Neoplasia and Mononuclear Phagocyte Function
While the concept of immune surveillance has come under attack during the last decade (Prehn and Lappe, 1971; Prehn, 1972; Stutman, 1975; Prehn, 1976; Möller and Möller, 1976, 1978), there is substantial evidence that macrophages may play an important role in host defense against neoplasia (Alexander, 1976; Hopper and Pimm, 1976; Adams and Snyderman, 1979; Nathan et al., 1980). Macrophages are capable of infiltrating tumors and killing tumor cells in vitro and in vivo. Moreover, suppression of macrophage function can enhance tumor growth. Interestingly, there is substantial evidence that virulent tumors can enhance their ability to escape immunologically mediated destruction by releasing factors that affect mononuclear phagocyte function. At least some of the factors associated with tumors that alter macrophage function appear to be antigenically related to viral structural proteins.
KeywordsPeritoneal Macrophage Chemotactic Activity Macrophage Function Macrophage Accumulation Lewis Lung Carcinoma Cell
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