ACTH4–10 and Memory in Psychiatric Patients

  • Giacomo D’Elia
  • Svend-Otto Frederiksen


Historically the pituitary-adrenal axis has been implicated in the stress response (Selye, 1956), which was thought to be mediated by a target organ away from the brain. Early observations by Thompson and McConnell (1955) and Ungar (1973) indicated, however, that amino acids may directly influence the CNS. The early work of Mirsky et al. (1953) and Miller and Ogawa (1962) indicated a relationship between ACTH and psychological processes, de Wied and Bohus (1966) proposed that ACTH, MSH, and their fragments improved memory.


Psychiatric Patient Memory Retrieval Othe Hand Memory Score Digit Symbol Substitution Test 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Giacomo D’Elia
    • 1
  • Svend-Otto Frederiksen
    • 1
  1. 1.Department of PsychiatryUniversity of LinköpingLinköpingSweden

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