Neuropsychiatric Problems in the Elderly

  • Gabe J. Maletta


The fact that persons 65 years and older (the “elderly”) comprise the most rapidly growing portion of the U.S. population is now well known. The number has increased steadily in the twentieth century, and is now approximately 24 million (11% of the population); and by 2035, 20% of the population of the U.S. has been estimated to be over 65, or approximately 56 million people.1


Elderly Patient Neurofibrillary Tangle Senile Dementia Organic Brain Syndrome Organic Mental Disorder 


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  1. 1.
    U.S. Bureau of the Census, Projections of the population of the U.S.: 1977–2050, in Current Populations Reports, Series P-25, No. 704, Government Printing Office, Washington.Google Scholar
  2. 2.
    Raskind, M. and Eisdorfer, C., 1978, Geriatric psychopharmacology, in: Drug Treatment of Mental Disorders, (L. Simpson, ed.), Raven Press, New York.Google Scholar
  3. 3.
    Kramer, M., Tauber, C., and Redick, W., 1973, Patterns of use of psychiatric facilities by the aged: Past, present and future, in: The Psychology of Adult Development and Aging, (C. Eisdorfer and M. Lawton, eds.), American Psychiatric Association, Washington.Google Scholar
  4. 4.
    Lowenthal, M. and Berkman, P., 1967, Aging and Mental Disorder in San Francisco, Jossey-Bass, San Francisco.Google Scholar
  5. 5.
    Busse, E. and Pfeiffer, E., 1969, Functional psychiatric disorders in old age, in: Behavior and Adaptation in Late Life (E. Busse and E. Pfeiffer, eds.), Little, Brown, Boston.Google Scholar
  6. 6.
    Stotsky, B., 1967, Allegedly nonpsychiatric patients in nursing homes, J. Amer. Ger-iatr. Soc. 15:535–544.Google Scholar
  7. 7.
    Exton-Smith, A., 1978, Neurological and mental disturbances in the elderly, Age Ageing Suppl:1–3.Google Scholar
  8. 8.
    Wang, H., 1977, Dementia of old age, in: Aging and Dementia (W. Smith and M. Kinsbourne, eds.), Spectrum, New York.Google Scholar
  9. 9.
    Engel, G., 1980, The clinical application of the biopsychosocial model, Am. J. Psychiatry 137:535–544.PubMedGoogle Scholar
  10. 10.
    Brody, H., 1980, Neuroanatomy and neuropathology of aging, in: Handbook of Geriatric Psychiatry (E. Busse and D. Blazer, eds.) Van Nostrand-Reinhold, New York.Google Scholar
  11. 11.
    Terry, R., 1978, Physical changes of the aging brain, in: The Biology of Aging (J. Behnke, C. Finch, and G. Moment, eds.), Plenum, New York.Google Scholar
  12. 12.
    Maletta, G., Use of antipsychotic medication in the elderly, in: Annual Review of Gerontology and Geriatrics (C. Eisdorfer, ed.), Springer, New York, in press.Google Scholar
  13. 13.
    Seltzer, B. and Sherwin, I., 1978, Organic brain syndromes: An empirical study and critical review, Am. J. Psychiatry 135:13–21.PubMedGoogle Scholar
  14. 14.
    Raskin, A. and Rae, D., 1981, Psychiatric symptoms in the elderly, Psychopharma-col. Bull. 17:96–99.Google Scholar
  15. 15.
    Pfeiffer, E., 1979, Handling the distressed older patient, Geriatrics 34:24–29.PubMedGoogle Scholar
  16. 16.
    American Psychiatric Association, Diagnostic and statistical manual of mental disorders, 3rd ed., Washington, D.C., 1980.Google Scholar
  17. 17.
    Diagnostic and Statistical Manual of Mental Disorders, 3rd ed., 1980, American Psychiatric Association, Washington, D.C.Google Scholar
  18. 18.
    Carstensen, L. and Fremouw, W., 1981, The demonstration of a behavioral intervention for late life paranoia, Gerontologist 21:329–333.PubMedCrossRefGoogle Scholar
  19. 19.
    Manschreck, T. and Petri, M., 1978, The paranoid syndrome, Lancet ii:251–253.CrossRefGoogle Scholar
  20. 20.
