Relation of the Neuroendocrine System to Development of Prolactin-Secreting Pituitary Tumors

  • Dipak K. Sarkar
  • Paul E. Gottschall
  • Joseph Meites


Prolactin (PRL)-secreting tumors are the most common pituitary tumor type seen in rats, mice, and man (Ito et al., 1972; Post et al.,1980; Schechter et al.,1981; Meites, 1981). Pituitary tumors that secrete growth hormone (GH), adrenocorticotropic hormones (ACTH), and thyroid-stimulating hormone (TSH) also occur in animals and man, and some pituitary tumors secrete several of these hormones simultaneously. In rodents, the incidence of the tumors increases with advancing age, but in human subjects, PRL-secreting pituitary microadenomas occur in young, as well as older individuals, and may increase with aging (Post et al., 1980). Whereas macroscopic pituitary tumors appear most frequently in aging rats and mice, such tumors are much less common in human subjects.


Pituitary Tumor Median Eminence Ergot Alkaloid Prolactin Secretion Kidney Capsule 
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  1. Axelrod, A. A., and LeBlond, C. D., 1955, Induction of thyroid tumors in rats by a low iodine diet, Cancer 8: 339–367.CrossRefGoogle Scholar
  2. Besser, G. M., Yed, T., Delitala, G., and Grossman, D. B., 1980, Alteration of prolactin secretion by centrally acting drugs, Adv. Biochem. Psychopharmacol. 24: 399–406.PubMedGoogle Scholar
  3. Brawer, J. R., Naftolin, F., Martin, J., and Sonnenschein, C., 1978, Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat, Endocrinology 103: 501–512.PubMedCrossRefGoogle Scholar
  4. Brown, G. M., Seeman, P., and Lee, T., 1976, Dopamine-neuroleptic receptors in basal hypothalamus and pituitary, Endocrinology 9: 1407–1410.CrossRefGoogle Scholar
  5. Bulfield, G., and Nahum, A., 1978, Effect of the mouse mutants testicular feminization and sex reversal on hormone mediated induction and repression of enzymes. Biochem. Genet. 16: 743–750.PubMedCrossRefGoogle Scholar
  6. Caron, M. G., Beaulieu, M., Raymond, M., Gagne, B., Droonin, J., Leftkowitz, J., and Labrie, F., 1978, Dopaminergic receptors in the anterior pituitary gland, J. Biol. Chem. 253: 2244–2253.PubMedGoogle Scholar
  7. Casanueva, F., Cocchi, D., Locatelli, V., Flauto, C., Zambotti, F., Bestetti, G., Rossi, G. L., and Müller, E., 1982, Defective central nervous system dopaminergic function in rats with estrogen-induced pituitary tumors, as assessed by plasma prolactin concentrations, Endocrinology 110: 590–599.PubMedCrossRefGoogle Scholar
  8. Chen, C. L., Minaguchi, H., and Meites, J., 1967, Effects of transplanted pituitary tumors on host pituitary prolactin secretion, Proc. Soc. Exp. Biol. Med. 126: 317–320.Google Scholar
  9. Chiodini, P. G., Liuzzi, A., Silvestrini, F., Verde, G., Cozzi, R., Marsili, M. T., Horowski, R., Passerini, F., Luccarelli, G., and Borghi, P. G., 1980, Reduction in size of a prolactinsecreting adenoma during long-term treatment with a dopamine agonist (Lisuride), in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. MacLeod, eds.), Academic Press, New York, pp. 413–418.Google Scholar
  10. Clemens, J. A., and Shaar, C. J., 1980, Control of prolactin secretion in mammals Fed. Proc. 39: 2588–2592.PubMedGoogle Scholar
  11. Clifton, K. H., 1963, Tumor induction in hypophyseal grafts in radiothyroidectomized mice; hypothalamic-hypophyseal relationships, Proc. Soc. Exp. Biol. Med. 114: 559–565.PubMedGoogle Scholar
