Introduction Psychoneuropharmacology and Neuroendocrinology Implications in Neuropsychiatric Research

Implications in Neuropsychiatric Research
  • Arunkumar B. Shah
  • Nandkumar S. Shah
  • Donald W. Morgan
  • Alexander G. Donald


Psychoneuroendocrinology is a fascinating field of study among several disciplines including the neurosciences, neurology, psychiatry, and endocrinology. The last decade has witnessed a phenomenal growth in our understanding of the role of neuroendocrine hormones and neuropeptides in relation to a wide range of psychiatric and neurological disorders. A study of interaction between endocrine hormones and the brain has thus become a rapidly expanding area which has been spurred on by an avalanche of new knowledge. The overlap of the endocrine and nervous systems was well elucidated by classical studies during the first half of this century. The concepts of “neurosecretion,” where the nerve cell could have a secretory function (Scharrer and Scharrer, 1940; Bargmann and Scharrer, 1951), and hypothalamic regulation of anterior pituitary secretion were well documented during that time period (Hinsey and Mar-kee, 1933; Harris, 1952). During the last two decades, advances in immunoassay techniques, immunocytochemistry and biobehavioral assays, have immensely contributed to our knowledge of neuroendocrine relationships with higher cortical functions. A number of hypothalamic peptides involved in the regulation of anterior pituitary secretion have been found in extrahypothalamic areas, and biobehavioral assays have postulated the importance of these peptides in mammalian behavior.


Anorexia Nervosa Growth Hormone Secretion Thyrotropin Release Hormone Senile Dementia Monoamine Neurotransmitter 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Arunkumar B. Shah
    • 1
    • 2
  • Nandkumar S. Shah
    • 1
    • 2
  • Donald W. Morgan
    • 1
    • 2
  • Alexander G. Donald
    • 1
    • 2
  1. 1.Ensor Foundation Research LaboratoryWilliam S. Hall Psychiatric InstituteColumbiaUSA
  2. 2.Department of Neuropsychiatry and Behavioral SciencesUniversity of South Carolina School of MedicineColumbiaUSA

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