Neoplasms of the Mononuclear Phagocyte System

  • Robert D. Collins
  • Betsy Bennett
  • Alan D. Glick


Malignant neoplasms of the mononuclear phagocyte system (MPS) (Van Furth et al ., 1972) include acute and chronic monocytic leukemias, and various malignant histiocytoses. There is considerable confusion in the classification of these neoplasms, particularly in regard to the malignant histiocytoses and their separation from histiocytoses of varying aggressiveness (e.g., histiocytosis X). Furthermore, the diagnosis of histiocytic neoplasms has often been based on histopathologic criteria of varying precision, and only recently have such diagnoses been confirmed by cytochemical and ultrastructural examinations. Finally, our knowledge of MPS subpopulations is rudimentary and immunologic or functional techniques for recognizing normal or neoplastic MPS subpopulations are not generally available. It is not surprising, therefore, that the clinical and pathological features of only a few MPS neoplasms are well-defined (Groopman and Golde, 1981). In this chapter, malignant neoplasms are separated from those proliferations such as histiocytosis X in which malignant features have not been clearly established. In this regard/we have not accepted fatal illnesses associated with widespread dissemination as definitive evidence for malignancy.


Hairy Cell Leukemia Eosinophilic Granuloma Monocytic Leukemia Mononuclear Phagocyte System Abundant Eosinophilic Cytoplasm 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Robert D. Collins
    • 1
  • Betsy Bennett
    • 1
  • Alan D. Glick
    • 1
  1. 1.Department of PathologyVanderbilt University School of MedicineNashvilleUSA

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