    Eisdorfer, C., 1980, Paranoia and schizophrenic disorders in later life, in: Handbook of Geriatrie Psychiatry (E. Busse and D. Blazer, eds.), Van Nostrand-Reinhold, New York.Google Scholar
  21. 21.
    Murphy, E. and Brown, G., 1980, Life events, psychiatric disturbance and physical illness, Br. J. Psychiatry 136:326–338.PubMedCrossRefGoogle Scholar
  22. 22.
    Shulman, K. and Post, F., 1980, Bipolar affective disorder in old age, Br. J. Psychiatry 136:26–32.PubMedCrossRefGoogle Scholar
  23. 23.
    Loranger, A. and Levine, P., 1978, Age at onset of bipolar affective illness, Arch. Gen. Psychiatry 35:1345–1348.PubMedCrossRefGoogle Scholar
  24. 24.
    Solomon, K., 1981, The depressed patient: Social antecedents of Psychopathologie changes in the elderly, J. Am. Geriatr. Soc. 29:14–18.PubMedGoogle Scholar
  25. 25.
    Gottfries, C., 1981, Treatment of depression in the elderly. General clinical considerations, Acta Psychiatr. Scand. 63:401–409.CrossRefGoogle Scholar
  26. 26.
    Salzberger, G., 1981, Anxiety and disturbed behavior in the elderly. Am. Fam. Physician 23:151–153.PubMedGoogle Scholar
  27. 27.
    Ilfeld, F., 1980, Age, stressors, and psychosomatic disorders, Psychosomatics 21:56 – 64.PubMedGoogle Scholar
  28. 28.
    Turner, R. and Sternberg, M., 1978, Psychosocial factors in elderly patients admitted to a psychiatric hospital, Age Ageing 7:171–177.PubMedCrossRefGoogle Scholar
  29. 29.
    Bahr, H. and Cuplow, T., 1973, Old Men Drunk and Sober, NYU Press, New York.Google Scholar
  30. 30.
    Schuckit, M. and Pastor, P., 1979, Alcohol-related psychopathology in the aged, in: Psychopathology of Aging, (O. Kaplan, ed.) Academic Press, New York.Google Scholar
  31. 31.
    Rosin, A. and Glatt, M., 1971, Alcohol excess in the elderly, Quart. J. Studies on Alcoholism 32:53–59.Google Scholar
  32. 32.
    Maletta, G., Alcoholism in the aged, in: American Handbook of Alcoholism (E. Pattison and E. Kaufman, eds.), Gardner, New York, 1982.Google Scholar
  33. 33.
    Krai, V., 1978, Benign senescent forgetfulness, in: Alzheimer’s Disease: Senile Dementia and Related Disorders (R. Katzman, R. Terry, and K. Bick, eds.), Raven Press, New York.Google Scholar
  34. 34.
    The Aging Veteran: Present and Future Medical Needs, Veterans Administration, Washington, D.C., 1977.Google Scholar
  35. 35.
    Blessed, G., Tomlinson, B., and Roth, M., 1968, The association between quantitative measure of dementia and of senile change in the cerebral grey matter of elderly subjects, Bri. J. Psychiatry 114:797–811.CrossRefGoogle Scholar
  36. 36.
    Kay, D., 1972, Epidemiological aspects of organic brain disease in the aged, in: Aging and the Brain (C. Gaitz, ed.), Plenum Press, New York.Google Scholar
  37. 37.
    Hachinski, J., 1978, Cerebral blood flow differentiation of Alzheimer’s Disease from multi-infarct dementia, in: Alzheimer’s Disease: Senile Dementia and Related Disorders (R. Katzman, R. Terry, and K. Bick, eds.), Raven Press, New York.Google Scholar
  38. 38.
    Kiloh, L., 1961, Pseudo-dementia, Acta Psychiatr. Scand. 37:336–351.PubMedCrossRefGoogle Scholar
  39. 39.
    Wells, C., 1979, Pseudodementia, Am. J. Psychiatry 136:895–900.PubMedGoogle Scholar
  40. 40.
    Caine, E., 1981, Pseudodementia: Current concepts and future directions, Arch. Gen. Psychiatry, 38:1359–1364.PubMedCrossRefGoogle Scholar
  41. 41.
