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Activities of Macrophages Within and Peripheral to the Tumor Mass

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Book cover The Reticuloendothelial System

Abstract

The reaction of the host to the presence of a growing neoplasm is extremely complex, and it seems unlikely that any single discipline will discover why a tumor grows and progresses or why some tumors invoke different reactions than others. Both cellular and humoral reactions can be detected in many instances but how these influence the behavior of the progressing neoplasm, either individually or collectively, is still far from clear. This review, by virtue of the subject matter, is narrow in terms of understanding the immunobiology of cancer, but it is hoped that by understanding how defined systems are involved one may be able to piece together the various known facts to form a more understandable picture.

This work was supported by PHS Grants CA27523 and POI-CA27589 awarded by the National Cancer Institute, DHHS.

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References

  • Becker, S., and Haskill, S., 1980, Non-T-cell-mediated cytotoxicity in MSV tumor-bearing mice. III. Macrophage-mediated cytotoxicity against autochthonous MSV tumor-isolated target cells, Int. J. Cancer 25:535.

    Article  PubMed  CAS  Google Scholar 

  • Berendt, M. J., North, R. J., and Kirstein, D. P., 1978a, The immunological basis of endotoxin-induced tumor regression: Requirement for T cell-mediated immunity, J. Exp. Med. 148:1550.

    Article  PubMed  CAS  Google Scholar 

  • Berendt, M. J., North, R. J., and Kirstein, D. P., 1978b, The immunological basis of endotoxin-induced tumor regression: Requirement for pre-existing state of concomitant anti-tumor immunity, J. Exp. Med. 1480:1560.

    Article  Google Scholar 

  • Birbeck, M. S. C, and Carter, R. L., 1972, Observations on the ultrastructure of two hamster lymphomas with particular reference to infiltrating macrophages, Int. J. Cancer 9:249.

    Article  PubMed  CAS  Google Scholar 

  • Brozna, J. P., and Ward, R. A., 1975, Anti leukotactic properties of tumor cells, J. Clin. Invest. 56:616.

    Article  PubMed  CAS  Google Scholar 

  • Cianciolo, G. J., Matthews, T. J., Bolognesi, D. P., and Synderman, R., 1980, Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses, J. Immunol. 124:2900.

    PubMed  CAS  Google Scholar 

  • Cline, M. J., and Golde, D. W., 1979, Cellular interactions in haematopoiesis, Nature (London) 277:177.

    Article  CAS  Google Scholar 

  • Dannenberg, A. M., And., M., Shima, K., and Tsuda, T., 1975, Macrophage turnover and activation in tuberculous granulomata, in: Mononuclear Phagocytes in Immunity, Infection and Pathology (R. Van Furth, ed.), p. 959, Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • De Lustro, F., and Haskill, J. S., 1978, In situ cytotoxic cells in a methylcholanthrene-induced tumor, J. Immunol. 121:1007.

    Google Scholar 

  • Dvorak, H. F., Dvorak, A. M., Mansean, E. J., Wiberg, L., and Churchill, W. H., 1979, Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs: Role of cellular immunity, myofibroblasts, micro vascular damage and infarction in line 1 tumor regression, J. Natl. Cancer Inst. 62:1459.

    PubMed  CAS  Google Scholar 

  • Eccles, S. A., and Alexander, P., 1974a, Sequestration of macrophages in growing tumours and its effect on the immunological capacity of the host, Br. J. Cancer 30:42.

    Article  PubMed  CAS  Google Scholar 

  • Eccles, S. A., and Alexander, P., 1974b, Macrophage content of tumor in relation to metastatic spread and host immune reaction, Nature (London) 250:667.

    Article  CAS  Google Scholar 

  • Eccles, S. A., and Alexander, P., 1975, Immunologically-mediated restraint of latent tumor metastases, Nature (London) 257:52.

