The Receptor on Mast Cells and Related Cells with High Affinity for IgE

  • Henry Metzger


Mast cells, basophils, and related tumor lines have a glycoprotein on their surface membrane that binds monomeric immunoglobulin E (IgE) with exceptionally high affinity. When the cell-bound IgE reacts with a multivalent antigen the cells rapidly degranulate—a reaction that has been shown to be mediated by the membrane glycoprotein.


Detergent Extract Forward Rate Constant Multivalent Antigen Radiation Inactivation Antireceptor Antibody 
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  1. Barrantes, F. J., 1915, Biochem. Biophys. Res. Commun. 62:407–414.CrossRefGoogle Scholar
  2. Bazin, H., Querijean, P., Beckers, A., Heremans, J. F., and Dessy, F., 1974, Immunology 26: 713–723.PubMedGoogle Scholar
  3. Becker, K. E., Ishizaka, T., Metzger, H., Ishizaka, K., and Grimley, P., 1973, J. Exp. Med. 108:394–409.CrossRefGoogle Scholar
  4. Beenich, H., Ragnarsson, U., Johansson, S. G. O., Ishizaka, K., Ishizaka, T., Levy, D. A., and Lichtenstein, L. M., 1977,Inst. Arch. Allergy Appl Immunol. 53:459–468.CrossRefGoogle Scholar
  5. Bercovici, T., and Gitler, C., 1978.Biochemistry 17:1484–1489.PubMedCrossRefGoogle Scholar
  6. Brandts, J. F., and Jacobson, B. S., 1983, Surv. Synth. Pathol. Res. (in press).Google Scholar
  7. Carson, D. A., and Metzger, H., 1974, J. Immunol. 113:1271–1277.PubMedGoogle Scholar
  8. Conrad, D. H., and Froese, A., 1976, J. Immunol. 116:319–326.PubMedGoogle Scholar
  9. Conrad, D. H., and Froese, A., 1978a, J. Immunol. 120:429–437.PubMedGoogle Scholar
  10. Conrad, D. H., and Froese, A., 1978b,Immunochemistry 15:283–288.PubMedCrossRefGoogle Scholar
  11. Conrad, D. H., Berczi, I., and Froese, A., 1976, Immunochemistry 13:329–332.PubMedCrossRefGoogle Scholar
  12. Conroy, N. C., Adkinson, N. F., and Lichtenstein, L. M., 1979, Int. Arch. Allergy Appl. Immunol.60:106–109.PubMedCrossRefGoogle Scholar
  13. DeLisi, C., 1980, Q. Rev. Biophys. 13:201–231.PubMedCrossRefGoogle Scholar
  14. DeLisi, C., 1981, Mol. Immunol 18:507–511.PubMedCrossRefGoogle Scholar
  15. Dembo, M., Goldstein, B., Sobotka, A. K., and Lichtenstein, L. M., 1979, J. Immunol. 123: 1864–1872.PubMedGoogle Scholar
  16. Dorrington, K. J., and Bennich, H., 1918,Immunol. Rev. 41:3–25.CrossRefGoogle Scholar
  17. Eccleston, E., Leonard, B. J., Lowe, J. S., and Welford, H. J., 1973, Nature (London) New Biol 244:73–76.Google Scholar
  18. Ellerson, J. R., Karlson, T., and Bennich, H., 1978, in: Protides of the Biological Fluids ,Volume 25 (H. Peeters, ed.), pp. 739–742, Pergamon Press, New York.Google Scholar
  19. Fewtrell, C., and Metzger, H., 1980,J. Immunol 125:701–710.PubMedGoogle Scholar
  20. Fewtrell, C., Kessler, A., and Metzger, H., 1919, Adv. Inflamm. Res. 1:205–221.Google Scholar
  21. Fewtrell, C., Kempner, E., Poy, G., and Metzger, H., 1981, Biochemistry 20:6589–6594.PubMedCrossRefGoogle Scholar
  22. Fewtrell, C., Goetze, A., and Metzger, H., 1982, Biochemistry 21:2004–2010.PubMedCrossRefGoogle Scholar
