Changes in Hormone Uptake and Receptors in the Hypothalamus during Aging

  • Ming-Tsung Peng


With advancing age, female rats tend to show irregular vaginal estrous cycles. By 15–24 months of age, most female rats show a prolonged vaginal cornification, characterized by many well-developed and even cystic follicles, but no evidence of ovulation or formation of corpora lutea (designated as PVC). Some animals during this period show prolonged pseudopregnancies of up to 30 days duration or longer, with numerous corpora lutea (designated as PSP). The oldest rats, 2–3 years of age, often exhibit an anestrous state, characterized by atrophic ovaries with only small or primary follicles and an infantile-appearing uterus (designated as ANE; Aschheim, 1964; Huang and Meites, 1975; Lu et al., 1979).


Preoptic Area Cystic Follicle Estradiol Binding Hormone Uptake Negative Feedback Action 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Ming-Tsung Peng
    • 1
  1. 1.Department of PhysiologyNational Taiwan University Medical SchoolTaipeiTaiwan

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