  12. Clifton, K. H., and Furth, J., 1961, Changes in hormone sensitivity of pituitary mammotropes during progression from normal to autonomous, Cancer Res. 21: 913–920.PubMedGoogle Scholar
  13. Cramer, W., and Horning, E. S., 1936, Experimental production by oestrin of pituitary tumours with hypopituitarism and of mammary cancer, Lancet 1: 247–249.CrossRefGoogle Scholar
  14. Cramer, O. M., Parker, C. R., Jr., and Porter, J. C., 1979a, Estrogen inhibition of dopamine release into hypophysial portal blood, Endocrinology 104: 419–422.PubMedCrossRefGoogle Scholar
  15. Cramer, O. M., Parker, C. R., Jr., and Porter, J. C., 1979b, Secretion of dopamine into hypophysial portal blood by rats bearing prolactin-secreting tumors or ectopic pituitary glands, Endocrinology 105: 636–640.PubMedCrossRefGoogle Scholar
  16. Cronin, M. J., Cheung, C. Y., Weiner, R. I., and Goldsmith, P. C., 1982, Mammotroph and gonadotroph volume percentage in the rat anterior pituitary after lesion of the medial basal hypothalamus, Neuroendocrinology 34: 140–147.PubMedCrossRefGoogle Scholar
  17. Dannies, P. S., and Rudnick, M. S., 1980, 2-bromo-a-ergocryptine causes degradation of prolactin in primary cultures of rat pituitary cells after chronic treatment, J. Biol. Chem. 255: 2776–2781.Google Scholar
  18. Daughaday, W. H., 1980, Presidential address 1, in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. McLeod, eds), Academic Press, New York, pp. 1–2.Google Scholar
  19. DeCamilli, P., Spada, A., Beck-Peccoz, P., Moriondo, P., Giovanelli, M., and Faglia, G., 1980, Presence of a dopamine-sensitive adenylate-cyclase in functioning human pituitary adenomas, in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. McLeod, eds.), Academic Press, New York, pp. 165–172.Google Scholar
  20. DeNicola, A. F., and Von Lawzewitsch, I., Kaplan, S. E., and Libertun, C., 1978, Biochemical and ultrastructural studies on estrogen-induced pituitary tumors in F344 rats, J. Natl. Cancer Inst. 61: 753–757.Google Scholar
  21. El Etreby, M. F., 1980, The role of contraceptive steroids in pathogenesis of tumors in various experimental animals and in man, in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. MacLeod, eds.), Academic Press, New York, pp. 211–222.Google Scholar
  22. Enjalbert, A., Arahcibia, S., Priam, M., Bluet-Pajot, M. T., and Kordon, C., 1982, Neu- rotensin stimulation of prolactin secretion in vitro, Neuroendocrinology 34: 95–98.PubMedCrossRefGoogle Scholar
  23. Eskay, R. L., Oliver, C., Ben Jonathan, N., and Porter, J. C., 1975, Hypothalamic hormones in portal and systemic blood, in: Hypothalamic Hormones: Chemistry, Physiology, Pharmacology and Clinical Uses ( M. Motta, P. G. Crosignani, and L. Martini, eds.), Academic Press, New York, pp. 125–137.Google Scholar
  24. Everett, J. W., 1954, Luteotrophic function of autografts of rat hypophysis, Endocrinology 54: 685–690.PubMedCrossRefGoogle Scholar
  25. Fine, S. A., and Frohman, L. A., 1978, Loss of central nervous system component of dopaminergic inhibition of prolactin secretion in patients with prolactin-secreting pituitary tumors, J. Clin. Invest. 54: 973–980.CrossRefGoogle Scholar
  26. Forman, L. J., Sonntag, W. E., Van Vugt, D. A., and Meites, J., 1981, Immunoreactive 13-endorphin in the plasma, pituitary and hypothalamus of young and old male rats, Neurobiol. Aging 2: 281–284.PubMedCrossRefGoogle Scholar
  27. Furth, J., 1969, Pituitary cybernetics and neoplasia, Harvey Lect. 63: 47–71.PubMedGoogle Scholar