  23. Foreman, J. C., Hallet, M. B., and Mongar, J. L., 1977, J. Physiol 271:193–214.PubMedGoogle Scholar
  24. Fritsche, R., and Spiegelberg, H. L., 1978, J. Immunol. 121:471–478.PubMedGoogle Scholar
  25. Froese, A., 1980, Crit. Rev. Immunol. 1:79–132.PubMedGoogle Scholar
  26. Froese, A., Helm, R. M., Conrad, D. H., Isersky, C., Ishizaka, T., and Kulczycki, A., Jr., 1982a L, Immunology 45:107–116.Google Scholar
  27. Froese, A., Helm, R. M., Conrad, D. H., Isersky, C., and Ishizaka, T., 1982b, Immunology 45:117–123.Google Scholar
  28. Goetze, A., Kanellopoulos, J., Rice, D., and Metzger, H., 1981,Biochemistry 20:6341–6349.PubMedCrossRefGoogle Scholar
  29. Hamburger, R. N., 1915, Science 189:389–390.CrossRefGoogle Scholar
  30. Helm, R. M., and Froese, A., 1981a, Int. Arch. Allergy Appl. Immunol. 65:81–84.PubMedCrossRefGoogle Scholar
  31. Helm, R. M., and Froese, A., 1981b, Immunology 42:629–636.PubMedGoogle Scholar
  32. Helm, R. M., Conrad, D. H., and Froese, A., 1979, Int. Arch. Allergy Appl. Immunol. 58: 90–98.PubMedCrossRefGoogle Scholar
  33. Hempstead, B. L., Parker, C. W., and Kulczycki, A., Jr., 1981a, J. Biol. Chem. 256:10717–10723.PubMedGoogle Scholar
  34. Hempstead, B. L., Kulczycki, A., Jr., and Parker, C. W., 1981b, Biochem. Biophys. Res. Commun. 98:815–822.PubMedCrossRefGoogle Scholar
  35. Hirata, F., Axelrod, J., and Crews, F. T., 1919, Proc. Natl. Acad. Sci. U.S.A. 76:4813–816.CrossRefGoogle Scholar
  36. Hjelmeland, L. M., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:6368–6370.PubMedCrossRefGoogle Scholar
  37. Holgate, S. T., Lewis, R. A., and Austen, K. F., 1980, in: Progress in Immunology ,Volume IV (M. Fougereau and J. Dausset, eds.), pp. 847–859, Academic Press, New York.Google Scholar
  38. Holowka, D., and Metzger, H., 1982, Mol. Immunol. 19:219–222.PubMedCrossRefGoogle Scholar
  39. Holowka, D., Hartman, H., Kanellopoulos, J., and Metzger, H., 1980, J. Receptor Res 1:41–68.Google Scholar
  40. Holowka, D., Gitler, C., Bercovici, T., and Metzger, H., 1981, Nature (London) 289:806–808.CrossRefGoogle Scholar
  41. Isersky, C., Taurog, J. D., Poy, G., and Metzger, H., 1978, J. Immunol. 121:549–558.PubMedGoogle Scholar
  42. Isersky, C., Rivera, J., Mims, S., and Triche, T., 1979, J. Immunol. 122:1926–1936.PubMedGoogle Scholar
  43. Isersky, C., Rivera, J., Triche, T. J., and Metzger, H., 1982a,Mol. Immunol. 19:925–941.PubMedCrossRefGoogle Scholar
  44. Isersky, C., Rivera, J., Mims, S., Segal, D. M., and Triche, T., 1982b, Fed. Proc. 41:824 (abstr. 3240).Google Scholar
  45. Ishizaka, K., and Ishizaka, T., 1968, J. Immunol. 101:68–78.PubMedGoogle Scholar
  46. Ishizaka, T., 1982, Fed. Proc. 41:17–21.PubMedGoogle Scholar
  47. Ishizaka, T., and Ishizaka, K., 1915, Ann. N. Y. Acad. Sci. 254:462–475.CrossRefGoogle Scholar
  48. Ishizaka, T., Chang, T. H., Taggart, M., and Ishizaka, K., 1977, J. Immunol. 119:1589–1596.PubMedGoogle Scholar
  49. Ishizaka, T., Foreman, J. C., Sterk, A. R., and Ishizaka, K., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:5858–5862.PubMedCrossRefGoogle Scholar
