Advertisement

Further Evidence of Cross-Bridge Motions in Limulus Thick Myofilament Suspensions

  • S.-F. Fan
  • M. M. Dewey
  • D. Colflesh
  • B. Chu
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 59)

Abstract

The contraction of striated muscle is known to be caused by an active relative sliding of the thick and thin myofilaments.1,2 In addition, there is an increasing amount of evidence suggesting that active sliding between protein filaments occurs not only between the thin actin-containing filaments and the thick myosin-containing filaments, involved in the motility of a wide variety of cells,3 but also in the cilia motion involving dynein and tubulin rather than myosin and actin.4 The most widely held view for the molecular mechanism of the sliding process in striated muscle is that the cross-bridges which are projected outward from the thick myofilament moves cyclically upon activation. The cross-bridge motions in turn pull the thin myofilament. So far, this scheme has been supported only by indirect evidence.5,6

Keywords

High Frequency Component Relaxing Solution Short Filament Cilium Motion Delay Time Range 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    H. E. Huxley, Science, 164: 1356 (1969).ADSCrossRefGoogle Scholar
  2. 2.
    A. F. Huxley, J. Physiol. 243: 1 (1974).Google Scholar
  3. 3.
    T. D. Pollard and R. R. Weihing, C. R. Crit. Rev. Biochem. 2: 1 (1974).CrossRefGoogle Scholar
  4. 4.
    K. E. Summen and I. R. Gibbons, PNAS U.S.A. 68: 3092 (1971).ADSCrossRefGoogle Scholar
  5. 5.
    H. E. Huxley and W. Brown, J. Mol. Biol. 30: 383 (1967).CrossRefGoogle Scholar
  6. 6.
    J. Borjedo, S. Outman and M. F. Moral, PNAS U.S.A. 76: 6346 (1979).ADSCrossRefGoogle Scholar
  7. 7.
    B. Chu, Phys. Scripta, 19: 458 (1979).ADSCrossRefGoogle Scholar
  8. 8.
    S. H. Chen, B. Chu and R. Nossal, ed., Scattering Techniques Applied to Supramolecular and Non-equilibrium Systems, pp. 928, Plenum Press, New York (1981).Google Scholar
  9. 9.
    T. Maeda and S. Fujime, Macromolecules, 14: 809 (1981).ADSCrossRefGoogle Scholar
  10. 10.
    J. Neuman and F. D. Carlson, Biophys. J., 29: 37 (1980).CrossRefGoogle Scholar
  11. 11.
    R. C. Harkell and F. D. Carlson, Biophys. J., 33: 39 (1981).CrossRefGoogle Scholar
  12. 12.
    K. Kubota, B. Chu, S.-F. Fan, M. M. Dewey, P. Brink and D. Colflesh, submitted to J. Mol. Biol.Google Scholar
  13. 13.
    W. Lehman and A. G. Szent-Gyorgyi, J.gen. Physiol., 66: 1 (1975).CrossRefGoogle Scholar
  14. 14.
    D. T. Koppel, J. Chem. Phys., 57: 4814 (1972).ADSCrossRefGoogle Scholar
  15. 15.
    M. M. Dewey, R. J. C. Levine, D. Colflesh, B. Walcott, L. Braun, A. Baldwin and P. Brink in Cross-Bridge Mechanism in Muscle Contraction (Sugi, H. and Pollack, G. H., ed.) 3–22, University of Tokyo Press, Tokyo (1979).Google Scholar
  16. 16.
    M. M. Dewey, D. Colflesh, P. Brink, S.-F. Fan, B. Gaylein and N. Gural in Basic Biology of Muscle: A Comparative Approach. (Twarog, B., Levine, R. J. C. and Dewey, M. M., ed.) Raven Press, New York (1982).Google Scholar
  17. 17.
    S.-F. Fan, Scientia Sinica, 13: 692 (1964).Google Scholar
  18. 18.
    H. E. Huxley, Cold Spring Harbor Symp. Quant. Biol., 37: 361 (1972).CrossRefGoogle Scholar
  19. 19.
    S.-F. Fan and Y.-S. Wen, Acta Physiol. Sinica, 31: 227 (1979).Google Scholar
  20. 20.
    C. C. Goodno, PNAS U.S.A., 76: 2620 (1979).ADSCrossRefGoogle Scholar
  21. 21.
    C. C. Goodno and E. W. Taylor, ibid., 79: 21 (1982).ADSGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • S.-F. Fan
    • 1
  • M. M. Dewey
    • 1
  • D. Colflesh
    • 1
  • B. Chu
    • 2
  1. 1.Department of Anatomical Sciences Health Sciences CenterState University of New York at Stony BrookStony BrookUSA
  2. 2.Department of ChemistryState University of New York at Stony BrookStony BrookUSA

Personalised recommendations