Control of Tumors by the RES

  • Kurt Stern


Attempts to deal with the problem of cancer are, in addition to its basic complexity, encumbered by pseudoconflicts diverting the attention of the investigator from more essential tasks. Among them is the question as to whether cancer is a local or systemic disease. Clinical and experimental evidence prove beyond any doubt that neoplasia starts, with rare exceptions, at particular sites that can be frequently identified with exposure to a known carcinogenic agent. Depending on cellular composition, physiologic and anatomic characteristics, various sites may be more or less resistant to specific carcinogens. By the same token, overwhelming support can be mustered for systemic factors playing a critical role in development and progression of most cancers. This conclusion is based on the wide variability in appearance of cancer in human and animal populations known to have been exposed to identical kinds and amounts of carcinogenic agents. This is strikingly illustrated by the epidemiology of occupational and environmental cancers, such as those caused by asbestos or smoking in man, and ionizing radiation in man and animals. Moreover, unpredictable differences in clinical course and response to therapy encountered in patients afflicted with seemingly analogous types and stages of cancer, demand the operation of host factors distinguishing one individual from the other. Although some host factors have been identified as genetic, hormonal, and metabolic, knowledge of their exact role and modus operandi is still fragmentary. Within the last decades, a good deal of attention has been given to immunologic capabilities and the reticuloen-dothelial system (RES) in relation to resistance to neoplasia.


Phagocytic Activity Bacillus Calmette Guerin Reticuloendothelial System Splenic Cell Sinus Histiocytosis 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Kurt Stern
    • 1
  1. 1.The Lautenberg Center for General and Tumor ImmunologyThe Hebrew University—Hadassah Medical SchoolJerusalemIsrael

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