  50. Ishizaka, T., Hirata, F., Ishizaka, K., and Axelrod, J., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:1903–1906.PubMedCrossRefGoogle Scholar
  51. Kagey-Sobotka, A., Dembo, M., Goldstein, B., Metzger, H., and Lichtenstein, L. M., 1981, J. Immunol. 127:2285–2291.PubMedGoogle Scholar
  52. Kagey-Sobotka, A., MacGlashan, D. W., and Lichtenstein, L. M., 1982, Fed. Proc. 41: 12–16.PubMedGoogle Scholar
  53. Kanellopoulos, J., Rossi, G., and Metzger, H., 1979, J. Biol. Chem. 254:7691–7697.PubMedGoogle Scholar
  54. Kanellopoulos, J. M., Liu, T. Y., Poy, G., and Metzger, H., 1980, J. Biol. Chem. 255: 9060–9066.PubMedGoogle Scholar
  55. Keller, R., 1973, Gin. Exp. Immunol. 13:139–147.Google Scholar
  56. Kempner, E. S., and Schlegel, W., 1919, Anal. Biochem. 92:2–10.CrossRefGoogle Scholar
  57. Kulczycki, A., Jr., and Metzger, H., 1974, J. Exp. Med. 140:1676–1695.PubMedCrossRefGoogle Scholar
  58. Kulczycki, A., Jr., and Parker, C. W., 1979, J. Biol. Chem. 254:3187–3193.PubMedGoogle Scholar
  59. Kulczycki, A., Jr., and Vallina, V. L., 1981, Mol. Immunol. 18:723–731.PubMedCrossRefGoogle Scholar
  60. Kulczycki, A., Jr., McNearney, T. A., and Parker, C. W., 1976, J. Immunol 117:661–665.PubMedGoogle Scholar
  61. Kulczycki, A., Jr., Hempstead, B. L., Hofmann, S. L., Wood, E. W., and Parker, C. W., 1979, J. Biol. Chem. 254:3194–3200.PubMedGoogle Scholar
  62. Kumar, N., and Metzger, H., 1982, Mol. Immunol 19:1561–1567.PubMedCrossRefGoogle Scholar
  63. Lawson, D., Fewtrell, C., Gomperts, B., and Raff, M. C., 1975,J. Exp. Med. 142:391–402.PubMedCrossRefGoogle Scholar
  64. Lawson, D., Fewtrell, C., and Raff, M. C., 1978, J. Cell Biol 79:394–400.PubMedCrossRefGoogle Scholar
  65. Leach, B. S., Collawn, J. F., Jr., and Fish, W. W., 1980, Biochemistry 19:5741–5747.PubMedCrossRefGoogle Scholar
  66. Lehrer, S. B., McCants, M. L., Farris, P. N., and Bazin, H., 1981,Immunology 44:711–716.PubMedGoogle Scholar
  67. Lichtenstein, L. M., 1971, J. Immunol. 107:1122–1129.PubMedGoogle Scholar
  68. Lichtenstein, L. M., and Osler, A. G., 1964, J. Exp. Med. 120:507–530.PubMedCrossRefGoogle Scholar
  69. Liu, F. T., Bohn, J. W., Ferry, E. L., Yamamoto, H., Molinaro, C.A., Sherman, L. A., Klinman, N. R., and Katz, D. H., 1980, J. Immunol. 124:2728–2736.PubMedGoogle Scholar
  70. MacGlashan, D. W., Jr., and Lichtenstein, L. M., 1981, J. Immunol 127:2410–2414.PubMedGoogle Scholar
  71. Magro, A. M., 1974, Nature (London) 249:572–573.CrossRefGoogle Scholar
  72. Marchesi, V. T., Furthmayr, J. H., and Tomita, M., 1976,Annu. Rev. Biochem. 45:667–698.PubMedCrossRefGoogle Scholar
  73. Markwell, M. A. K., and Fox, C. F., 1978, Biochemistry 17:4807–4817.PubMedCrossRefGoogle Scholar
  74. Mendoza, G. R., and Metzger, H., 1976, Nature (London) 264:548–550.CrossRefGoogle Scholar
  75. Metzger, H., 1977, in: Receptors and Recognition ,Volume 4 (P. Cuatrecasas and M. F.Google Scholar
  76. Metzger, H., 1978, Immunol. Rev. 41:186–199.PubMedCrossRefGoogle Scholar
  77. Metzger, H., and Bach, M., 1978, in: Immediate Hypersensitivity (M. Bach, ed.), pp. 561– 588, Marcel Dekker, New York.Google Scholar
