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Nonspecific Pituitary Responses to Hypothalamic Hormones in Basic and Clinical Research

  • Daniela Cocchi
  • Vittorio Locatelli
  • Eugenio E. Müller

Abstract

In endocrinology the concept of neurohormonal specificity, e.g., that a specific hypothalamic regulatory hormone (RH) selectively affects the secretion of an anterior pituitary (AP) hormone, has been a tenet for many years. However, in the early 1970s the demonstration by Tashjian et al. (1971) that thyrotropin-releasing hormone (TRH) was capable of affecting prolactin (PRL) release in cultured rat pituitary tumor cells provided strong evidence against that notion. Another hypophysiotropic hormone, e.g., somatostatin, demonstrated an even more evident example of the lack of neurohormonal specificity; in addition to blocking growth hormone (GH) release, it inhibits the secretion of thyrotropin (TSH) but not PRL stimulated by TRH and of an array of gastrointestinal and kidney hormones, e.g., gastrin, secretin, insulin, glucagon, renin, by acting directly on the cells secreting these peptides (for review see Guillemin and Gerich, 1976). Another RH which can be added to this list is luteinizing hormone-releasing hormone (LH-RH), since indisputable evidence has been presented for its ability to induce concurrent release of LH and follicle-stimulating hormone (FSH) from pituitary gonadotropes, and proof for the existence of a distinct FSH-releasing hormone is lacking (Schally et al., 1976). The aforementioned and other endocrine effects of RHs by no means can be referred to as nonspecific, for they occur in either animals or humans under physiologic conditions.

Keywords

Growth Hormone Luteinizing Hormone Anorexia Nervosa Pituitary Adenoma Cirrhotic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Daniela Cocchi
    • 1
  • Vittorio Locatelli
    • 1
  • Eugenio E. Müller
    • 1
  1. 1.Department of Pharmacology, School of MedicineUniversity of MilanMilanItaly

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