    Maletta, G., Pirozzolo, F. J., Thompson, G., and Mortimer, J., 1982, Organic mental disorders in a geriatric outpatient population, Am. J. Psychiatry 139:521–523.PubMedGoogle Scholar
  42. 42.
    Jenkyn, L., Walsh, D., Culver, C., and Reeves, A., 1977, Clinical signs in diffuse cerebral dysfunction, J. Neurol. Neurosurg. and Psychiatry 40:956–966.CrossRefGoogle Scholar
  43. 43.
    Folstein, M., Folstein, S., and McHugh, P., 1975, Mini-mental state: A practical method for grading the cognitive state of patients for the clinician, J. Psychiatr. Res. 12:189–198.PubMedCrossRefGoogle Scholar
  44. 44.
    Terry, R. and Davies, P., 1980, Dementia of the Alzheimers type, Ann. Rev. Neu-rosci. 3:77–95.CrossRefGoogle Scholar
  45. 45.
    Gruenberg, E., 1978, Epidemiology of senile dementia, Adv. Neurol. 19:437–457.PubMedGoogle Scholar
  46. 46.
    Gruenberg, E., 1978, Epidemiology of senile dementia, in: Neurological Epidemiology: Principles and Clinical Applications (B. Schoenberg, ed.), Raven Press, New York.Google Scholar
  47. 47.
    Katzman, R., Terry, R., and Bick, K. (eds)., 1978, Alzheimer’s Disease: Senile Dementia and Related Disorders, Raven Press, New York.Google Scholar
  48. 48.
    Cohen, D., Eisdorfer, C., and Levereng, J., 1982, Relationship of age of parents with increased incidence of Alzheimer’s disease in children. J. Amer. Geriatr. Soc. 30:656–659.Google Scholar
  49. 49.
    Pratt, R., 1970, The genetics of Alzheimer’s disease, in: Alzheimer’s Disease and Related Conditions (G. Wolstenholme and M. O’Connor, eds.), Churchill Press, London.Google Scholar
  50. 50.
    Larsson, T., Sjögren, T., and Jacobson, G. Senile dementia: A clinical, socio-medical, and genetic study. Acta Psychiatr. Scand. 39(Suppl. 167): 1–259, 1963.CrossRefGoogle Scholar
  51. 51.
    Heston, L., Mastri, A., Anderson, V., and White, J., 1981, Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions, Arch. Gen. Psychiatry, 38:1085–1090.PubMedCrossRefGoogle Scholar
  52. 52.
    Theodorescu, R., 1980, Chromosome changes in women with senile dementia, Neurol. Psychiatr. 18:195–199.Google Scholar
  53. 53.
    Ellis, W., McCulloch, J., and Corley, C., 1974, Presenile dementia in Down’s syndrome: Ultrastructural identity with Alzheimer’s disease, Neurology 24:101–106.PubMedGoogle Scholar
  54. 54.
    Heston, L., 1979, Alzheimer’s disease and senile dementia: Genetic relationships to Down’s syndrome and hematologic cancer, in: Congenital and Acquired Cognitive Disorders (R. Katzman, ed.), Raven Press, New York.Google Scholar
  55. 55.
    Davies, P., 1978, Loss of choline acetyltransferase activity in normal aging and in senile dementia, Adv. Exp. Med. Biol. 113:251–256.PubMedGoogle Scholar
  56. 56.
    Perry, E., Perry, R., Blessed, G., and Tomlinson, B., 1978, Changes in brain cholin-esterases in senile dementia of Alzheimer type, Neuropathol. Appl. Neurobiol. 4:273–277.PubMedCrossRefGoogle Scholar
  57. 57.
    Perry, E., Gibson, P., Blessed, G., Perry, R., and Tomlinson, B., 1977, Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue, J. Neurol. Sci. 34:247–265.PubMedCrossRefGoogle Scholar
  58. 58.
    Bowen, D. and Davison, A., 1980, Biochemical changes in the cholinergic system of the aging brain and in senile dementia, Psychol. Med. 10:315–319.PubMedCrossRefGoogle Scholar
  59. 59.
