (S. Corkin, K. L. Davis, J. H. Growdon, E. Usdin, and R. J. Wurtmann, eds.), pp. 463–468, Raven Press, New York.Google Scholar
  62. Urban, I., and de Wied, D., 1978, Neuropeptides: Effects on paradoxical sleep and theta rhythm in rats, Pharmacol. Biochem. Behav. 8:51.PubMedCrossRefGoogle Scholar
  63. van Beek-Verbeek, G., Fraenkel, M., Geerlings, P. J., van Ree, J. M., and de Wied, D., 1979, Vasopressin analogue in methadone detoxification of heroin addicts, Lancet II:738.CrossRefGoogle Scholar
  64. van Wimersma Greidanus, T., and Versteeg, D. H. G., 1982, Neurohypophysial hormones: Their role in endocrine function and behavioral homeostasis, in: Behavioral Neuroendocrinology (C. B. Nemeroff and A. J. Dunn, eds.), Spectrum, New York.Google Scholar
  65. Vranckx, C., Minne, P., Benghezal, A., Moeglen, J. M., and Audibert, A., 1979, Vasopressin and schizophrenia, in: Biological Psychiatry Today (J. Obiols, C. Ballus, E. Gonzales Monclus, and J. Pujol, eds.), pp. 753–758, Elsevier/North-Holland, Amsterdam.Google Scholar
  66. Waggoner, R. W., Jr., Slonim, A. E., and Armstrong, S. H., 1978, Improved psychological status of children under DDAVP therapy for central diabetes insipidus, Am. J. Psychiatry 135:361.PubMedGoogle Scholar
  67. Weindl, A., and Sofroniew, M. V., 1980, Immunohistochemical localization of hypothalamic peptide hormones in neural target areas, Brain and Pituitary Peptides, Ferring Symposium, Munich, 1979, pp. 97–109, Karger, Basel.Google Scholar
  68. Weingartner, H., Gold, P., Ballenger, J. C., Smallberg, S. A., Summers, R., Rubinow, D. R., Post, R. M., and Goodwin, F. K., 1981a, Effects ov vasopressin on human memory functions, Science 211:601.PubMedCrossRefGoogle Scholar
  69. Weingartner, H., Kaye, W., Gold, P. H., Smollberg, S., Peterson, R., Gillin, J. C., and Ebert, M., 1981b, Vasopressin treatment of cognitive dysfunction in progressive dementia, Life Sci. 29:2721.PubMedCrossRefGoogle Scholar
  70. Zimmerman, E. A., 1981, The organization of oxytocin and vasopressin pathways, in: Neurosecretion and Brain Peptides (J. B. Martin, S. Reichlin, and K. L. Bick, eds.), pp. 63–75, Raven Press, New York.Google Scholar
  71. Zimmerman, E. A., Carmel, P. W., Husain, M. K., Ferin, M., Tannenbaum, M., Frantz, A. G., and Robinson, A. G., 1973, Vasopressin and neurophysin: High concentrations in monkey hypophyseal portal blood, Science 182:925.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • J. J. Legros
    • 1
  • Ioana Lancranjan
    • 2
  1. 1.Neuroendocrinology SectionChu University of LiègeLiègeBelgium
  2. 2.Department of Clinical ResearchSandoz Ltd.BaselSwitzerland

Personalised recommendations