Advertisement

Changes in Hormone Uptake and Receptors in the Hypothalamus during Aging

  • Ming-Tsung Peng

Abstract

With advancing age, female rats tend to show irregular vaginal estrous cycles. By 15–24 months of age, most female rats show a prolonged vaginal cornification, characterized by many well-developed and even cystic follicles, but no evidence of ovulation or formation of corpora lutea (designated as PVC). Some animals during this period show prolonged pseudopregnancies of up to 30 days duration or longer, with numerous corpora lutea (designated as PSP). The oldest rats, 2–3 years of age, often exhibit an anestrous state, characterized by atrophic ovaries with only small or primary follicles and an infantile-appearing uterus (designated as ANE; Aschheim, 1964; Huang and Meites, 1975; Lu et al., 1979).

Keywords

Preoptic Area Cystic Follicle Estradiol Binding Hormone Uptake Negative Feedback Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, J. N., Peck, E. J., Jr., and Clark, J. H., 1973, Nuclear receptor complex: accumulation, retention and localization in the hypothalamus and pituitary, Endocrinology 93: 711–717.PubMedCrossRefGoogle Scholar
  2. Aschheim, P., 1964, Resultants fournis par la greffe hétérochrone des ovaires dans l’étude regulation hypothalamo-hypophyso-ovarienne de la ratte senile, Gerontologia 10: 65–75.PubMedCrossRefGoogle Scholar
  3. Babichev, V. N., 1973, Characteristics of neurons in the areas of the hypothalamus regulating the gonadotropic function of the hypophysis in old female and male rats, Bull. Exp. Biol. Med. USSR 75:3–5; cit. from Hypothalamus Pituitary and Aging (A. V. Everitt and J. A. Burgess, eds.), Charles C. Thomas, Springfield, Illinois, pp. 376–418.Google Scholar
  4. Chouknyiska, R., and Vassileva-Popova, J. G., 1977, Effect of age on the binding of 3H-testosterone with receptor protein from rat brain and testes, C. R. Acad. Bulg. Sci. 30:133–135; cit. from G. S. Roth, 1979, Hormone receptor changes during adulthood and senescence: Significance for aging research, Fed. Proc. 38: 1910–1914.Google Scholar
  5. Chowers, I., and McCann, S. M., 1961, Comparison of the effect of hypothalamic and pituitary implants of estrogen and testosterone on reproductive system and adrenal of female rats, Proc. Soc. Exp. Biol. Med. 124: 260–266.Google Scholar
  6. Döcke, F., and Dörner, G., 1965, The mechanism of the induction of ovulation by oestrogens, J. Endocrinol. 33: 491–498.PubMedCrossRefGoogle Scholar
  7. Finch, C. E., Felicio, L. S., Flurkey, K., Gee, D. M., Mobbs, C., Nelson, J. F., and Osterburg, H. H., 1980, Studies on ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice, Peptides (Suppl. 1)1:163–175.Google Scholar
  8. Gerlach, J. L., and McEwen, B. S., 1972, Rat brain binds adrenal steroid hormone: Radioautography of hippocampus with corticosterone, Science 175: 1133–1136.PubMedCrossRefGoogle Scholar
  9. Goodman, R. L., 1978, The site of the positive feedback action of estradiol in the rat, Endocrinology 102: 151–159.PubMedCrossRefGoogle Scholar
  10. Gosden, R. G., 1976, Uptake and metabolism in vivo of tritiated estradiol-17-beta in tissues of aging female mice, J. EndocrinoL 68: 153–157.PubMedCrossRefGoogle Scholar
  11. Greenstein, B. D., 1979, Androgen receptors in the rat brain, anterior pituitary gland andGoogle Scholar
  12. ventral prostate gland: Effects of orchidectomy and aging, J. Endocrinol 81:75–81. Hsü, H. K., and Peng, M. T., 1978, Hypothalamic neuron number of old female ratsGoogle Scholar
  13. Huang, H. H., and Meites, J., 1975, Reproductive capacity of aging female rats, Neuroendocrinology 17: 289–295.PubMedCrossRefGoogle Scholar
  14. Jiang, M. J., and Peng, M. T., 1981, Cytoplasmic and nuclear binding of estradiol in the brain and pituitary of old female rats, Gerontology 27: 51–57.Google Scholar
  15. Kalra, S. P., and McCann, S. M., 1975, The stimulatory effect on gonadotropin release of implants of estradiol or progesterone in certain sites in the central nervous system, Neuroendocrinology 19: 289–302.PubMedCrossRefGoogle Scholar
  16. Kanungo, M. S., Patnaik, S. E., and Koul, 0., 1975, Decrease in 1713-estradiol receptor in brain of aging rats, Nature (London) 253: 366–367.CrossRefGoogle Scholar
  17. Korach, K. S., and Muldoon, T. G., 1974, Studies on the nature of the hypothalamic estradiol-concentrating mechanism in the male and female rats, Endocrinology 94: 785–793.PubMedCrossRefGoogle Scholar
  18. Krohn, P. L., 1955, Tissue transplantation technique applied to the problem of the aging of the organ of reproduction, in: Ciba Foundation Colloquia on Aging, General Aspects, Vol. 1 (G. E. W. Wolstenholme and M. P. Cameron, eds.), Little, Brown, Boston, pp. 141–161.Google Scholar
  19. Lin, K. H., Peng, Y. M., Peng, M. T., and Tseng, T. M., 1976, Changes in the nuclearGoogle Scholar