    Crapper, D., Karlik, S., and DeBoni, U., 1978, Aluminum and other metals in senile (Alzheimer) dementia, in: Alzheimer’s Disease: Senile Dementia and Related Disorders, (R. Katzman, R. Terry, and K. Bick, eds.), Raven Press, New York.Google Scholar
  60. 60.
    Shore, D., Millson, M., Holtz, J., Kins, S., Bridge, T., and Wyatt, R., 1980, Serum aluminum in primary degenerative dementia, Biol. Psychiatry 15:971–977.PubMedGoogle Scholar
  61. 61.
    Masters, C., Harris, J., Gajdusek, D., Gibbs, C., Bernoulli, C., and Asher, D., 1979, Creutzfeldt-Jakob disease: Patterns of worldwide occurrence and the significance of familial and sporadic clustering, Ann. Neurol. 5:177–188.PubMedCrossRefGoogle Scholar
  62. 62.
    Gibbs, C. and Gajdusek, D., 1978, Subacute spongiform virus encephalopathies: The transmissible virus dementias, in: Alzheimer’s Disease: Senile Dementia and Related Disorders, (R. Katzman, R. Terry, and K. Bick, eds.) Raven Press, New York.Google Scholar
  63. 63.
    Masters, C., Gajdusek, D., and Gibbs, C., 1981, The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer’s disease, Brain 104:535–558.PubMedCrossRefGoogle Scholar
  64. 64.
    Kay, M., 1976, Aging and the decline of immune responsiveness, in: Basic and Clinical Immunology (H. Fudenberg, D. Stites, J. Caldwell, and J. Wells, eds.), Lange, Los Altos, California.Google Scholar
  65. 65.
    Alzheimer, A., 1907, Über eine Eigenartige Erkrankung der Hirnrinde, Allg. Z. Psychiat. 64:146–148.Google Scholar
  66. 66.
    Alzheimer, A., 1911, Über eigenartige, Krankheitsfalle des Spateran Alters, Z. Ges. Neurol. Psychiat. 4:356–385.CrossRefGoogle Scholar
  67. 67.
    Herzos, A. and Kemper, T., 1980, Amygdaloid changes in aging and dementia, Arch. Neurol. 37:625–629.CrossRefGoogle Scholar
  68. 68.
    Farmer, P., Peck, A., and Terry, R., 1976, Correlation among numbers of neuritic plaques, neurofibrillary tangles, and the severity of senile dementia, J. Neuropath. 35:367–371.CrossRefGoogle Scholar
  69. 69.
    Boller, F., Mizutani, T., Roessman, U., and Gambetti, P., 1980, Parkinson disease, dementia, and Alzheimer’s disease: Clinicopathological correlations, Ann. Neurol. 7:329–335.PubMedCrossRefGoogle Scholar
  70. 70.
    Yamaguichi, F., Meyer, J., Yamamoto, M., Sakai, F., and Shaw, T., 1980, Noninvasive regional cerebral blood flow measurements in dementia, Arch. Neurol. 37:410–418.CrossRefGoogle Scholar
  71. 71.
    Kazniak, A., Garron, D., and Fox, J., 1979, Differential effects of age and cerebral atrophy upon span of immediate recall and paired-associate learning in older patients suspected of dementia, Cortex 15:285–295.Google Scholar
  72. 72.
    Wilkinson, A. and Davies, I., 1978, The influence of age and dementia of the neurone population of the mammillary bodies, Age Aging 7:151–160.CrossRefGoogle Scholar
  73. 73.
    Mancardi, G., Perdelli, F., Rivano, C., Leonardi, A., and Bugiani, O., 1980, Thickening of the basement membrane of cortical capillaries in Alzheimer’s disease, Acta. Neuropathol. 49:79–83.PubMedCrossRefGoogle Scholar
  74. 74.
    Ball, M. and Lo, P., 1977, Granulovacuolar degeneration in the aging brain and in dementia, J. Neuropathol. Exp. Neurol. 36:474–487.PubMedCrossRefGoogle Scholar
  75. 75.
    Caine, K. and Mohs, R., 1982, Enhancement of memory processes in Alzheimer’s disease with multiple-dose intravenous physostigmine, Am. J. Psychiatry 139:1421–1424.Google Scholar
  76. 76.
