Immunosuppressive Factors Produced by Tumors and Their Effects on the RES
The suppression of immune responses due to tumors has been the subject of intensive investigation during the past decade or so. This subject has been reviewed in detail by Kamo and Friedman (1977a) and by Stutman (1975). In those reviews, the extensive studies performed in many laboratories concerning the nature and mechanism of immunosuppressive factors and immunosuppres-sion per se have been described. The nature and mechanism of how tumors may affect immune responses, either by directly subverting competence or by inducing suppressive factors or cells, were discussed. The present review focuses on immunosuppressive factors produced by tumors and how they alter the re-ticuloendothelial system function. Such tumor-associated or derived factors impair lymphocyte and/or macrophage activity or may generate suppressor cells that depress other immunologic functions.
KeywordsDepression Lymphoma Lactate Leukemia Sarcoma
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