  28. Furth, J., and Clifton, K. H., 1966, Experimental pituitary tumors, in: The Pituitary Gland, Vol. 2 (G. W. Harris and B. T. Donovan, eds.), Butterworth, London, pp. 460-497.Google Scholar
  29. Furth, J., Ueda, G., and Clifton, K. H., 1973, The pathophysiology of pituitaries and their tumors: methodological advances, in: Methods in Cancer Research, Vol. X ( H. Busch, eds.), Academic Press, New York, pp. 200–277.Google Scholar
  30. Fuxe, K., Hökfelt, T., and Nelsson, O., 1969, Factors involved in the control of the activity of the tuberoinfundibular dopamine neurons during pregnancy and lactation, Neuroendocrinology 9: 257–270.CrossRefGoogle Scholar
  31. Gorbman, A., 1949, Tumorous growths in the pituitary and trachea following radiotoxic dosages of I131, Proc. Soc. Exp. Biol. Med. 71: 237–240.PubMedGoogle Scholar
  32. Gudelsky, G. A., and Porter, J. C., 1980, Release of dopamine from tuberoinfundibular neurons in pituitary stalk blood after prolactin or haloperidol administration, Endocrinology 106: 526–529.PubMedCrossRefGoogle Scholar
  33. Gudelsky, G. A., Simpkins, J., Mueller, G. P., Meites, J., and Moore, K. E., 1976, Selective actions of prolactin on catecholamine turnover in the hypothalamus and on serum LH and FSH, Neuroendocrinology 22: 206–215.PubMedCrossRefGoogle Scholar
  34. Gudelsky, G. A., Nansel, D. D., and Porter, J. C., 1981, Role of estrogen in the dopaminergic control of prolactin secretion, Endocrinology 108: 440–444.PubMedCrossRefGoogle Scholar
  35. Hardy, J., 1980, Ten years after the recognition of pituitary microadenomas, in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. MacLeod, eds.), Academic Press, New York, pp. 7–14.Google Scholar
  36. Hoffman, G. E., and Sladek, J. R., Jr., 1980, Age-related changes in dopamine, LHRH, and somatostatin in the rat hypothalamus, Neurobiol. Aging 1: 27–37.PubMedCrossRefGoogle Scholar
  37. Ito, A., Moy, P., Kaunitz, H., Kortwright, K., Clarke, S., Furth, J., and Meites, J., 1972, Incidence and character of the spontaneous pituitary tumors in strain CR and W/FU male rats, J. Natl. Cancer Inst. 49: 701–711.PubMedGoogle Scholar
  38. Kato, Y., Hiroto, S., Katakami, H., Matslishita, N., Shimatsu, A., and Imura, H., 1982, Effects of a synthetic enkephalin analog on plasma luteinizing hormone and prolactin levels in conscious orchidectomized rats, Proc. Soc. Exp. Biol. Med. 169: 95–100.PubMedGoogle Scholar
  39. Lamberts, S. W. J., and MacLeod, R. M., 1979, The inability of bromocryptine to inhibit prolactin secretion by transplantable rat pituitary tumors: Observations on the mechanism and dynamics of the autofeedback regulation of prolactin secretion, Endocrinology 104: 65–70.PubMedCrossRefGoogle Scholar
  40. Lancranjan, I., and Friesen, H. G., 1978, The neural regulation of prolactin secretion, in: Current Studies of Hypothalamic Function ( W. L. Veale and K. Lederis, eds.), S. Karger, Basel, Switzerland, pp. 131–150.Google Scholar
  41. Liuzzi, A., Chiodini, P. G., Silvestrini, F., Cozzi, R., Oppizzi, G., Botalla, L., and Verde, G., 1980, Effects of neuroactive drugs on growth hormone and prolactin secretion in acromegaly, in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. MacLeod, eds.), Academic Press, New York, pp. 367–382.Google Scholar
  42. Lloyd, H. M., Meares, J. D., and Jacobi, J., 1973, Early effects of stilboestrol on growth hormone and prolactin secretion and on pituitary mitotic activity in the male rats, J. Endocrinol. 58: 227–231.PubMedCrossRefGoogle Scholar