    Davis, K. and Mohs, R., 1982, Enhancement of memory processes in Alzheimer’s Disease with multiple-dose intravenous physostigmines, Am. J. Psychiatry 139:1421–1424.PubMedGoogle Scholar
  77. 77.
    Bruyn, G., Bots, G., and Dom, R., 1979, Huntington’s chorea: Current neuropath-ological status, in: Advances in Neurology (T. Chase, N. Wexler, and A. Barbeau, eds.), Raven Press, New York.Google Scholar
  78. 78.
    Sjogren, T., 1935, Genetical investigations of Huntington’s chorea in a Swedish peasant population, Z. Mensche. Vereb. U. Konstit. 19:131–135.Google Scholar
  79. 79.
    Albert, M., 1981, Geriatric neuropsychology, J. Consul. Clin. Psych. 49:835–850.CrossRefGoogle Scholar
  80. 80.
    Wexler, N., 1979, Perceptual-motor, cognitive, emotional characteristics of persons at risk for Huntington’s disease, in: Advances in Neurology (T. Chase, N. Wexler, and A. Barbeau, eds.), Raven Press, New York.Google Scholar
  81. 81.
    Albert, M., Butters, N., and Brandt, J., 1981, The development of remote memory loss in patients with Huntington’s disease, J. Clin. Neuropsychol. 3:1–12.PubMedCrossRefGoogle Scholar
  82. 82.
    Schultz, D., Barthal, J., and Garrett, G., 1977, Western equine encephalitis with rapid onset of Parkinsonism, Neurology 27:1095–1096.PubMedGoogle Scholar
  83. 83.
    Miyaski, K. and Fujita, T., 1977, Parkinsonism following encephalitis of unknown etiology, J. Neuropath. Exp. Neurol. 36:1–8.CrossRefGoogle Scholar
  84. 84.
    Moore, G., 1977, Influenza and Parkinson’s disease, Pub. Health Rep. 92:70–80.Google Scholar
  85. 85.
    Tohgi, H., Tomonaga, M., and Inoue, K., 1978, Parkinsonism and dementia with acoustic neurinomas, J. Neurol. 217:271–279.PubMedCrossRefGoogle Scholar
  86. 86.
    Botez, M., Bertrand, G., and Leveille, J., 1977, Parkinsonism-dementia complex, hydrocephalus and Paget’s disease, Can. J. Neurol. Sci. 4:139–142.PubMedGoogle Scholar
  87. 87.
    Melamed, E. and Lavy, S., 1977, Parkinsonism associated with chronic inhalation of carbon tetrachloride, Lancet i:1015.CrossRefGoogle Scholar
  88. 88.
    Webster, D. and Mortimer, J., 1977, Failure of L-dopa to relieve activated rigidity in Parkinson’s disease, Adv. Exp. Med. Biol. 90:297–313.PubMedGoogle Scholar
  89. 89.
    Ikeda, K., Ikeda, S., and Yoshimura, T., 1977, Idiopathic Parkinsonism with Lewy-type inclusions in cerebral cortex, Acta. Neuropathal. 39:173–175.CrossRefGoogle Scholar
  90. 90.
    Langston, J. and Famo, L., 1978, The hypothalamus in Parkinson’s disease, Ann. Neurol. 3:129–133.PubMedCrossRefGoogle Scholar
  91. 91.
    Lieberman, A., Dziatolowski, M., Kupersmith, M., Serby, M., Goodgold, A., Korein, J., and Goldstein, M., 1979, Dementia in Parkinson disease, Ann. Neurol. 6:355–359.PubMedCrossRefGoogle Scholar
  92. 92.
    Mortimer, J. A., Pirozzolo, F. J., Hansch, E. C., and Webster, D. D., 1982, Relationship of motor symptoms to intellectual deficits in Parkinson disease, Neurology 32:133–137.PubMedGoogle Scholar
  93. 93.
    Hakim, A. and Mathieson, G., 1979, Dementia in Parkinson Disease: A neuropathology study, Neurology 29:1209–1214.PubMedGoogle Scholar
  94. 94.
    Matthews, C. and Haaland, K., 1979, The effect of symptom duration and cognitive and motor performance in Parkinsonism, Neurology 29:951–956.PubMedGoogle Scholar
  95. 95.