  20. volume of rat hypothalamic neurons in old age, Neuroendocrinology 21:247–254. Lisk, R. D., 1960, Estrogen-sensitive centers in the hypothalamus of the rat, J. Exp. Zool. Google Scholar
  21. Lisk, R. D., 1962, Testosterone-sensitive centers in the hypothalamus of the rat, Acta Endocrinol. (Kbh.) 41: 195–204.Google Scholar
  22. Lu, K. H., Hopper, B. R., Vargo, T. M., and Yen, S. S. C., 1979, Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different reproductive states, Biol. Reprod. 21:193–203.Google Scholar
  23. McEwen, B. S., and Pfaff, D. W., 1973, Chemical and physiological approaches to neuroendocrine mechanisms: Attempts at integration, in: Frontiers in Neuroendocrinology (W. F. Ganong and L. Martini, eds.), Oxford University Press, New York, pp. 267–335.Google Scholar
  24. Moudgil, V. K., and Kanungo, M. S., 1973, Effect of age of the rat on induction of acetylcholinesterase of the brain by 1713-estradiol, Biochim. Biophys. Acta 329: 211–220.PubMedCrossRefGoogle Scholar
  25. Nelson, J. F. Holinka, C. F., Latham, K. R. Allen, J. K., and Finch, C. E., 1976, Corticosterone binding in cytosol from brain regions of mature and senescent male C57BL/ 6J mice, Brain Res. 115:345–351.Google Scholar
  26. Nelson, J. Felicio, L., Sinha, Y. N., and Finch, C. E., 1980, Ovarian hormones and the etiology of reproductive aging in mice, in: Aging Its Chemistry (A. A. Dietz, ed.), Am. Soc. Clin. Chemists, Washington, D. C., pp. 64–81.Google Scholar
  27. Palka, Y., Ramirez, V. D., and Sawyer, C. H., 1966, Distribution and biological effects of tritiated estradiol implanted in the hypothalamo-hypophysial region of female rats, Endocrinology 78: 487–499.PubMedCrossRefGoogle Scholar
  28. Peng, M. T., and Hsü, H. K., 1982, No neuron loss from hypothalamic nuclei of male rats in old age, Gerontology 28: 19–22.PubMedCrossRefGoogle Scholar
  29. Peng, M. T., and Huang, H. H., 1972, Aging of hypothalamic-pituitary-ovarian function in the rat, Fertil. Steril. 23: 535–542.PubMedGoogle Scholar
  30. Peng, M. T., and Peng, Y. M., 1973, Changes in the uptake of tritiated estradiol in thehypothalamus and adenohypophysis of old female rats, Fertil. Steril. 24:534–539. Peng, M. T., Pi, W. P., and Peng, Y. M., 1973, The hypothalamic-pituitary-testicularGoogle Scholar
  31. Pfaff, D. W., 1971, Steroid sex hormones in the rat brain: Specificity of uptake and physiological effects, in: Steroid Hormones and Brain Function ( C. H. Sawyer and R. A. Gorski, eds.), University of California Press, Los Angeles, pp. 103–112.Google Scholar
  32. Pirke, K. M., Geiss, M., and Sintermann, 1978, A quantitative study on feedback control of LH by testosterone in young adult and old male rats, Acta Endocrinol. (Kbh) 89: 789–795.Google Scholar
  33. Ramirez, V. D., Abrams, R. M., and McCann, S. M., 1964, Effect of estradiol implants in the hypothalamo-hypophysial region of the rat on the secretion of luteinizing hormone, Endocrinology 75: 243–248.PubMedCrossRefGoogle Scholar
  34. Riegle, G. D., 1973, Chronic stress effects on adrenocortical responsiveness in young and aged rats, Neuroendocrinology 11:1 –10.Google Scholar
  35. Riegle, G. D., and Hess, G. D., 1972, Chronic and acute dexamethasone suppression of stress activation of the adrenal cortex in young and aged rats, Neuroendocrinology 9: 175–187.PubMedCrossRefGoogle Scholar
  36. Roth, G. S., 1974, Age-related changes in specific glucocorticoid binding by steroid responsive tissues of rats, Endocrinology 94: 82–90.PubMedCrossRefGoogle Scholar
  37. Roth, G. S., 1976, Reduced glucocorticoid binding site concentration in cortical neuronal perikarya from senescent rats, Brain Res. 107: 345–354.PubMedCrossRefGoogle Scholar
  38. Shaar, C. J., Euker, J. S., Riegle, G. D., and Meites, J., 1975, Effects of castration and gonadal steroids on serum luteinizing hormone and prolactin in old and young rats, J. Endocrinol. 66: 45–51.PubMedCrossRefGoogle Scholar
  39. Smith, E. R., and Davidson, J. M., 1967, Differential responses to hypothalamic testosterone in relation to male puberty, Am. J. Physiol. 212: 1385–1390.PubMedGoogle Scholar
  40. Stumpf, W. E., 1968, Estradiol-concentrating neurones: Topography in the hypothalamus by dry mount autoradiography, Science 162: 1001–1003.PubMedCrossRefGoogle Scholar
  41. Stumpf, W. E., 1971, Hypophysiotropic neurons in the periventricular brain: Topography of estradiol concentrating neurons, in: Steroid Hormones and Brain Function (C. H. Sawyer and R. A. Gorski, eds.), University of California Press, Los Angeles, pp. 215–226.Google Scholar
  42. Zeilmaker, G. H., 1969, Effect of prolonged feeding on an ovulatory inhibitor (Lyndiol) on aging of the hypothalamic-ovarian axis and pituitary tumorigenesis in rats, J. Endocrinol. 43: 21–22.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Ming-Tsung Peng
    • 1
  1. 1.Department of PhysiologyNational Taiwan University Medical SchoolTaipeiTaiwan

Personalised recommendations