Abstract
The contraction of striated muscle is known to be caused by an active relative sliding of the thick and thin myofilaments.1,2 In addition, there is an increasing amount of evidence suggesting that active sliding between protein filaments occurs not only between the thin actin-containing filaments and the thick myosin-containing filaments, involved in the motility of a wide variety of cells,3 but also in the cilia motion involving dynein and tubulin rather than myosin and actin.4 The most widely held view for the molecular mechanism of the sliding process in striated muscle is that the cross-bridges which are projected outward from the thick myofilament moves cyclically upon activation. The cross-bridge motions in turn pull the thin myofilament. So far, this scheme has been supported only by indirect evidence.5,6
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
H. E. Huxley, Science, 164: 1356 (1969).
A. F. Huxley, J. Physiol. 243: 1 (1974).
T. D. Pollard and R. R. Weihing, C. R. Crit. Rev. Biochem. 2: 1 (1974).
K. E. Summen and I. R. Gibbons, PNAS U.S.A. 68: 3092 (1971).
H. E. Huxley and W. Brown, J. Mol. Biol. 30: 383 (1967).
J. Borjedo, S. Outman and M. F. Moral, PNAS U.S.A. 76: 6346 (1979).
B. Chu, Phys. Scripta, 19: 458 (1979).
S. H. Chen, B. Chu and R. Nossal, ed., Scattering Techniques Applied to Supramolecular and Non-equilibrium Systems, pp. 928, Plenum Press, New York (1981).
T. Maeda and S. Fujime, Macromolecules, 14: 809 (1981).
J. Neuman and F. D. Carlson, Biophys. J., 29: 37 (1980).
R. C. Harkell and F. D. Carlson, Biophys. J., 33: 39 (1981).
K. Kubota, B. Chu, S.-F. Fan, M. M. Dewey, P. Brink and D. Colflesh, submitted to J. Mol. Biol.
W. Lehman and A. G. Szent-Gyorgyi, J.gen. Physiol., 66: 1 (1975).
D. T. Koppel, J. Chem. Phys., 57: 4814 (1972).
M. M. Dewey, R. J. C. Levine, D. Colflesh, B. Walcott, L. Braun, A. Baldwin and P. Brink in Cross-Bridge Mechanism in Muscle Contraction (Sugi, H. and Pollack, G. H., ed.) 3–22, University of Tokyo Press, Tokyo (1979).
M. M. Dewey, D. Colflesh, P. Brink, S.-F. Fan, B. Gaylein and N. Gural in Basic Biology of Muscle: A Comparative Approach. (Twarog, B., Levine, R. J. C. and Dewey, M. M., ed.) Raven Press, New York (1982).
S.-F. Fan, Scientia Sinica, 13: 692 (1964).
H. E. Huxley, Cold Spring Harbor Symp. Quant. Biol., 37: 361 (1972).
S.-F. Fan and Y.-S. Wen, Acta Physiol. Sinica, 31: 227 (1979).
C. C. Goodno, PNAS U.S.A., 76: 2620 (1979).
C. C. Goodno and E. W. Taylor, ibid., 79: 21 (1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Plenum Press, New York
About this chapter
Cite this chapter
Fan, SF., Dewey, M.M., Colflesh, D., Chu, B. (1983). Further Evidence of Cross-Bridge Motions in Limulus Thick Myofilament Suspensions. In: Earnshaw, J.C., Steer, M.W. (eds) The Application of Laser Light Scattering to the Study of Biological Motion. NATO Advanced Science Institutes Series, vol 59. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4487-2_30
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4487-2_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4489-6
Online ISBN: 978-1-4684-4487-2
eBook Packages: Springer Book Archive