Human Immunoregulatory Molecules: Interleukin 1, Interleukin 2. and B-Cell Growth Factor
Intensive investigations over the past several years have clearly indicated that a significant degree of immune regulation is accomplished by soluble mediators. Among the host of potential immune regulators that have been described to date, the interleukins have been the most fully characterized. Yet many aspects of both the biochemistry and the cell biology of these factors remain to be determined. In an attempt to place some of the areas of current investigational interest into perspective, a brief historical overview of each factor will be undertaken. This historical overview will detail our knowledge of the biochemical properties attributed to each factor when first described. This latter point will be of significance in our subsequent attempts to unravel the biological properties of each factor and how it mediates those effects that lead to a competent immune response.
KeywordsConditioned Medium Mouse Thymocyte Acute Monocytic Leukemia Normal Human Peripheral Blood Mammalian Cell Proliferation
Unable to display preview. Download preview PDF.
- Aarden, L. A., et al., 1979, J. Immunol. 123:2928.Google Scholar
- Gillis, S., Mochizuki, D. Y., Conlon, P. J., Hefeneider, S. H., Ramthun, C. A., Gillis, A. E.,Google Scholar
- Lachman, L. B., 1983, Fed. Proc. (in press).Google Scholar
- Maizel, A. L., Sahasrabuddhe, C., Mehta, S., Morgan, J., Lachman, L., and Ford, R. J., 1982b, UCLA Symp. Mol Cell. Biol. 24:197.Google Scholar
- Maizel, A. L., Mehta, S., Kouttab, N., Morgan, J., Ford, R., and Sahasrabuddhe, C., 1983, Fed. Proc. (in press).Google Scholar
- Ruscetti, F. W., and Gallo, R. C., 1981, Blood 57:359.Google Scholar