    Pirozzolo, F. J., Hansch, E. C., Mortimer, J. A., Webster, D. D., and Kuskowski, M. A., 1982, Dementia in Parkinson disease: A neuropsychological analysis, Brain Cogmt. 1:71–83.CrossRefGoogle Scholar


  1. Adolfsson, R., Gottfries, C., Oreland, L., Wibers, A., and Winblad, B., 1980, Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type, Life Sci. 27:1029–1034.PubMedCrossRefGoogle Scholar
  2. Anderson, J. and Hubbard, B., 1981, Age-related changes in Alzheimer’s disease, Lancet 1:1261.PubMedCrossRefGoogle Scholar
  3. Andrews, G., Tennant, C., Hewson, D., and Schonell, M., 1978, The relation of social factors to physical and psychiatric illness, Am. J. Epidemiol. 108:27–35.PubMedGoogle Scholar
  4. Ball, M. and Vis, C., 1978, Relationship of granulovacuolar degeneration in hippocampal neurones to aging and to dementia in normal-pressure hydrocephalics, J. Gerontol. 33:815–824.PubMedGoogle Scholar
  5. Ban, T., 1979, Pharmacological treatment of psychosomatic manifestations in geropsy- chiatric patients, Act. Nerv. Super. 21:116–121.Google Scholar
  6. Basavaraju, N., Silverstone, F., Libow, L., and Paraskevas, K., 1981, Primitive reflexes and perceptual sensory tests in the elderly: Their usefulness in dementia, J. Chronic Dis. 34:367–377.PubMedCrossRefGoogle Scholar
  7. Bell, M. and Ball, M. Morphometric comparison of hippocampal microvasculature in aging and demented people: Diameters and densities, Acta Neuropathol. 53:299–318.Google Scholar
  8. Branchey, M., Lee, J., Amin, R., and Simpson, G., 1978, High- and low-potency neuroleptics in elderly psychiatric patients, JAMA 239:1860–1862.PubMedCrossRefGoogle Scholar
  9. Brink, T., Janakes, C., and Martinez, N., 1981, Geriatric hypochrondriasis: Situational factors, J. Am. Geriatr. Soc. 29:37–39.PubMedGoogle Scholar
  10. Brinkman, S., Sarwar, M., Levin, H., and Morris, H., 1981, Quantitative indexes of computed tomography in dementia and normal aging, Radiology 138:89–92.PubMedGoogle Scholar
  11. Buell, S. and Coleman, P., 1979, Dendritic growth in the aged human brain and failure of growth in senile dementia, Science 206:854–856.PubMedCrossRefGoogle Scholar
  12. Buell, S. and Coleman, P., 1981, Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia, Brain Res. 214:23–41.PubMedCrossRefGoogle Scholar
  13. Busse, E. and Wang, H., 1974, The multiple factors contributing to dementia in old age, in: Normal Aging 2 (E. Palmore, ed.) Durham, Duke University Press.Google Scholar
  14. Cheah, K., Baldridge, J., and Beard, O., 1979, Geriatric evaluation unit of a medical service: Role of a geropsychiatrist, J. Gerontol. 34:41–45.PubMedGoogle Scholar
  15. Cheah, K. and Beard, O., 1980, Psychiatric findings in the population of a geriatric evaluation unit: Implications, J. Am. Geriatr. Soc. 28:153–156.PubMedGoogle Scholar
  16. Comfort, A., 1979, The myth of senility: Diagnosing nonspecific major illness in the elderly, Postgrad. Med. 65:130–142.PubMedGoogle Scholar
  17. Comfort, A., 1981, Geriatric psychiatry: Mental symptoms in old people, Ala. J. Med. Sci. 18:177–183.PubMedGoogle Scholar
  18. Corsellis, J. and Brierley, J., 1959, Observations on the pathology of insidious dementia following head injury, J. Ment. Sci. 105:714–720.PubMedGoogle Scholar
  19. Goldstein, G., 1980, Psychological dysfunction in the elderly: Discussion, Proc. Annu. Meet. Am. Psychopathol. Assoc. 69:137–144.PubMedGoogle Scholar