  43. Lloyd, H. M., Meares, J. D., and Jacobi, J., 1975, Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells, Nature 255: 497–498.PubMedCrossRefGoogle Scholar
  44. Lu, K. H., Koch, Y., and Meites, J., 1971, Direct inhibition by ergocornine of pituitary prolactin release, Endocrinology 89: 229–233.PubMedCrossRefGoogle Scholar
  45. MacLeod, R. M., and Lehmeyer, J. E., 1974, Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion, Endocrinology 94: 1077–1085.PubMedCrossRefGoogle Scholar
  46. MacLeod, R. M., Lamberts, S. W. J., Nagy, I., Login, I. S., and Valdengro, C. A., 1980, Suppression of prolactin secretion by the physiological and pharmacological manipulation of pituitary dopamine receptors, in: Pituitary Microadenomas ( G. Faglia, N. A. Giovanelli, and R. M. MacLeod, eds.), Academic Press, New York, pp. 37–54.Google Scholar
  47. Malarkey, W. B., Groshong, J. C., and Milo, G. E., 1977, Defective dopaminergic regulation of prolactin secretion in a rat pituitary tumor cell line, Nature 266: 640–641.PubMedCrossRefGoogle Scholar
  48. McEuen, C. S., Selye, H., and Collip, J. B., 1936, Prolonged administration of oestrin in rats, Lancet 1: 775–776.CrossRefGoogle Scholar
  49. McGeer, P. L., and McGeer, E. G., 1978, Aging and Neurotransmitter Systems, Adv. Exp. Med. Biol. 113: 41–68.PubMedGoogle Scholar
  50. Meites, J., 1975, Relation of estrogen to prolactin secretion in animals and man, Adv. Biosci. 15: 196–208.Google Scholar
  51. Meites, J., 1977, Evaluation of research on control of prolactin secretion, in: Comparative Endocrinology of Prolactin ( H. Dellman, J. A. Johnson, and D. M. Klachko, eds.), Plenum Press, New York, pp. 135–152.Google Scholar
  52. Meites, J., 1981, Relation of prolactin to development of spontaneous mammary and pituitary tumors, in: The Prostatic Cell: Structure and Function, Part B ( G. P. Murphy, A. A. Sandbert, and J. P. Karr, eds.), Alan R. Liss, New York, pp. 1–8.Google Scholar
  53. Meites, J., 1982, Changes in neuroendocrine control of anterior pituitary function during aging, Neuroendocrinology 34: 151–156.PubMedCrossRefGoogle Scholar
  54. Meites, J., Simpkins, J. W., Bruni, J., and Advis, J., 1977, Role of biogenic amines in control of anterior pituitary hormones, IRCS J. Med. Sci. 5: 1–7.Google Scholar
  55. Mühlbock, O., and Boot, L. M., 1959, Induction of mammary cancer in mice without the mammary tumor agent by isografts of hypophysis, Cancer Res. 19: 402–412.PubMedGoogle Scholar
  56. Müller, E. E., Genazzani, A. R., Camanni, F., Cocchi, D., Massara, F., Picciolini, E., Locatelli, V., and Molinatti, G. M., 1980, Neuropharmacologic approach to the diagnosis and treatment of secreting pituitary adenomas, in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. MacLeod, eds.), Academic Press, New York, pp. 347–366.Google Scholar
  57. Nagasawa, H., Chen, C. L., and Meites, J., 1969, Effects of estrogen implant in median eminence on serum and pituitary prolactin levels in the rat, Proc. Soc. Exp. Biol. Med. 132: 859–861.PubMedGoogle Scholar
  58. Nakagawa, K., Obara, T., and Tashiro, K., 1980, Pituitary hormones and prolactin-releasing activity in rats with primary estrogen-induced pituitary tumors. Endocrinology 106: 1033–1039.PubMedCrossRefGoogle Scholar
  59. Neill, J. D., 1980, Neuroendocrine regulation of prolactin secretion, in: Frontiers in Neuroendocrinology, Vol. 6 ( L. Martini and W. F. Ganong, eds.), Raven Press, New York, pp. 129–155.Google Scholar