    Article  CAS  Google Scholar 

  • Eccles, S. A., Bandlow, G., and Alexander, P., 1976, Monocytosis associated with the growth of transplanted syngeneic rat fibrosarcomata differing in immunogenicity, Br. J. Cancer 34:20.

    Article  PubMed  CAS  Google Scholar 

  • Evans, R., 1972, Macrophages in syngeneic animal tumors, Transplantation 14:468.

    Article  PubMed  CAS  Google Scholar 

  • Evans, R., 1973a, Macrophages and the tumour-bearing host, Br. J. Cancer 28:19.

    Google Scholar 

  • Evans, R., 1973b, Specific and non-specific activation of macrophages, in: Activation of Macrophages (W. H. Wagner and H. Hahn, eds.), Second Workshop Conferences, Hoechst, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Evans, R., 1976, Tumour macrophages in host immunity to malignancies, in: The Macrophage in Neoplasia (M. A. Fink, ed.), Academic Press, New York.

    Google Scholar 

  • Evans, R., 1977a, Effect of X-irradiation on host cell infiltration and growth of a murine fibrosarcoma, Br. J. Cancer 35:557.

    Article  PubMed  CAS  Google Scholar 

  • Evans, R., 1978, Macrophage requirement for growth of a murine fibrosarcoma, Br. J. Cancer 37:1086.

    Article  PubMed  CAS  Google Scholar 

  • Evans, R., 1979, Host cells in transplanted murine tumor and their possible relevance to tumor growth, J. Reticuloendothelial Soc. 26:427.

    CAS  Google Scholar 

  • Evans, R., 1980a, Further observations on the effect of cyclophosphamide on intratumor and peripheral leucocyte levels, Am. J. Pathol. 99:667.

    PubMed  CAS  Google Scholar 

  • Evans, R., 1980b, Macrophage accumulation in primary and transplanted tumors growing in C5-deficient BlO.Dy mice, Int. J. Cancer 26:227.

    Article  PubMed  CAS  Google Scholar 

  • Evans, R., and Alexander, P., 1976, Mechanisms of extra-cellular killing of nucleated mammalian cells by macrophages, in: Immunobiology of the Macrophage, (D. S. Nelson, ed.), pp. 536–576, Academic Press, New York.

    Google Scholar 

  • Evans, R., and Lawler, E. M., 1980, Macrophage content and immunogenicity of C57B/6J and BALB/cByJ methylcholanthrene-induced sarcomas, Int. J. Cancer 26:831.

    Article  PubMed  CAS  Google Scholar 

  • Evans, R., Madison, L. D., and Eidlen, D. M., 1980, Cyclophosphamide-induced changes in the cellular composition of a methylcholanthrene-induced tumor and their relation to bone marrow and blood leukocyte levels, Cancer Res. 40:395.

    PubMed  CAS  Google Scholar 

  • Facchinetti, T., Raz, A., and Goldman, R., 1978, A differential interaction of daunomycin, adriamycin, and n-trifluoracetyladriamycin-14-valerate with mouse peritoneal macrophages, Cancer Res. 38:3944.

    PubMed  CAS  Google Scholar 

  • Fauve, R. M., Hevin, B., Jacob, H., Gaillard, J. A., and Jacob, F., 1974, Anti-inflammatory effects of murine malignant cells, Proc. Natl. Acad. Sci. USA 71:4052.

    Article  PubMed  CAS  Google Scholar 

  • Fidler, I. J., Raz, A., Fogler, W. E., Kirsh, R., Bugelski, P., and Poste, G., Design of liposomes to improve delivery of macrophage-augmenting agents to alveolar macrophage, Cancer Res. 40:4460.

    Google Scholar 

  • Fromer, C. H., and Klintworth, G. K., 1976, An evaluation of the role of leukocytes in the patho-genesis of experimentally induced corneal vascularization, Am. J. Pathol. 82:157.

