Problems Arising from Assaying Low Concentrations by HPLC
Assays of drugs and metabolites by HPLC are frequently carried out at very high sensitivity, i.e. conditions of low signal-to-noise ratio. This brings in train a number of problems; some are well known, others are not suspected by those workers who deal only with samples at high concentration. The examples given represent problems that have occurred in a drug metabolism bioanalytical laboratory. Readers may add to the list.
KeywordsCheck Valve Baseline Drift Large Injection Volume Soda Glass Fluorescein Solution
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