  60. Nicoll, C. S., and Meites, J., 1962, Estrogen stimulation of prolactin production by rat adenohypophysis in vitro, Endocrinology 70: 272–277.PubMedCrossRefGoogle Scholar
  61. Nilius, S. J., Bergh, T., Lundberg, P. O., Stahle, J., and Wide, L., 1980, Bromocryptineinduced regression of a prolactin-secreting pituitary tumor, in: Pituitary Microadenomas ( G. Faglia, M. A. Giovanelli, and R. M. McLeod, eds.), Academic Press, New York, pp. 407–412.Google Scholar
  62. Pawlikowski, M., 1982, The link between secretion and mitosis in the endocrine glands, Life Sci. 30: 315–320.PubMedCrossRefGoogle Scholar
  63. Pilotte, N. S., and Porter, J. C., 1980, Concentration of dopamine in pituitary stalk plasma and of prolactin in systemic plasma in rats given 5-hydroxytryptamine, Soc. Neurosci. Abst. 6: (34).Google Scholar
  64. Porter, J. C., Nansel, D. D., Gudelsky, G. A., Reymond, M. J., Pilotte, N. S., Foreman, M. M., and Tilders, F. J. H., 1980, Some aspects of hypothalamic and hypophysial secretion in aging rats, Peptides 1: 135–139.CrossRefGoogle Scholar
  65. Post, K. D., Jackson, I. M. D., and Reichlin, S., 1980, The Pituitary Adenoma, Plenum Publishing, New York.CrossRefGoogle Scholar
  66. Prysor-Jones, R. A., and Jenkins, J. S., 1980, Effect of bromocryptine, ergotamine, and other ergot alkaloids on the hormone secretion and growth of a rat pituitary tumor. J. Endocrinol. 86: 147–153.PubMedCrossRefGoogle Scholar
  67. Quadri, S. K., and Meites, J., 1973, Effects of ergocornine and CG603 on blood prolactin and GH in rats bearing a pituitary tumor, Proc. Soc. Exp. Biol. Med. 142: 837–841.PubMedGoogle Scholar
  68. Quadri, S. K., Lu, K. H., and Meites, J., 1972, Ergot-induced inhibition of pituitary tumor growth in rats, Science 176: 417–418.PubMedCrossRefGoogle Scholar
  69. Ratner, A., and Meites, J., 1964, Depletion of prolactin-inhibiting activity of rat hypothalamus by estradiol or suckling stimulus, Endocrinology 75: 377–382.PubMedCrossRefGoogle Scholar
  70. Raymond, V., Beaulieu, M., Labri, F., and Boissier, J., 1978, Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release, Science 200: 1173–1175.PubMedCrossRefGoogle Scholar
  71. Rennels, E. G., 1962, An electron microscope study of pituitary autograft cells in the rat, Endocrinology 71: 713–722.PubMedCrossRefGoogle Scholar
  72. Robinson, D. S., Nies, A., Davis, J., Bunney, W. E., Davis, J. M., Colburn, R. W., Bourne, H. R., Shaw, D. M., and Coppen, A. J., 1972, Aging, monoamines, and monoamineoxidase levels, Lancet 1: 290–291.PubMedCrossRefGoogle Scholar
  73. Rossi, G. L., Probst, D., Panerai, A. E., Gil-Ad, I., Cocchi, D., and Müller, E. E., 1977, Light and electron microscopic studies of thyrotrophin releasing hormone-induced growth hormone and prolactin release in hypophysectomized rats bearing an ectopic pituitary, J. Endocrinol. 72: 313–319.PubMedCrossRefGoogle Scholar
  74. Rossi, G. L., Probst, D., Panerai, A. E., Cocchi, D., Locatelli, V., and Müller, E. E., 1979, Ultrastructure of somatotrophs of rats with median eminence lesions: Studies in basal conditions and after thyrotropin-releasing hormone stimulation, Neuroendocrinology 29: 100–109.PubMedCrossRefGoogle Scholar
  75. Russfield, A. B., 1966, Tumors of Endocrine Glands and Secondary Sex Organs, Pub. No. 1332, U. S. Government Printing Office, Washington.Google Scholar
