Homologs of CRP: A Diverse Family of Proteins with Similar Structure

  • John E. Coe

Abstract

Human C-reactive protein (CRP) was first noted over 50 years ago (Tillet and Francis, 1930) as a serum protein that rapidly increased in concentration in diseased patients. Inflammation or injury will nonspecifically cause a variety of serum constituents to fluctuate from normal levels; these proteins are designated acute phase reactants (Owen, 1967). However, human CRP is regarded as the archetype acute phase protein because of its relatively long history and impressive serum changes as an acute reactant. Since the discovery of CRP, numerous investigators have puzzled over its function in inflammation. Another protein, a constituent of human amyloid called amyloid P (AP) component, has been shown to be homologous to CRP (Osmand et al., 1977a; Levo et al., 1977). Because these proteins have been the subject of several excellent current reviews (Koj, 1974; Kushner, 1981; Gewurz et al., 1982;Pepys, 1981;Kushner et al., 1982), this chapter will deal primarily with the expression of proteins homologous with human CRP and AP that have been identified in other animals. In general, these two proteins are represented in a wide variety of species, from fishes to mammals, and a conservative evolution has resulted in functional characteristics similar to those of their human counterparts. These proteins also have a similar unique structure.

Keywords

Depression Albumin Agarose Heparin Polysaccharide 

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References

  1. Abernethy, T. J., and Avery, O. T., 1941, J. Exp. Med. 73:173.Google Scholar
  2. Adler, S., 1948,Nature (London) 162:256.Google Scholar
  3. Anderson, H. C., and McCarthy, M., 1951, J. Exp. Med. 93:25.Google Scholar
  4. Anderson, J. K., and Mole, J. E., 1982, Ann. N. Y. Acad. Sci. 389:216.Google Scholar
  5. Baldo, B. A., and Fletcher, T. C., 1913, Nature(London) 246:145.Google Scholar
  6. Baldo, B. A., Krilis, S., and Fletcher, T. C., 1979, Naturwissenschaften 66:623.Google Scholar
  7. Baltz, M. L., Gomer, K., Davies, A. J. S., Evans, D. J., Klaus, G. G. B., and Pepys, M. B., 1980a, Clin. Exp. Immunol. 39:355.Google Scholar
  8. Baltz, M. L., Dyck, R. F., and Pepys, M. B., 1980b, Immunology 41:59.Google Scholar
  9. Baltz, M. L., Rogers, S. L., Gomer, K., Davies, A. J. S., Doenhoff, M. J., Klaus, G. G. B., and Pepys, M. B., 1980C., in: Amyloid and Amyloidosis(G. G. Glenner, P. Pinho e Costa, and A. F. de Freitas, eds.), p. 534, Excerpta Medica, Amsterdam.Google Scholar
  10. Bladen, H. A., Nylen, M. V., and Glennev, G. G., 1966, J. Ultrastruct. Res. 14:449.Google Scholar
  11. Bornstein, D. L., and Walsh, E. C., 1978, J Lab. Clin. Med. 91:236.Google Scholar
  12. Breathnach, S. M., Bhogal, B., Dyck, R. F., DeBeer, F. C., Black, M. M., and Pepys, M. B., 1981, Br. J. Dermatol. 105:115.Google Scholar
  13. Cathcart, E. S., Comerford, I. R., and Cohen, A. S., 1965,N. Engl. J. Med.273:143.Google Scholar
  14. Chelladurai, M., Maclntyre, S. S., and Kushner, I., 1982, Fed. Proc.41:868 (abstr.).Google Scholar
  15. Churchill, W. H., Jr., Weintraub, R. M., Borsos, T., and Rapp, H. J., 1967, J. Exp. Med. 125:657.Google Scholar
  16. Claus, D. R., Osmand, A. P., and Gewürz, H., 1976, J. Lab. Clin. Med. 87:120.Google Scholar
