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Problems Arising from Assaying Low Concentrations by HPLC

  • C. R. Jones
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 12)

Abstract

Assays of drugs and metabolites by HPLC are frequently carried out at very high sensitivity, i.e. conditions of low signal-to-noise ratio. This brings in train a number of problems; some are well known, others are not suspected by those workers who deal only with samples at high concentration. The examples given represent problems that have occurred in a drug metabolism bioanalytical laboratory. Readers may add to the list.

Keywords

Check Valve Baseline Drift Large Injection Volume Soda Glass Fluorescein Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Reid, E. (1981) in Trace-Organic Sample Handling (Vol. 10, this series; Reid, E., ed.) , Horwood, Chichester, pp. 15–31Google Scholar
  2. 2.
    Scales, B. (1981) as for 1., pp. 353–363.Google Scholar
  3. 3.
    Hooper, W.C. & Smith, M.T. (1981)J. Pharm. Sci. 70, 346–347.CrossRefGoogle Scholar
  4. 4.
    Feyerabend, C. & Russell, M.A.H. (1980)J. Pharm. Pharmacol. 32, 178–181.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • C. R. Jones
    • 1
  1. 1.Wellcome Research LaboratoriesBeckenham, KentUK

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