Human Immunoregulatory Molecules: Interleukin 1, Interleukin 2. and B-Cell Growth Factor

  • Lawrence B. Lachman
  • Abby L. Maizel


Intensive investigations over the past several years have clearly indicated that a significant degree of immune regulation is accomplished by soluble mediators. Among the host of potential immune regulators that have been described to date, the interleukins have been the most fully characterized. Yet many aspects of both the biochemistry and the cell biology of these factors remain to be determined. In an attempt to place some of the areas of current investigational interest into perspective, a brief historical overview of each factor will be undertaken. This historical overview will detail our knowledge of the biochemical properties attributed to each factor when first described. This latter point will be of significance in our subsequent attempts to unravel the biological properties of each factor and how it mediates those effects that lead to a competent immune response.


Conditioned Medium Mouse Thymocyte Acute Monocytic Leukemia Normal Human Peripheral Blood Mammalian Cell Proliferation 
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  1. Aarden, L. A., et al., 1979, J. Immunol. 123:2928.Google Scholar
  2. Andersson, J., and Melchers, F., 1981, Proc. Natl. Acad. Sci.U.S.A. 78:2497.CrossRefGoogle Scholar
  3. Bonnard, G. D., Yasaka, D., and Jacobson, D., 1979, J. Immunol 123:2704.PubMedGoogle Scholar
  4. Duncan, M. R., George, F. W., and Hadden, J. W., 1982, J. Immunol 129:56.PubMedGoogle Scholar
  5. Farrar, J. J., Benjamin, W. R., Hilfiker, M. D., Howard, M., Farrar, W. L., and Farrar, J.-F., 1982, Immunol. Rev. 63:129.PubMedCrossRefGoogle Scholar
  6. Ford, R. J., Mehta, S. R., Franzini, D., Montagna, R., Lachman, L., and Maizel, A. L., 1981, Nature (London) 294:261.PubMedCrossRefGoogle Scholar
  7. Gery, I., and Waksman, B. H., 1972, J. Exp. Med. 136:143.PubMedCrossRefGoogle Scholar
  8. Gery, I., Gershon, R. K., and Waksman, B. H., 1972, J. Exp. Med. 136:128.PubMedCrossRefGoogle Scholar
  9. Gills, S., and Mizel, S. B., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:1133.CrossRefGoogle Scholar
  10. Gillis, S., and Watson, J., 1980, J. Exp. Med. 152:1709.PubMedCrossRefGoogle Scholar
  11. Gillis, S., Mochizuki, D. Y., Conlon, P. J., Hefeneider, S. H., Ramthun, C. A., Gillis, A. E.,Google Scholar
  12. Frank, M. B., Henney, C. S., and Watson, J. D., 1982, Immunol. Rev. 63:167.PubMedCrossRefGoogle Scholar
  13. Hardt, C., Rollinghoff, M., Pfizenmaier, K., Mosmann, H., and Wagner, H., 1981, J. Exp. Med. 154:262.PubMedCrossRefGoogle Scholar
  14. Howard, M., Kellser, S., Chused, T., and Paul, W. E., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:5788.PubMedCrossRefGoogle Scholar
  15. Howard, M., Farrar, J., Hilfiker, M., Johnson, B., Takatsu, K., Hamaoka, T., and Paul, W. E., 1982, J. Exp. Med. 155:914.PubMedCrossRefGoogle Scholar
  16. Kampschmidt, R. F., Pullian, L. A., and Upchurch, H. F., 1980, J. Lab. Clin. Med. 95:616.PubMedGoogle Scholar
  17. Lachman, L. B., 1983, Fed. Proc. (in press).Google Scholar
  18. Lachman, L. B., Hacker, M. P., Blyden, G. T., and Andschumacher, R. E., 1977, Cell. Immunol. 34:416.PubMedCrossRefGoogle Scholar
  19. Lachman, L. B., Moore, J. O., and Metzger, R. S., 1978, Cell. Immunol. 41:199.PubMedCrossRefGoogle Scholar
  20. Larsson, E. L., 1981, J. Immunol 126:1323.PubMedGoogle Scholar
  21. Larsson, E. L., Iscove, N. N., and Coutinho, A., 1980, Nature (London) 283:664.CrossRefGoogle Scholar
  22. Leibovich, S. J., and Ross, R., 1975, Am. J. Pathol. 78:71.PubMedGoogle Scholar
