A Note on Selective Column-Extraction of Psycho-Active Drugs and Metabolites

  • R. G. Muusze
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 12)


The determination of psycho-active drugs in blood commonly starts with a liquid-liquid extraction [1–3]. Selective extraction of metabolites can be done with different organic solvents at different pH values [4]. Solvent extraction from serum has two drawbacks: the yield varies considerably (40–80%), and the cleaning and preparation of glassware is time-consuming. Drug concentrates, for HPLC analysis, can alternatively be obtained by disposable RP columns from diluted serum.


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  1. 1.
    Muusze, R.G. (1980) in Phenothiazines and Structurally Related Drugs (Usdin, E., Eckert, H. & Forrest, I.S., eds.) , Elsevier, Amsterdam, pp. 125–128.Google Scholar
  2. 2.
    Miyazaki, K., Arita, T., Oka, I., Koyama, T. & Yamashita, I. (1981)J. Chromatog. 223, 449–453.CrossRefGoogle Scholar
  3. 3.
    Gillespie, T.J. & Sipes, I.G. (1981)J. Chromatog. 223, 95–102.CrossRefGoogle Scholar
  4. 4.
    Whelpton, R. & Curry, S.H. (1976)J. Pharm. Pharmacol. 28, 869–873.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. G. Muusze
    • 1
  1. 1.Sint Joris Gasthuis (Mental Hospital)DelftThe Netherlands

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