Interaction of Mycobacteria with Normal and Immunologically Activated Alveolar Macrophages
It is well-established that the Mycobacteria differ in their virulence for various laboratory animals. The mechanisms by which Mycobacteria express virulence could be the result of a combination of several factors including a) some form of toxic factor elaborated by Mycobacteria, b) destruction of the phagosomal membrane allowing Mycobacteria to escape and grow in the cytoplasm of macrophages, c) inhibition of lysosome fusion and d) a deficient antimicrobial system in macrophages even in the face of normal lysosome-phagosome fusion, especially in non-immunologically activated macrophages.
KeywordsAlveolar Macrophage Acridine Orange Mycobacterium Smegmatis Mycobacterium Bovis Secondary Lysosome
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