A Note on Selective Column-Extraction of Psycho-Active Drugs and Metabolites
The determination of psycho-active drugs in blood commonly starts with a liquid-liquid extraction [1–3]. Selective extraction of metabolites can be done with different organic solvents at different pH values . Solvent extraction from serum has two drawbacks: the yield varies considerably (40–80%), and the cleaning and preparation of glassware is time-consuming. Drug concentrates, for HPLC analysis, can alternatively be obtained by disposable RP columns from diluted serum.
KeywordsBackground Signal Mental Hospital Drug Metabolite Column Extraction Previous Page
- 1.Muusze, R.G. (1980) in Phenothiazines and Structurally Related Drugs (Usdin, E., Eckert, H. & Forrest, I.S., eds.) , Elsevier, Amsterdam, pp. 125–128.Google Scholar