    PubMed  CAS  Google Scholar 

  • Haskill, J. S., 1981, Unit gravity sedimentation of tumor-associated macrophage, in: Manual Macrophage Methodology (Herscowitz, H. B., Holden, H. T., Bellanti, J. A., and Gaffar, A., eds.), p. 81, Marcel Dekker, Inc., New York.

    Google Scholar 

  • Haskill, J. S., and Parthenais, E., 1978, Immunological factors influencing the intra-tumor localization of ADCC effector cells, J. Immunol. 120:1813.

    PubMed  CAS  Google Scholar 

  • Haskill, J. S., Proctor, J. W., and Yamamura, Y., 1975a, Host responses within solid tumors. I. Monocytic effector cells within rat sarcomas, J. Natl. Cancer Inst. 54:387.

    PubMed  CAS  Google Scholar 

  • Haskill, J. S., Yamamura, Y., and Radov, L., 1975b, Host responses within solid tumors: Non-thymus-derived specific cytotoxic cells within a murine mammary adenocarcinoma, Int. J. Cancer 16:798.

    Article  PubMed  CAS  Google Scholar 

  • Haskill, J. S., Hayry, P., and Radov, L. A., 1978, Systemic and local immunity in allograft and cancer rejection, in: Contemporary Topics in Immunobiology, Vol. 8 (N. L. Warner and M. D. Cooper, eds.), pp. 107–170, Plenum Press, New York.

    Chapter  Google Scholar 

  • Haskill, J. S., Propst, R. H., and Hayes, M., 1980, Cell cycle specific effects of activated macrophages, Fifth International Symposium on Flow Cytometry, Rome, December 1980, Abstract.

    Google Scholar 

  • Herberman, R. B., Holden, H. T., Varesio, L., Taniyama, T., Puccetti, P., Kirchner, H., Gerson, J., White, S., Keisar, Y., and Haskill, J. S., 1979, Immunologic reactivity of lymphoid cells in tumors, in: Contemporary Topics in Immunobiology, Vol. 10 (I. P. Witz and M. G. Hanna, eds.), Plenum Press, New York.

    Google Scholar 

  • Hibberd, A. D., and Metcalf, D., 1971, Proliferation of macrophage and granulocyte precursors in response to primary and transplanted tumors, J. Med. Sci. 7:202.

    CAS  Google Scholar 

  • Hibbs, J. B., Jr., 1975, Activated macrophages as cytotoxic effector cells. I. Inhibition of specific and non-specific tumor resistance by trypan blue, Transplantation 19:77.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, M. K., Oettgen, H. F., Old, L. J., Mittler, R. S., and Hammerling, U., 1978, Induction and immunological properties of tumor necrosis factor, J. Reticuloendothelial Soc. 23:307.

    Google Scholar 

  • Holden, H. T., Haskill, J. S., Kirchner, H., and Herberman, R. B., 1976, Two functionally distinct anti-tumor effector cells isolated from primary murine sarcoma virus-induced tumors, J. Immunol. 117:440.

    PubMed  CAS  Google Scholar 

  • Ioachim, H. L., 1976, The stromal reaction of tumors: An expression of immune surveillance, J. Natl. Cancer Inst. 57:465.

    PubMed  CAS  Google Scholar 

  • Kaminski, M., Kaminska, G., Jacobisiak, M., and Brzezinski, W., 1977, Inhibition of lymphocyte-induced engiogenesis of isolated chondrocytes, Nature 268:238.

    Article  PubMed  CAS  Google Scholar 

  • Keller, R., 1976, Promotion of tumor growth in vivo by anti-macrophage agents, J. Natl. Cancer Inst. 57:1355.

    PubMed  CAS  Google Scholar 

  • Kerbel, R. S., Pross, H. F., and Elliot, E. V., 1975, Origin and partial characterization of Fc receptor-bearing cells found within experimental carcinomas and sarcomas, Int. J. Cancer 15:918.

