Interaction of Mycobacteria with Normal and Immunologically Activated Alveolar Macrophages

  • Quentin N. Myrvik
  • Eva S. Leake
  • Klara Tenner-Racz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


It is well-established that the Mycobacteria differ in their virulence for various laboratory animals. The mechanisms by which Mycobacteria express virulence could be the result of a combination of several factors including a) some form of toxic factor elaborated by Mycobacteria, b) destruction of the phagosomal membrane allowing Mycobacteria to escape and grow in the cytoplasm of macrophages, c) inhibition of lysosome fusion and d) a deficient antimicrobial system in macrophages even in the face of normal lysosome-phagosome fusion, especially in non-immunologically activated macrophages.


Alveolar Macrophage Acridine Orange Mycobacterium Smegmatis Mycobacterium Bovis Secondary Lysosome 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Quentin N. Myrvik
    • 1
  • Eva S. Leake
    • 1
  • Klara Tenner-Racz
    • 2
  1. 1.Department of Microbiology and ImmunologyThe Bowman Gray School of Medicine of Wake Forest UniversityWinston-SalemUSA
  2. 2.Dept. of PathologyBernhard-Nocht Institut für Schiffs- und TropenkrankheitenHamburgW. Germany

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