  76. Said, S. I., and Porter, J. C., 1979, Vasoactive intestinal polypeptide: Release into hypophyseal portal blood, Life Sci. 24: 227–230.PubMedCrossRefGoogle Scholar
  77. Sarkar, D. K., Miki, N., Xie, Q. W., Sylvester, P. W., and Meites, J., 1982a, Estrogen can inhibit “short-loop-feedback” action of prolactin on prolactin release, Soc. Endocrinol. (Abst. 864 ).Google Scholar
  78. Sarkar, D. K., Gottschall, P. E., Meites, J., Horn, A., Dow, R. C., Fink, G., and Cuello, A. C., 1982b, Uptake and release of 3H-dopamine by the median eminence: Evidence for presynaptic dopaminergic receptors and for dopaminergic feedback inhibition, Neuroscience (in press).Google Scholar
  79. Sarkar, D. K., Gottschall, P. E., and Meites, J., 1982c, Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors, Science 218: 684–686.PubMedCrossRefGoogle Scholar
  80. Schechter, J. E., Felicio, L. S., Nelson, J. F., and Finch, C. E., 1981, Pituitary tumorigenesis in aging female C57BL/6J mice: A light and electron microscopic study, Anat. Rec. 199: 423–432.PubMedCrossRefGoogle Scholar
  81. Seeman, P., 1980, Brain dopamine receptors, Pharmacol. Rev. 32: 229–313.PubMedGoogle Scholar
  82. Shaar, C. J., Clemens, J. A., and Dininger, N. B., 1979, Effect of vasoactive intestinal polypeptide on prolactin release in vitro, Life Sci. 25: 2071–2074.PubMedCrossRefGoogle Scholar
  83. Simpkins, J. W., Mueller, G. P., Huang, H. H., and Meites, J., 1977, Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: Possible relation to gonadotropin secretion, Endocrinology 100: 1672–1678.PubMedCrossRefGoogle Scholar
  84. Steger, R. W., Sonntag, W. E., Van Vugt, D. A., Forman, L. J., and Meites, J., 1980, Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met’-enkephalin, Life Sci. 27: 747–753.PubMedCrossRefGoogle Scholar
  85. Tashjian, A. H., Jr., Barowsky, N. J., and Jensen, D. K., 1971, Thyrotropin releasing hormone: Direct evidence for stimulation of prolactin production by pituitary cells in culture, Biochem. Biophys. Res. Commun. 43: 516–523.PubMedCrossRefGoogle Scholar
  86. Upton, A. C., and Furth, J., 1953, Induction of pituitary tumors by means of ionizing radiation, Proc. Soc. Exp. Biol. 84: 255–257.PubMedGoogle Scholar
  87. Valotaire, Y., LeGuellec, R., Kercret, H., Gullaen, G., and Duval, J., 1975, Induction of rat pituitary thymidine kinase: Another physiological response to oestradiol in the male? Mol. Cell Endocrinol. 3: 117–127.PubMedCrossRefGoogle Scholar
  88. Van Vugt, D. A., Bruni, J. F., Sylvester, P. W., Chen, H. T., Leiri, T., and Meites, J., 1979, Interaction between opiates and hypothalamic dopamine on prolactin release, Life Sci. 24: 2361–2368.PubMedCrossRefGoogle Scholar
  89. Welsch, C. W., Negro-Vilar, A., and Meites, J., 1968, Effects of pituitary homografts on host pituitary prolactin and hypothalamic PIF levels, Neuroendocrinology 3: 238–245.PubMedCrossRefGoogle Scholar
  90. Welsch, C. W., Jenkins, T., Amenomori, Y., and Meites, J., 1971, Tumorous development of in situ and grafted anterior pituitaries in female rats treated with diethylstilbesterol, Experientia 27: 1350–1352.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Dipak K. Sarkar
    • 1
  • Paul E. Gottschall
    • 2
  • Joseph Meites
    • 2
  1. 1.Department of Reproductive MedicineUniversity of CaliforniaSan DiegoUSA
  2. 2.Department of Physiology, Neuroendocrine Research LaboratoryMichigan State UniversityEast LansingUSA

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