  20. Goodin, D., Squires, K., and Starr, A., 1978, Long latency event-related components of the auditory evoked potential in dementia, Brain 101:635–648.PubMedCrossRefGoogle Scholar
  21. Granacher, R., 1981, The neurologic examination in geriatric psychiatry, Psychosomatics 22:485–499.PubMedGoogle Scholar
  22. Hirano, A., Dembitzer, H., Kurland, L., and Zimmerman, H., 1968 The fine structure of some intraganglionic alterations: Neurofibrillary tangles, granulovacuolar bodies and “rod-like” structures as seen in Guam amyotrophic lateral sclerosis and Parkin- sonism-dementia complex, J. Neuropath. Exp. Neurol. 27:167–182.PubMedCrossRefGoogle Scholar
  23. Hubbard, B. and Anderson, J., 1981, Age, senile dementia and ventricular enlargement, J. Neurol. Neurosurg. Psychiatry 44:631–635.PubMedCrossRefGoogle Scholar
  24. Hubbard, B. and Anderson, J., 1981, A quantitative study of cerebral atrophy in old age and senile dementia, J. Neurol. Sci. 50; 135–145.PubMedCrossRefGoogle Scholar
  25. Hughes, C. and Gado, M., Computed tomography and aging of the brain, Radiology 139:391–396.Google Scholar
  26. Jacoby, R. and Levy, R., 1980, Computed tomography in the elderly. 2. Senile dementia: Diagnosis and functional impairment, Br. J. Psychiatry 136:256–269.PubMedCrossRefGoogle Scholar
  27. Jarvik, L., Ruth, V., and Matsuyama, S., 1980, Organic brain syndrome and aging: A six-year follow-up of surviving twins, Arch. Gen. Psychiatry 37:280–286.PubMedCrossRefGoogle Scholar
  28. Kaszniak, A., Garron, D., Fox, J., Bergen, D., and Huckman, M., 1979, Cerebral atrophy, EEG slowing, age, education, and cognitive functioning in suspected dementia, Neurology 29:1273–1279.PubMedGoogle Scholar
  29. Katzman, R., 1976, The prevalence and malignancy of Alzheimer disease, Arch. Neurol. 33:217–222.PubMedCrossRefGoogle Scholar
  30. Katzman, R., 1981, Early detection of senile dementia, Hosp. Pract. 16:61–76.Google Scholar
  31. Krai, V., 1980, Psychosocial problems of the aged: A shared medical responsibility, J. Am. Geriatr. Soc. 28:68–70.Google Scholar
  32. Liston, E., 1979, Clinical findings in presenile dementia: A report of 50 cases, J. Nerv. Ment. Du. 167:337–342.CrossRefGoogle Scholar
  33. Mann, D. and Sinclair, K., 1978, The quantitative assessment of lipofuscin pigment, cytoplasmic RNA and nucleolar volume in senile dementia, Neuropathol. Appl. Neurobiol. 4:129–135.PubMedCrossRefGoogle Scholar
  34. McConnachie, R., 1978, The clinical assessment of brain failure in the elderly, Pharmacology 16:27–35.PubMedCrossRefGoogle Scholar
  35. McMordie, W. and Blom, S., 1979, Life review therapy: Psychotherapy for the elderly, Perspect. Psychiatr. Care 17:162–166.PubMedCrossRefGoogle Scholar
  36. Murkofsky, C., Conte, H., Plutchik, R., and Karasu, T., 1978, Clinical utility of a rapid diagnostic test series for elderly psychiatric outpatients, J. Am. Geriatr. Soc. 26:22–26.PubMedGoogle Scholar
  37. Paulson, G., 1977, The neurological examination in dementia, in: Dementia (C. Wells, ed.), Philadelphia, F. A. Davis.Google Scholar
  38. Peck, A., Wolloch, L., and Rodstein, M., 1978, Mortality of the aged with chronic brain syndrome: Further observations in a five-year study, J. Am. Geriatr. Soc. 26:170–176.PubMedGoogle Scholar
  39. Perry, E., 1980, The cholinergic system in old age and Alzheimer’s disease, Age Aging 9:1–8.CrossRefGoogle Scholar
  40. Perry, R., Blessed, G., Perry, E., and Tomlinson, B., 1980, Histochemical observations on Cholinesterase activities in the brains of elderly normal and demented (Alzheimer-type) patients, Age Aging 9:9–16.CrossRefGoogle Scholar