  17. Coe, J. E., 1970, J. Immunol 104:1166.Google Scholar
  18. Coe, J. E., 1977, Proc. Natl. Acad. Sci U.S.A. 74:730.Google Scholar
  19. Coe, J. E., 1978, Fed. Proc. 37:2030.Google Scholar
  20. Coe, J. E., 1981, in: Hamster Immune Responses in Infectious and Oncological Diseases(J. W. Streilein, D. A. Hart, J. Steinz Streilein, W. R. Duncan, and R. E. Billingham, eds.), p. 95, Plenum Press, New York.Google Scholar
  21. Coe, J. E., 1982,Ann. N. Y. Acad Sci. 389:299.Google Scholar
  22. Coe, J. E., and Ross, M. J., 1983, J. Exp. Med (in press).Google Scholar
  23. Coe, J. E., Margossian, S. S., Slayter, H. S., and Sogn, J. A., 1981, J. Exp. Med. 153:977.Google Scholar
  24. Cohn, M., 1967, Cold Spring Harbor Symp. Quant. Biol. 32:211.Google Scholar
  25. DeBeer, F. C., Baltz, M. L., Holford, S., Feinstein, A., and Pepys, M. B., 1981,J. Exp. Med.154:1134.Google Scholar
  26. DeBeer, F. C., Baltz, M. L., Munn, E. A., Feinstein, A., Taylor, J., Bruton, C., Clamp, J. R., and Pepys, M. B., 1982,Immunology 45:55.Google Scholar
  27. DiCamelli, R., Potempa, L. A., Siegel, J., Suyehira, L., Petras, K., and Gewurz, H., 1980, J. Immunol. 125:1933.Google Scholar
  28. DuClos, T. W., Mold, C., Paterson, P. K., Alroy, J., and Gewurz, H., 1981, Clin. Exp. Immunol. 43:565.Google Scholar
  29. Dyck, R. F., Lockwood, C. M., Kershaw, M., McHugh, N., Duance, V., Baltz, M. L., and Pepys, M. B., 1980, J. Exp. Med.152:1162.Google Scholar
  30. Engelman, F., 1969, Science 165:407.Google Scholar
  31. Fletcher, T. C., and Baldo, B. A., 1976, Experientia 32:1199.Google Scholar
  32. Fletcher, T. C., White, A., Youngston, A., Pusztai, A., and Baldo, B. A., 1981, Biochim. Biophys. Acta 671:44.Google Scholar
  33. Gewurz, H., Mold, C., Siegel, J., and Fiedel, B., 1982, Adv. Intern. Med. 27:345.Google Scholar
  34. Glenner, G. G., 1980,N. Engl. J. Med.302:1283.Google Scholar
  35. Gotschlich, E. C., 1962, Fed. Proc. 21:14.Google Scholar
  36. Gotschlich, E. C., and Edelman, G. M., 1965, Proc. Natl. Acad. Sci. U.S.A.54:558.Google Scholar
  37. Gotschlich, E. C., and Edelman, G. M., 1967, Proc. Natl. Acad. Sci. U.S.A. 57:706.Google Scholar
  38. Gotschlich, E. C., and Stetson, C. A., 1960, J. Exp. Med. 111:441.Google Scholar
  39. Hurlimann, J., Thorbecke, G. J., and Hochwald, G. M., 1966, J. Exp. Med. 123:367.Google Scholar
  40. Hutchcraft, C., Gewurz, H., Hansen, B., Dyck, R. F., and Pepys, M. B., 1981, J. Immunol. 126:1217.Google Scholar
  41. Kabat, E. A., Wu, T. T., and Bilofsky, H., 1976, Proc. Natl. Acad. Sci. U.S.A. 73:617.Google Scholar
  42. Kaplan, M. H., and Volanakis, J. E., 1974, J. Immunol 112:2135.Google Scholar
  43. Kindmark, C.-O., 1971,Clin. Exp. Immunol 8:941.Google Scholar
  44. Kindmark, C.-O., 1972,Clin. Exp. Immunol 11:283.Google Scholar
  45. Kirkman, H., 1957,Cancer 10:757.Google Scholar
  46. Koj, A., 1974, in: Structure and Function of Plasma Proteins, Volume 1 (A. C. Allison, ed.), p. 73, Plenum Press, New York.Google Scholar
  47. Kushner, I., 1981, in: Textbook of Rheumatology (W. N. Kelley, E. D. Harris, Jr., S. Ruddy, and C. B. Sledge, eds.), p. 669, W. B. Saunders, Philadelphia.Google Scholar
  48. Kushner, I., Rakita, L., and Kaplan, M. H., 1963, J. Clin. Invest.42:286.Google Scholar
  49. Kushner, I., Ribich, W. N., and Blair, J. B., 1980,J. Lab. Clin. Med. 96:1037.Google Scholar
