Neoplasia and Mononuclear Phagocyte Function

  • George J. Cianciolo
  • Ralph Snyderman


While the concept of immune surveillance has come under attack during the last decade (Prehn and Lappe, 1971; Prehn, 1972; Stutman, 1975; Prehn, 1976; Möller and Möller, 1976, 1978), there is substantial evidence that macrophages may play an important role in host defense against neoplasia (Alexander, 1976; Hopper and Pimm, 1976; Adams and Snyderman, 1979; Nathan et al., 1980). Macrophages are capable of infiltrating tumors and killing tumor cells in vitro and in vivo. Moreover, suppression of macrophage function can enhance tumor growth. Interestingly, there is substantial evidence that virulent tumors can enhance their ability to escape immunologically mediated destruction by releasing factors that affect mononuclear phagocyte function. At least some of the factors associated with tumors that alter macrophage function appear to be antigenically related to viral structural proteins.


Peritoneal Macrophage Chemotactic Activity Macrophage Function Macrophage Accumulation Lewis Lung Carcinoma Cell 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • George J. Cianciolo
    • 1
  • Ralph Snyderman
    • 1
  1. 1.Laboratory of Immune Effector Function, Howard Hughes Medical Institute, Division of Rheumatic and Genetic Diseases, Department of MedicineDuke University Medical CenterDurhamUSA

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