  41. Pfeiffer, E., 1979, Psychiatric problems in elderly patients, Geriatrics 34:23.PubMedGoogle Scholar
  42. Pfeffer, R., Kurosaki, T., Harrah, C., Chance, J., Bates, D., Detels, R., Filos, S., and Butzke, C., 1981, A survey diagnostic tool for senile dementia. Am. J. Epidemiol. 114:515–527.PubMedGoogle Scholar
  43. Phillips, M., 1979, Theoretical aspects of psychometric testing in the elderly, Age Aging 8:294–298.CrossRefGoogle Scholar
  44. Reisberg, B., Ferris, S., and Gershon, S., 1980, Pharmacotherapy of senile dementia, Proc. Annu. Meet. Am. Psychopathol. Assoc. 69:233–264.PubMedGoogle Scholar
  45. Schneck, M., Reisberg, B., and Ferris, S., 1982, An overview of current concepts of Alzheimer’s disease, Am. J. Psychiatry 139:165–173.PubMedGoogle Scholar
  46. Schuckit, M., Miller, P., and Berman, J., 1980, The three year course of psychiatric problems in a geriatric population, J. Clin. Psychiatry 41:27–32.PubMedGoogle Scholar
  47. Shraberg, D., 1980, An overview of neuropsychiatrie disturbances in the elderly, J. Am. Geriatr. Soc. 28:422–425.PubMedGoogle Scholar
  48. Spar, J., Ford, C., and Liston, E., 1979, Bipolar affective disorder in aged patients, J. Clin. Psychiatry 40:504–507.PubMedGoogle Scholar
  49. Stoudemire, A. and Thompson, T., 1981, Recognizing and treating dementia. Geriatrics 36:112–120.PubMedGoogle Scholar
  50. Sylph, J., Ross, H. and Kedward, H., 1977, Social disability in chronic psychiatric patients, Am. J. Psychiatry. 134:1391–1394.PubMedGoogle Scholar
  51. Task force sponsored by the National Institute of Aging, 1980, Senility reconsidered: Treatment possibilities for mental impairment in the elderly, JAMA 244:259–263.CrossRefGoogle Scholar
  52. Tomlinson, B., The pathology of dementia, 1977, in: Dementia (C. Wells, ed.), Philadelphia, Davis.Google Scholar
  53. Uemura, E. and Hartmann, H., 1978, RNA content and volume of nerve cell bodies in human brain. I. Prefrontal cortex in aging normal and demented patients, J. Neuropathol. Exp. Neurol. 37:487–496.PubMedCrossRefGoogle Scholar
  54. Vitaliano, P., Peck, A., Johnson, D., Prinz, P., and Eisdorfer, C., 1981 Dementia and other competing risks for mortality in the institutionalized aged, J. Am. Geriatr. Soc. 29:513–519.PubMedGoogle Scholar
  55. Walker, J. Helping elderly patients deal with emotional problems. Geriatrics 36:137–138, 1981.PubMedGoogle Scholar
  56. Wang, H., 1977, Dementia in old age, Contemp. Neurol. Ser. 15:15–26.PubMedGoogle Scholar
  57. Wells, C. and Buchanan, D., 1977, The clinical use of psychological testing in evaluation for dementia, in: Dementia (C. Wells, ed.), Philadelphia, F. A. Davis.Google Scholar
  58. White, P., Hiley, C., Goodhardt, M., Carrasco, L., Keet, J., Williams, I. and Bowen, D., 1977, Neocortical cholinergic neurons in elderly people, Lancet 1:688–671.Google Scholar
  59. Wilson, W., Musella, L., and Short, M., 1977, The electroencephalogram in dementia. Contemp. Neurol. Ser. 15:205–221.PubMedGoogle Scholar
  60. Wisniewski, K., Howe, J., Williams, D., and Wisniewski, H., 1978, Precocious aging and dementia in patients with Down’s syndrome, Biol. Psychiatry 13:619–627.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Gabe J. Maletta
    • 1
  1. 1.Geriatric Research, Education, and Clinical CenterMinneapolis Veterans Administration Medical CenterMinneapolisUSA

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