    Article  PubMed  CAS  Google Scholar 

  • Key, M., and Haskill, J. S., 1981, Macrophage-mediated, antibody-dependent destruction of tumor cells in DBAJ2 mice: In vitro identification of an in situ mechanism, J. Natl. Cancer Inst. 66:103.

    PubMed  CAS  Google Scholar 

  • Lappat, E. J., and Cawein, M., 1964, A study of the leukemoid response to transplantable A-280 tumor in mice, Cancer Res. 24:302.

    PubMed  CAS  Google Scholar 

  • Lauder, I., Aherne, W., Stewart, J., and Sainsbury, R., 1977, Macrophage infiltration of breast tumours: A prospective study, J. Clin. Pathol. 30:563.

    Article  PubMed  CAS  Google Scholar 

  • MacCarty, W. C., and Mahle, A. E., 1921, Relation of differentiation and lymphocytic infiltration to postoperative longevity in gastric carcinoma, J. Lab. Clin. Med. 6:473.

    Google Scholar 

  • Mantovani, A., 1978, Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity, Int. J. Cancer 22:741.

    Article  PubMed  CAS  Google Scholar 

  • Meltzer, M. S., Stevenson, M. M., and Leonard, E. J., 1977, Characterization of macrophage chemo- taxins in tumor cell cultures and comparison with lymphocyte-derived chemotactic factors, Cancer Res. 37:721.

    PubMed  CAS  Google Scholar 

  • Moore, K., and Moore, M., 1977, Intratumour host cells of transplanted rat neoplasms of different immunogenicities, Int. J. Cancer 19:803.

    Article  PubMed  CAS  Google Scholar 

  • Normann, S. J., and Cornelius, J., 1978, Concomitant depression of tumor macrophage infiltration and systemic inflammation by progressive cancer growth, Cancer Res. 38:3453.

    PubMed  CAS  Google Scholar 

  • Normann, S. J., Schardt, M., and Sorkin, E., 1977, Do tumors escape surveillance by depression of macrophage inflammation?, in: The Macrophage and Cancer (K. James, W. McBride, and A. Stuart, eds.), Econoprint, Edinburgh.

    Google Scholar 

  • Parthenais, E., and Haskill, J. S., 1979, Immunity to the T1699 murine mammary tumor. II. Thymic influence on the in situ inflammatory response, metastatic growth and invasiveness, J. Immunol. 123:1334.

    PubMed  CAS  Google Scholar 

  • Pike, M. C., and Snyderman, R., 1976, Depression of macrophage function by a factor produced by neoplasms: A mechanism for abrogation of immune surveillance, J. Immunol. 117:1243.

    PubMed  CAS  Google Scholar 

  • Polverini, P. J., Cotran, R. S., Gimbrone, M. A., and Unanue, E. R., 1977, Activated macrophages induce vascular proliferation, Nature (London) 209:804.

    Article  Google Scholar 

  • Prehn, R. T., 1976, Do tumors grow because of the immune response of the host?, Transplant. Rev. 28:34.

    PubMed  CAS  Google Scholar 

  • Rhodes, J., Bishop, M., and Benfield, J., 1979, Tumor surveillance: How tumors may resist mac-rophage-mediated host defense, Science 203:179.

    Article  PubMed  CAS  Google Scholar 

  • Ruco, L. P., and Meltzer, M. S., 1978, Macrophage activation for tumor cytotoxicity: Tumoricidal activity by macrophages from C3H/HeJ mice requires at least two activation stimuli, Cell. Immunol. 41:35.

    Article  PubMed  CAS  Google Scholar 

  • Russell, S. W., Doe, W. F., and Cochrane, C. G., 1976, Number of macrophages and distribution of mitotic activity in regressing and progressing Moloney sarcomas, J. Immunol. 116:164.

