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A Note on HPLC Determination of Cefotaxime and Its Metabolites

  • J. Chamberlain
  • D. Dell
  • F. G. Coppin
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 12)

Abstract

The pharmacokinetics of antibiotics are often studied by means of microbiological assays. However this is subject to some uncertainty if the drug is metabolized to species having a different spectrum of antimicrobial activity compared with the parent. For basic pharmacokinetic work therefore it is desirable to use a method which separates parent drug from active metabolites and preferably quantitates the metabolites in addition.

Keywords

Antimicrobial Activity Active Metabolite Human Urine Drug Metabolite Microbiological Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. Chamberlain
    • 1
  • D. Dell
    • 1
  • F. G. Coppin
    • 1
  1. 1.Hoechst Pharmaceuticals Research LaboratoriesMilton Keynes, Bucks.UK

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