  23. Lipsky, P. E., Ellner, J. J., and Rosenthal, A. S., 1976, J. Immunol. 116:868.PubMedGoogle Scholar
  24. Maizel, A. L., Mehta, S. R., and Ford, R. J., 1979, Cell Immunol. 48:383.PubMedCrossRefGoogle Scholar
  25. Maizel, A. I., Mehta, S. R., Hauft, S., Franzini, D., Lachman, L. B., and Ford, R. J., 1981a,J. Immunol. 127:1058.PubMedGoogle Scholar
  26. Maizel, A. L., Mehta, S. R., Ford, R. J., and Lachman, L. B., 1981b, J. Exp. Med. 153:470.PubMedCrossRefGoogle Scholar
  27. Maizel, A. L., Sahasrabuddhe, C., Mehta, S., Morgan, J., Lachman, L., and Ford, R. J., 1982a, Proc. Natl. Acad. Sci. U.S.A. 79:5998.PubMedCrossRefGoogle Scholar
  28. Maizel, A. L., Sahasrabuddhe, C., Mehta, S., Morgan, J., Lachman, L., and Ford, R. J., 1982b, UCLA Symp. Mol Cell. Biol. 24:197.Google Scholar
  29. Maizel, A. L., Mehta, S., Kouttab, N., Morgan, J., Ford, R., and Sahasrabuddhe, C., 1983, Fed. Proc. (in press).Google Scholar
  30. Mier, J. W., and Gallo, R. C., 1982, J. Immunol. 128:1122.PubMedGoogle Scholar
  31. Mizel, S. B., 1982, Immunol. Rev. 63:51.PubMedCrossRefGoogle Scholar
  32. Mizel, S. B., and Ben-Zvi, A., 1980, Cell Immunol. 54:382.PubMedCrossRefGoogle Scholar
  33. Morgan, D. A., Ruscetti, F. W., and Gallo, R. C., 1976, Science 193:1007.PubMedCrossRefGoogle Scholar
  34. Murphy, P. A., Simon, P. L., and Willoughby, W. F., 1980, J. Immunol. 124:2498.PubMedGoogle Scholar
  35. Oppenheim, J. J., Stadler, B. M., Siraganian, R. P., Mage, M., and Matheson, B., 1982, Fed. Proc. 41:257.PubMedGoogle Scholar
  36. Palacios, R., Ivhed, I., Sideras, P., Nelsson, K., Sugawara, I., and Fernandez, C., 1982, Eur. J. Immunol. 12:895.PubMedCrossRefGoogle Scholar
  37. Postlethwaite, A. E., Lachman, L. B., Mainardi, C. L., and Kang, A. H., 1983, J. Exp. Med. 157:801.PubMedCrossRefGoogle Scholar
  38. Robb, R. J., and Smith, K. A., 1981, Mol. Immunol. 18:1087.PubMedCrossRefGoogle Scholar
  39. Robb, R. J., Munck, A., and Smith, K. A., 1981, J. Exp. Med. 154:1455.PubMedCrossRefGoogle Scholar
  40. Rosenstreich, D. L., Farrar, J. J., and Dougherty, S., 1976, J. Immunol. 116:131.PubMedGoogle Scholar
  41. Rossenwasser, L. J., and Dinarello, C. A., 1981, Cell Immunol. 63:134.CrossRefGoogle Scholar
  42. Ruscetti, F. W., and Gallo, R. C., 1981, Blood 57:359.Google Scholar
  43. Ruscetti, F. W., Morgan, D. A., and Gallo, R. C., 1977, J. Immunol. 119:131.PubMedGoogle Scholar
  44. Schmidt, J. A., Mizel, S. B., Cohen, D., and Green, I., 1982, J. Immunol. 128:2177.PubMedGoogle Scholar
  45. Smith, K. A., Lachman, L. B., Oppenheim, J. J., and Favata, M. D., 1980, J. Exp. Med. 151:1551.PubMedCrossRefGoogle Scholar
  46. Sredni, B., Sieckmann, D. G., Kumagar, S., House, S., Green, L, Paul, W. E., 1981, J. Exp. Med. 154:1500.PubMedCrossRefGoogle Scholar
  47. Stotter, H., Rude, E., and Wagner, H., 1980, Eur. J. Immunol. 10:719.PubMedCrossRefGoogle Scholar
  48. Wagner, H., Hardt, C., Heeg, K., Rollinghoff, M., and Pfizenmaier, K., 1980, Nature (London) 284:278.PubMedCrossRefGoogle Scholar
  49. Weite, K., Wang, C. Y., Mertelsmann, R., Venuta, S., Feldmann, S. P., and Moore, M. A. S.,1982, J Exp. Med. 156:454.CrossRefGoogle Scholar
  50. Wetzel, G. D., Swain, S. L., and Dutoon, R. W., 1982, J. Exp. Med. 156:306.PubMedCrossRefGoogle Scholar
  51. Zubler, R. H., and Kanagawa, O., 1982, J. Exp. Med. 156:415.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Lawrence B. Lachman
    • 1
  • Abby L. Maizel
    • 2
  1. 1.Immunex CorporationSeattleUSA
  2. 2.Department of Pathology, Division of PathobiologyM. D. Anderson Hospital and Tumor InstituteHoustonUSA

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