  78. Metzger, H., and Ishizaka, T., (Chrmn.), 1982, Fed. Proc. 41:7–34.Google Scholar
  79. Metzger, H., Budman, D., and Lucky, P., 1976 ,Immunochemistry 13:417–423.PubMedCrossRefGoogle Scholar
  80. Metzger, H., Goetze, A., Kanellopoulos, J., Holowka, D., and Fewtrell, C., 1982, Fed. Proc.41:8–11.PubMedGoogle Scholar
  81. Newman, S. A., Rossi, G., and Metzger, H., 1977, Proc. Natl Acad. Sci. U.S.A. 74:869–872.PubMedCrossRefGoogle Scholar
  82. Osier, A. G., Lichtenstein, L. M., and Levy, D. A., 1968, Adv. Immunol. 8:183–231.CrossRefGoogle Scholar
  83. Pecoud, A., and Conrad, D., 1981, J. Immunol. 127:2208–2214.PubMedGoogle Scholar
  84. Pecoud, A. R., Ruddy, S., and Conrad, D. H., 1981,J. Immunol 126:1624–1629.PubMedGoogle Scholar
  85. Perez-Montfort, R., and Metzger, H., 1982, Mol. Immunol. 19:1113–1125.PubMedCrossRefGoogle Scholar
  86. Rivnay, B., and Metzger, H., 1982, J. Biol. Chem. 257:12800–12808.PubMedGoogle Scholar
  87. Rivnay, B., Wank, S. A., Poy, G., and Metzger, H., 1982, Biochemistry 21:6922–6927.PubMedCrossRefGoogle Scholar
  88. Rossi, G., Newman, S. A., and Metzger, H., 1977, J. Biol Chem. 252:704–711.PubMedGoogle Scholar
  89. Roth, P. A., and Froese, A., 1982, Immunol. Lett. 4:159–165.PubMedCrossRefGoogle Scholar
  90. Schlessinger, J., Webb, W. W., Elson, E. L., and Metzger, H., 1976, Nature (London) 264: 550–552.CrossRefGoogle Scholar
  91. Segal, D. M., Taurog, J. D., and Metzger, H., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:2993–2997.PubMedCrossRefGoogle Scholar
  92. Segal, D. M., Dower, S. K., and Titus, J. A., 1983a, J. Immunol. 130:130–137.PubMedGoogle Scholar
  93. Segal, D. M., Titus, J. A., and Dower, S. K., 1983b,J. Immunol. 130:138–144.PubMedGoogle Scholar
  94. Siraganian, R. P., and Kimberley, A. H., 1979, .J Immunol 122:1719–1725.PubMedGoogle Scholar
  95. Siraganian, R. P., Hook, W. A., and Levine, B. B., 1915, Immunochemistry 12:149–157.CrossRefGoogle Scholar
  96. Siraganian, R. P., McGivney, A., Barsumian, E. L., Crews, F. T., Hirata, F., and Axelrod, J.,1982, Fed. Proc. 41:30–34.PubMedGoogle Scholar
  97. Sobotka, A. K., Dembo, M., Goldstein, B., and Lichtenstein, L. M., 1979, J. Immunol 122:511–517.PubMedGoogle Scholar
  98. Sterk, A. R., and Ishizaka, T., 1982, J. Immunol. 128:838–843.PubMedGoogle Scholar
  99. Sullivan, A. L., Grimley, P. M., and Metzger, H., 1971, J. Exp. Med. 134:1403–1416.PubMedCrossRefGoogle Scholar
  100. Wank, S. A., DeLisi, C., and Metzger, H., 1983, Biochemistry 22:954–959.PubMedCrossRefGoogle Scholar
  101. Weis, R. M., Balakarishnan, K., Smith, B. A., and McConnell, H. M., 1982, J. Biol. Chem. 257:6440–6445.PubMedGoogle Scholar
  102. Winslow,C. M., and Austen, K. F., 1982, Fed. Proc. 41:22–29.PubMedGoogle Scholar
  103. Winslow,C. M., Lewis, R. A., and Austen, K. F., 1981,J. Exp. Med. 154:1125–1133.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Henry Metzger
    • 1
  1. 1.Section on Chemical Immunology, Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, Digestive and Kidney DiseasesNational Institutes of HealthBethesdaUSA

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