Structure of Class I Major Histocompatibility Antigens

  • Edward S. Kimball
  • John E. Coligan


H-2 antigens were discovered by Gorer (1936) as a blood group system associated with histocompatibility between mouse strains. Later research indicated that H-2 antigens were encoded by a series of genes, hence the designation H-2 complex (J. Klein, 1975). Similar complexes have been identified in all vertebrates examined (Götze, 1977) and are generally known as major histocompatibility complexes (MHC). It is now known that genes within the MHC influence as many as 60 separate traits (J. Klein, 1975, 1979) with many controlling important immunological functions.


Gene Conversion Associative Recognition Amino Acid Sequence Data Major Histocompatibility Antigen Mutant Molecule 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Edward S. Kimball
    • 1
  • John E. Coligan
    • 2
  1. 1.Frederick Cancer Research Facility, Biological Development Branch, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer InstituteNational Institutes of HealthFrederickUSA
  2. 2.Laboratory of Immunogenetics, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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