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The Identification of Amitriptyline and Benzodiazepine Metabolites

  • Ian D. Watson
  • David R. Jarvie
  • Anne Chambers
  • Michael J. Stewart
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 12)

Abstract

HPLC peaks in an assay developed for amitriptyline and its metabolites were of unclear identity, elucidated by certain approaches. The accuracy of a semi-quantitative EMIT procedure for benzodiazepines was validated. Determining the contribution of metabolites to a drug assay poses problems to a clinically oriented laboratory, as these studies illustrate.

Keywords

Retention Volume Royal Infirmary HPLC Peak Welwyn Garden City Mass Fragmentogram 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Ian D. Watson
    • 1
  • David R. Jarvie
    • 1
    • 2
  • Anne Chambers
    • 1
  • Michael J. Stewart
    • 1
  1. 1.Department of BiochemistryRoyal InfirmaryGlasgowUK
  2. 2.Department of Clinical ChemistryRoyal InfirmaryEdinburghUK

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