  50. Kushner, I., Volanakis, J. E., and Gewurz, H. (eds.), 1982, C-Reactive Protein and the Plasma Protein Response to Tissue Injury, Ann. N. Y. Acad. Sci. 389.Google Scholar
  51. Laskowski, M., 1935, Biochem. Z. 278:345.Google Scholar
  52. Levo, Y., Frangione, B., and Franklin, E. C., 1977, Nature (London) 268:56.Google Scholar
  53. Li, J. J., McAdam, P. W. J., Miercio, E. A., and Pereira, J., 1982, Fed. Proc. 41:813 (abstr.).Google Scholar
  54. Lieberman, R., Potter, M., Mushinski, E. B., Humprey, W., Jr., and Rudikoff, S., 1974, J. Exp. Med. 139:983.Google Scholar
  55. Liu, T., Robey, F. A., and Wang, C. H., Ann. N. Y. Acad. Sci. 389:151.Google Scholar
  56. MacLeod, C. M., and Avery, O. T., 1941, J. Exp. Med. 73:183.Google Scholar
  57. Mardiney, M. R., Muller-Eberhard, J. R., and Muller-Eberhard, H. J., 1965, J. Immunol. 94:877.PubMedGoogle Scholar
  58. Merriman, C. R., Pulliam, L. A., and Kampschmidt, R. F., 1975, Proc. Soc. Exp. Biol. Med. 149:782.PubMedGoogle Scholar
  59. Mold, C., Nakayama, S., Holzer, T. J., Gewurz, H., and DuClos, T. W., 1981, J. Exp. Med. 154:1703.PubMedCrossRefGoogle Scholar
  60. Murphy, M. R., 1971, Am. Zool. 11:632.Google Scholar
  61. Nagpurkar, A., and Mookerjea, S., 1981, J. Biol. Chem. 256:7440.PubMedGoogle Scholar
  62. Oliveira, E. B., Gotschlich, E. C., and Liu, T.-Y., 1979, J. Biol. Chem. 254:489.PubMedGoogle Scholar
  63. Oliveira, E. B., Gotschlich, E. C., and Liu, T.-Y., 1980, J. Immunol.124:1396.PubMedGoogle Scholar
  64. Osmand, A. P., Friedenson, B., Gewurz, H., Painter, R. H., Hoffman, T., and Shelton, E.,1977a, Proc. Natl. Acad. Sci. U.S.A. 74:739.PubMedCrossRefGoogle Scholar
  65. Osmand, A. P., Gewurz, H., and Friedenson, B., 1977b, Proc. Natl. Acad. Sci. U.S.A. 74: 1214.PubMedCrossRefGoogle Scholar
  66. Owen, J. A., 1967, in: Advances in Clinical Chemistry, Volume 9 (H. Sobotka and C. P. Stewart, eds.), p. 1, Academic Press, New York/London.Google Scholar
  67. Painter, R. H., 1977, J. Immunol.119:2203.PubMedGoogle Scholar
  68. Painter, R. H., Pinteric, L., Hotman, T., Keils, D. I. C., and Katz, A., 1976, J. Immunol.116:1745.Google Scholar
  69. Parish, W. E., 1977, in: Bayer Symposium IV: Experimental Models of Chronic Inflammatory Diseases (L. E. Glynn and H. D. Schlumberger, eds.), p. 117, Springer-Verlag, Berlin.Google Scholar
  70. Parviz Pour, N., Moch, K., Greiser, E., Mohr, U., Althoff, J., and Cardesa, A., 1976,J. Natl. Cancer Inst. 56:931.Google Scholar
  71. Passmore, H. C., and Shreffler, D. C., 1971, Biochem. Genet. 5:201.PubMedCrossRefGoogle Scholar
  72. Pearlstein, E., Gold, L. I., and Garcia-Pardo, A., 1981, Mol. Cell. Biochem. 29:103.Google Scholar
  73. Pepys, M. B., 1981,Lancet 1:653.PubMedCrossRefGoogle Scholar
  74. Pepys, M. B., Dash, A. C., Mumm, E. A., Feinstein, A., Skinner, M., Cohen, A. S., Gewurz, H., Osmand, A. P., and Painter, R. H., 1977, Lancet 1:1029.PubMedCrossRefGoogle Scholar
  75. Pepys, M. B., Dash, A. C., Fletcher, T. C., Richardson, N.,Mumm, E. A., and Feinstein, A., 1978a, Nature (London) 273:168.CrossRefGoogle Scholar
  76. Pepys, M. B., Dash, A. C., Markham, R. E., Thomas, H. C., Williams, B. D., and Petrie, A., 1978b, Gin. Exp. Immunol. 32:119.Google Scholar
  77. Pepys, M. B., Baltz, M., Gomer, K., Davies, A. J. S., and Doenhoff, M., 1979a, Nature(London) 278:259.CrossRefGoogle Scholar
