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ACTH4–10

Effects on Pavlovian Conditioning
  • D. A. Powell
  • Shirley L. Buchanan

Abstract

The behavioral effects of a variety of hypothalamic neuropeptides have long been known (e.g., Applezweig and Baudry, 1955; Levine and Jones, 1965). Early experiments by de Wied and his colleagues (e.g., de Wied, 1965, 1969) revealed that adenohypophysectomy produced active avoidance deficits; others have shown that hypophysectomy also impairs passive avoidance behavior (e.g., Weiss et al., 1970). Later experiments revealed that the performance of these animals can be restored by treatment with ACTH peptide fragments with little or no adrenocortical effect, as reviewed recently by de Wied and Gispen (1977) and de Wied (1980).

Keywords

Unconditioned Stimulus Classical Conditioning Pavlovian Conditioning Extinction Session Extinction Training 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ader, R., and de Wied, D., 1972, Effects of vasopressin on active and passive avoidance learning, Psychon. Sci. 29:46.Google Scholar
  2. Applezweig, M. H., and Baudry, F. D., 1955, The pituitary adrenocortical system in avoidance learning, Psychol. Rep. 1:417.Google Scholar
  3. Berger, T. W., Clark, G. A., and Thompson, R. F., 1980, Learning dependent neuronal responses recorded from limbic system brain structures during classical conditioning, Physiol. Psychol. 8:155.Google Scholar
  4. Bohus, B., 1975, Pituitary peptides and autonomic responses, in: Progress in Brain Research, Vol. 42, Hormones, Homeostasis and the Brain (W. H. Gispen, T. B. van Wimersma Greidanus, B. Bohus, and D. de Wied, eds.), pp. 275–283. Elsevier, Amsterdam.Google Scholar
  5. Bohus, B., and de Wied, D., 1967, Avoidance and escape behavior following medial thalamic lesions in rats, J. Comp. Physiol. Psychol. 64:26.PubMedCrossRefGoogle Scholar
  6. Cohen, D. H., and MacDonald, R. L., 1976, Involvement of the avian hypothalamus in defensively conditioned heart rate change, J. Comp. Neurol. 167:465.PubMedCrossRefGoogle Scholar
  7. de Wied, D., 1965, The influence of posterior and intermediate lobe of the pituitary and pituitary peptides on the maintenance of a conditioned avoidance response in rats, Int. J. Neuropharmacol. 4:157.CrossRefGoogle Scholar
  8. de Wied, D., 1969, Effects of peptide hormones on behavior, in: Frontiers in Neuroendocrinology (W. F. Ganong and L. Martini, eds.), pp. 97–140, Oxford University Press, London.Google Scholar
  9. de Wied, D., 1980, Behavioral actions of neurohypophysial peptides, in: Neuroactive Peptides (A. Burgen, H. W. Kosterlitz, and L. L. Iversen, eds.), pp. 183–194, The Royal Society, London.Google Scholar
  10. de Wied, D., and Gispen, W. H., 1977, Behavioral effects of peptides, in: Peptides in Neurobiology (H. Gainer, ed.), pp. 379–448, Plenum Press, New York.Google Scholar
  11. de Wied, D., Bohus, B., and Greven, H. M., 1968, Influence of pituitary and adrenocortical hormones on conditioned avoidance behavior in rats, in: Endocrinology and Human Behavior (R. P. Michael, ed.), pp. 188–199, Oxford University Press, London.Google Scholar
  12. Dogterom, J., and Buijs, R., 1980, Vasopressin and oxytocin distribution in rat brain: Radioimmunoassay and immunocytochemical studies, in: Neuropeptides and Neural Transmission (C. Marsan and W. Tarczyk, eds.), pp. 307–314, Raven Press, New York.Google Scholar
  13. Gabriel, M., Foster, K., Orona, E., and Lambert, R. W., 1980, Early and late acquisition of discriminative neuronal activity during differential conditioning in rabbit: Specificity within the laminae of cingulate, J. Comp. Physiol. Psychol. 94:1069.PubMedCrossRefGoogle Scholar
  14. Gormezano, I., 1966, Classical conditioning, in: Experimental Methods and Instrumentation in Psychology (J. B. Sidowski, ed.), pp. 181–196, McGraw-Hill, New York.Google Scholar
  15. Kelsey, J. E., 1975, Role of pituitary-adrenocortical system in mediating avoidance behavior of rats with septal lesions, J. Comp. Physiol. Psychol. 88:271.PubMedCrossRefGoogle Scholar
  16. Levine, S., and Jones, L. E., 1965, Adrenocorticotrophic hormone (ACTH) and passive avoidance learning, J. Comp. Physiol. Psychol. 59:357.PubMedCrossRefGoogle Scholar
