Regulation of Thyrotropin Physiology during Aging

  • Robert I. Gregerman


The relationship of age to the functional state of the hypothalamic-pituitary-thyroid axis has been studied in a variety of ways to both animals and man. Basal concentrations of pituitary and of blood thyrotropin (TSH) have been measured and attempts made to relate these to circulating concentrations of the thyroid hormones. Thyrotropin-releasing hormone (TRH) has been administered to provoke pituitary secretion of TSH. The immunologic and functional characteristics of pituitary and blood TSH have been examined. Intact animals have been subjected to maneuvers (stress) which affect the secretion of TSH. It is safe to conclude from all of these observations that age certainly has an influence on the parameters studied, but the information that has thus far emerged from studies in animals and man is incomplete and does not fall into a single pattern.


Thyroid Hormone Circulate Thyroid Hormone Augmented Release Euthyroid Sick Syndrome Thyroid Hormone Binding 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Robert I. Gregerman
    • 1
  1. 1.Gerontology Research Center, National Institute on AgingNIH, Baltimore City HospitalBaltimoreUSA

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