    Google Scholar 

  • Russell, S. W., Doe, W. F., and Mclntosh, A. T., 1977, A non-cytolytic stage of macrophage activation in Moloney sarcomas, in: The Macrophage and Cancer (K. James, B. McBride, and A. Stuart, eds.), Econoprint, Edinburgh.

    Google Scholar 

  • Salmon, S. E., and Hamburger, A. W., 1978, Immunoproliferation and cancer: A common mac-rophage-derived promoter substance, Lancet 1:1289.

    Article  PubMed  CAS  Google Scholar 

  • Smith, J. B., Mclntosh, G. H., and Morris, B., 1970, The migration of cells through chronically inflamed tissues, J. Pathol. 100:21.

    Article  PubMed  CAS  Google Scholar 

  • Snyderman, R., and Pike, M. C., 1976, An inhibitor of macrophage chemotaxis produced by neoplasms, Science 192:370.

    Article  PubMed  CAS  Google Scholar 

  • Stephens, T. C., Currie, G. A., and Peacock, J. H., 1978, Repopulation of X-irradiated Lewis lung carcinoma by malignant cells and host macrophage progenitors, Br. J. Cancer 38:573.

    Article  PubMed  CAS  Google Scholar 

  • Stoychkov, N. J., Schultz, R. M., Chirigos, M. A., Pavlidas, N. A., and Goldin, A., 1979, Effects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in mice, Cancer Res. 39:3014.

    PubMed  CAS  Google Scholar 

  • Stutman, O., 1975, Delayed tumor appearance and absence of regression in nude mice infected with murine sarcoma virus, Nature (London) 253:142.

    Article  CAS  Google Scholar 

  • Tracey, D. E., and Silberman, S. L., 1980, Host-derived antibody-dependent cytotoxic cells within murine tumors, J. Natl. Cancer Inst. 64:111.

    PubMed  CAS  Google Scholar 

  • Van Loveren, H., and Den Otter, W., 1974, In vitro activation of armed macrophages and the therapeutic application in mice, J. Natl. Cancer Inst. 52:1917.

    PubMed  Google Scholar 

  • Witz, I. P., 1977, Tumor-bound immunoglobulins in situ expression of tumor immunity, Adv. Cancer Res. 25:95.

    Article  PubMed  CAS  Google Scholar 

  • Wood, G. N., and Gillespie, G. Y., 1975, Studies on the role of macrophages in regulation of growth and metastasis of murine chemically induced fibrosarcomas, Int. J. Cancer 16:1022.

    Article  PubMed  CAS  Google Scholar 

  • Wood, G. W., Morantz, R. A., Tilzer, S. A., and Gollahon, K. A., 1980, Immunoglobulin bound in vivo to Fc receptor-positive cells in human CNS tumors, J. Natl. Cancer Inst. 64:411.

    PubMed  CAS  Google Scholar 

  • Underwood, J. C, and Carr, I., 1972, The lymphoreticular infiltrate in human tumours studied by electron microscopy and tissue culture, J. Pathol. 107:v.

    Google Scholar 

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Author information

Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine, 04609, USA

    Robert Evans

  2. Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, 27514, USA

    Stephen Haskill

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  1. Robert Evans
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  2. Stephen Haskill
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman

  2. Medical College of Virginia, Richmond, Virginia, USA

    Mario Escobar

  3. Medical College of Georgia, Augusta, Georgia, USA

    Sherwood M. Reichard

  4. National Cancer Institute, National Institutes of Health, Fredrick, Maryland, USA

    Ronald B. Herberman

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© 1983 Plenum Press, New York

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Evans, R., Haskill, S. (1983). Activities of Macrophages Within and Peripheral to the Tumor Mass. In: Friedman, H., Escobar, M., Reichard, S.M., Herberman, R.B. (eds) The Reticuloendothelial System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4508-4_4

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  • DOI: https://doi.org/10.1007/978-1-4684-4508-4_4

  • Publisher Name: Springer, Boston, MA

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