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Psychoneuroendocrine Dysfunction pp 209–230Cite as

Neuroendocrine Studies in Huntington’s Disease

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Abstract

During the past 15 years, the neuroendocrine system has been studied in Huntington’s disease (HD) for the purpose of examining underlying hormonal and neurotransmitter abnormalities within the hypothalamic-pituitary axis. Although a clinically overt endocrinopathy has not been described, symptoms of progressive weight loss, disturbances in sweating, and reports of increased fertility in HD women have indeed been observed (Reed and Neel, 1959; Bruyn, 1968; Marx, 1973), and suggest hypothalamic dysfunction in affected individuals. Moreover, postmortem studies of the hypothalamus in HD patients have demonstrated a number of pathological findings including atrophy associated with neuronal cell loss (Vogt and Vogt, 1952; Bruyn, 1973) and alterations in monoamine metabolites (Bernheimer and Hornykiewicz, 1973).

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Authors and Affiliations

  1. Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, 02130, USA

    Raymon Durso

  2. Department of Neurology, University of Rome, Rome, Italy

    Stefano A. Ruggieri & Alessandro Denaro

  3. Department of Psychiatry, University of Maryland, Baltimore, Maryland, 21228, USA

    Carol A. Tamminga

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  1. Raymon Durso
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Editors and Affiliations

  1. Ensor Foundation Research Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) (Director, Research Professor)

  2. Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) & Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Research Professor) &  (Director, Professor and Chairman)

  3. William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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Durso, R., Ruggieri, S.A., Denaro, A., Tamminga, C.A. (1984). Neuroendocrine Studies in Huntington’s Disease. In: Shah, N.S., Donald, A.G. (eds) Psychoneuroendocrine Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4529-9_11

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