A Note on Determination of Atracurium and Its Metabolites
Atracurium is a neuromuscular blocking agent with the structure shown overleaf. It was designed to undergo rapid non-enzymic inactivation at physiological pH and temperature by a process of Hofmann elimination , which is advantageous because a drug which relies upon metabolism or excretion to terminate its actions may have a prolonged effect in patients with hepatic or renal insufficiency. In this elimination, a quaternary amine becomes tertiary  (Fig. 1).
KeywordsQuaternary Amine Sodium Nitrate Neuromuscular Blocking Agent Ester Hydrolysis Wellcome Research
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