  78. Pepys, M. B., Dyck, R. F., DeBeer, F. C., Skinner, M., and Cohen, A. S., 1979b,Clin. Exp. Immunol. 38:284.PubMedGoogle Scholar
  79. Pepys, M. B., Baltz, M. L., Dyck, R. F., DeBeer, F. C., Evans, D. J., Feinstein, A., Milstein, C. P., Mumm, E. A., Richardson, N., Murch, J. F., Fletcher, T. C., Davies, A. J. S., Gomer, K., Cohen, A. S., Skinner, M., and Klaus, G. G. B., 1980, in: Amyloid and Amyloidosis (G. G. Glenner, P. Pinho e Costa, and A. F. de Freitas, eds.), p. 373, Excerpta Medica, Amsterdam.Google Scholar
  80. Pinteric, L., and Painter, R. H., 1979, Can. J. Biochem. 57:727.PubMedCrossRefGoogle Scholar
  81. Pinteric, L., Assimeh, S. N., Kells, D. I. C., and Painter, R. H., 1976, J. Immunol 117:79.PubMedGoogle Scholar
  82. Pontet, M., D’Asnieres, M., Gache, D., Escaig, J., and Engler, R., 1981, Biochim. Biophys. Acta 671:202.PubMedCrossRefGoogle Scholar
  83. Reiter, R. J., 1974,Chronobiologia 1:365.PubMedGoogle Scholar
  84. Rhodes, K., Markham, R. L., Maxwell, P. M., and Monk-Jones, M. E., 1969, Br. Med. J.3:439.PubMedCrossRefGoogle Scholar
  85. Robey, F. A., and Liu, T.-Y., 1981, J. Biol. Chem. 256:969.PubMedGoogle Scholar
  86. Robinson, R., 1968, in: The Golden Hamster: Its Biology and Use in Medical Research(R. A. Hoffman, P. F. Robinson, and H. Magalhaes, eds.), p. 41, Iowa State University Press,Ames.Google Scholar
  87. Saba, T. M., and Jaffe, F., 1980, Am. J. Med. 68:577.PubMedCrossRefGoogle Scholar
  88. Schjeide, O. A., and Urist, M. R., 1956, Science 124:1242.PubMedCrossRefGoogle Scholar
  89. Siegel, J., Rent, R., and Gewurz, H., 1974, J. Exp. Med.140:631.PubMedCrossRefGoogle Scholar
  90. Skinner, M., Cohen, A. S., Shirahama, T., and Cathcart, E. S., 1974, J. Lab. Clin. Med. 84:604.PubMedGoogle Scholar
  91. Skinner, M., Pepys, M. B., Cohen, A. S., Heller, L. M., and Lian, J. B., 1980, in: Amyloid and Amyloidosis (G. G. Glenner, P. Pinho e Costa, and A. F. de Freitas, eds.), p. 384, Excerpta Medica, Amsterdam.Google Scholar
  92. Skinner, M., Sipe, J., Cohen, A. S., and Yood, R., 1982, Ann. N. Y. Acad. Sci. 389:190.PubMedCrossRefGoogle Scholar
  93. Tillett, W. S., and Francis, T., Jr., 1930,J. Exp. Med. 52:561.PubMedCrossRefGoogle Scholar
  94. Turek, F. W., Elliott, J. A., Alvis, J. D., and Menaker, M., 1975, Biol. Reprod. 13:475.PubMedCrossRefGoogle Scholar
  95. Urbach, G., and Cinader, B., 1966, Proc. Soc. Exp. Biol. Med. 122:779.PubMedGoogle Scholar
  96. Volanakis, J. E., and Kaplan, M. H., 1971,Proc. Soc. Exp. Biol. Med. 136:612.PubMedGoogle Scholar
  97. Volanakis, J. E., and Kearney, J. F., 1981,J. Exp. Med. 153:1604.PubMedCrossRefGoogle Scholar
  98. Volanakis, J. E., and Narkates, A. J., 1981,J. Immunol. 126:1820.PubMedGoogle Scholar
  99. Volanakis, J. E., and Wirtz, K. W. A., 1979, Nature (London) 281:155.PubMedCrossRefGoogle Scholar
  100. Whicher, J. T., Martin, J. F. R., and Dieppe, P. A., 1980, Lancet 2:1187.PubMedCrossRefGoogle Scholar
  101. White, A., Fletcher, T. C., Pepys, M. B., and Baldo, B. A., 1981, Comp. Biochem. Physiol 69:325.CrossRefGoogle Scholar
  102. Young, N. M., and Williams, R. E., 1978, J. Immunol 121:1893.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John E. Coe
    • 1
  1. 1.Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health ServiceU.S. Department of Health and Human ServicesHamiltonUSA

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