  17. McCormick, D. A., Lavand, D. G., Clark, G. A., Kettner, R. E., Rising, C. E., and Thompson, R. F., 1981, The engram found? Role of the cerebellum in classical conditioning of nictitating membrane and eyelid responses, Bull. Psychon. Soc. 18:103.Google Scholar
  18. Moore, J. W., 1979, Brain processes and conditioning, in: Mechanisms of Learning and Motivation: A Memorial Volume to Jerzy Konorski (A. Dickinson and R. A. Boakes, eds.), pp. 111–142, Erlbaum, Hillsdale, N.J.Google Scholar
  19. Murphy, J. V., and Miller, R. E., 1955, The effect of adrenocorticotropic hormone (ACTH) on avoidance conditioning in the rat. J. Comp. Physiol. Psychol. 48:47.PubMedCrossRefGoogle Scholar
  20. Powell, D. A., and Joseph, J. A., 1974, Autonomic-somatic interaction and hippocampal theta activity, J. Comp. Physiol. Psychol. 87:978.PubMedCrossRefGoogle Scholar
  21. Powell, D. A., and Kazis, E., 1976, Blood pressure and heart rate changes accompanying classical eyeblink conditioning in the rabbit (Oryctolagus cuniculus), Psychophysiology 13:441.PubMedGoogle Scholar
  22. Powell, D. A., Lipkin, M., and Milligan, W. L., 1974, Concomitant changes in classically conditioned heart rate and corneoretinal potential discrimination in the rabbit (Oryctolagus cuniculus), Learn. Motiv. 5:532.Google Scholar
  23. Powell, D. A., Milligan, W. L., and Buchanan, S., 1976, Orienting and classical conditioning in the rabbit (Oryctolagus cuniculus): Effects of septal area lesions, Physiol. Behav. 17:855.CrossRefGoogle Scholar
  24. Powell, D. A., Mankowski, D., and Buchanan, S., 1978, Concomitant heart rate and corneoretinal potential conditioning in the rabbit (Oryctolagus cuniculus): Effects of caudate lesions, Physiol. Behav. 20:143.PubMedCrossRefGoogle Scholar
  25. Sandman, C.A., Kastin, A. J., and Schally, A. V., 1971, Behavioral inhibition as modified by melanocyte-stimulating hormone (MSH) and light-dark conditions, Physiol. Behav. 6:45.PubMedCrossRefGoogle Scholar
  26. Segal, M., and Olds, J., 1973, Activity of units in the hippocampal circuit of the rat during differential classical conditioning, J. Comp. Physiol. Psychol. 82:195.PubMedCrossRefGoogle Scholar
  27. Solomon, P. R., 1977, Role of the hippocampus in blocking and conditioned inhibition of the rabbit’s nictitating membrane response, J. Comp. Physiol. Psychol. 91:407.PubMedCrossRefGoogle Scholar
  28. Solomon, P. R., 1980, A time and place for everything? Temporal processing views of hippocampal function with special reference to attention, Physiol. Psychol. 8:254.Google Scholar
  29. Solomon, P. R., and Moore, J. W., 1975, Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryctolagus cuniculus) following dorsal hippocampal ablation, J. Comp. Physiol. Psychol. 84:145.Google Scholar
  30. Thompson, R. F., Berger, T. W., Cegavske, C. F., Patterson, M. M., Roemer, R. A., Teyler, T. J., and Young, R. A., 1976, The search for the engram, Am. Psychol. 31:209.PubMedCrossRefGoogle Scholar
  31. Thompson, R. F., Berger, T. W., Berry, S. D., Hoehler, F. K., Kettmer, R. E., and Weisz, D. J., 1980, Hippocampal substrates of classical conditioning, Physiol. Psychol. 8:262.Google Scholar
  32. van Wimersma Greidanus, T. B., and de Wied, D., 1971, Effects of systemic and intracerebral administration of two opposite acting ACTH-related peptides on extinction of conditioned avoidance behavior, Neuroendocrinology 7:291.CrossRefGoogle Scholar
  33. van Wimersma Greidanus, T. B., Bohus, B., and de Wied, D., 1974, Differential localization of the influence of lysine vasopressin and of ACTH4–10 on avoidance behavior: A study in rats bearing lesions in the parafascicular nuclei, Neuroendocrinology 14:280.CrossRefGoogle Scholar
  34. Vinogradova, O. S., 1975, The hippocampus and the orienting reflex, in: Neuronal Mechanisms of the Orienting Reflex (E. N. Sokolov and O. S. Vinogradova, eds.), pp. 128–169, Wiley, New York.Google Scholar
  35. Weiss, J. M., McEwen, B. S., Silva, M., and Kalkut, M., 1970, Pituitary-adrenal alterations and fear responding, Am. J. Physiol. 218:864.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • D. A. Powell
    • 1
  • Shirley L. Buchanan
    • 1
  1. 1.Neuroscience Laboratory, Wm. Jennings Bryan Dorn Veterans’ HospitalUniversity of South CarolinaColumbiaUSA

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